Dendrimer-Based Nanomedicine (Paramagnetic Nanoparticle, Nanocombretastatin, Nanocurcumin) for Glioblastoma Multiforme Imaging and Therapy

Ali, Meser M.

doi:10.31031/nacs.2021.06.000639

Cited by 4 publications

(2 citation statements)

References 68 publications

(93 reference statements)

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“…Polymers 2023, 15, x FOR PEER REVIEW 5 of 45 magnetic targeting capabilities led to an increase in the effectiveness of photodynamic therapy, both in vitro and in vivo. The production of theragnostic nanoparticles and glioma cells was carried out by Ali et al [31] using C6 mice. In order to produce these particles, gadolinium oxide nanoparticles were first coated with either paclitaxel (PTX) or folic acid (FA)-conjugated dextran.…”

Section: Poly(2-hydroxyethyl Methacrylate)mentioning

confidence: 99%

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

Harun-Or-Rashid,

Aktar,

Hossain

et al. 2023

Polymers

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Polymeric drug delivery technology, which allows for medicinal ingredients to enter a cell more easily, has advanced considerably in recent decades. Innovative medication delivery strategies use biodegradable and bio-reducible polymers, and progress in the field has been accelerated by future possible research applications. Natural polymers utilized in polymeric drug delivery systems include arginine, chitosan, dextrin, polysaccharides, poly(glycolic acid), poly(lactic acid), and hyaluronic acid. Additionally, poly(2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide), poly(ethylenimine), dendritic polymers, biodegradable polymers, and bioabsorbable polymers as well as biomimetic and bio-related polymeric systems and drug-free macromolecular therapies have been employed in polymeric drug delivery. Different synthetic and natural biomaterials are in the clinical phase to mitigate different diseases. Drug delivery methods using natural and synthetic polymers are becoming increasingly common in the pharmaceutical industry, with biocompatible and bio-related copolymers and dendrimers having helped cure cancer as drug delivery systems. This review discusses all the above components and how, by combining synthetic and biological approaches, micro- and nano-drug delivery systems can result in revolutionary polymeric drug and gene delivery devices.

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Section: Poly(2-hydroxyethyl Methacrylate)mentioning

confidence: 99%

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

Harun-Or-Rashid,

Aktar,

Hossain

et al. 2023

Polymers

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“…Other potential applications for dendrimers will undoubtedly continue to be appreciated as the fields of nanotechnology and genetic engineering continue to advance. Imaging agents can be loaded onto dendrimers along with therapeutics to promote targeted theranostic approaches [163]. Multiple biologics and traditional chemotherapeutics can be co-conjugated to dendrimers to accomplish dual functions [164].…”

Section: Other Applicationsmentioning

confidence: 99%

Dendrimer Technology in Glioma: Functional Design and Potential Applications

Gaitsch

Hersh

Alomari

et al. 2023

Cancers

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Novel therapeutic and diagnostic methods are sorely needed for gliomas, which contribute yearly to hundreds of thousands of cancer deaths worldwide. Despite the outpouring of research efforts and funding aimed at improving clinical outcomes for patients with glioma, the prognosis for high-grade glioma, and especially glioblastoma, remains dire. One of the greatest obstacles to improving treatment efficacy and destroying cancer cells is the safe delivery of chemotherapeutic drugs and biologics to the tumor site at a high enough dose to be effective. Over the past few decades, a burst of research has leveraged nanotechnology to overcome this obstacle. There has been a renewed interest in adapting previously understudied dendrimer nanocarriers for this task. Dendrimers are small, highly modifiable, branched structures featuring binding sites for a variety of drugs and ligands. Recent studies have demonstrated the potential for dendrimers and dendrimer conjugates to effectively shuttle therapeutic cargo to the correct tumor location, permeate the tumor, and promote apoptosis of tumor cells while minimizing systemic toxicity and damage to surrounding healthy brain tissue. This review provides a primer on the properties of dendrimers; outlines the mechanisms by which they can target delivery of substances to the site of brain pathology; and delves into current trends in the application of dendrimers to drug and gene delivery, and diagnostic imaging, in glioma. Finally, future directions for translating these in vitro and in vivo findings to the clinic are discussed.

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Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting

Ibrahim,

Fathalla,

Fatease

et al. 2024

Expert Opinion on Drug Delivery

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Dendrimer-Based Nanomedicine (Paramagnetic Nanoparticle, Nanocombretastatin, Nanocurcumin) for Glioblastoma Multiforme Imaging and Therapy

Cited by 4 publications

References 68 publications

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

Dendrimer Technology in Glioma: Functional Design and Potential Applications

Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting

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