Dendrimer-based nanoparticles in cancer chemotherapy and gene therapy

Jiang, Lei; Zhou, Sensen; Zhang, Xiaoke; Wu, Wei; Jiang, Xiqun

doi:10.1007/s40843-018-9242-3

Cited by 23 publications

(10 citation statements)

References 188 publications

(178 reference statements)

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“…Polymer flexibility relies on length, compatibility with proteins for forming complex structures, and chemical nature affecting the overall architecture of the conjugate (Shu et al, 2013). Another important factor is polymer topology; for example, brush-like, hyperbranched, or dendritic topologies provide good characteristic features compared with their linear counterparts while forming polymer bioconjugates (40)(41)(42)(43). Viscosity analysis is also an explicit requirement as the anti-polyelectrolyte effect causing the change in polymer conformation tends to increase the intrinsic viscosity (44,45).…”

Section: Selection Of Polymermentioning

confidence: 99%

Nanohybrids as Protein-Polymer Conjugate Multimodal Therapeutics

Kiran

Khan

Neekhra

et al. 2021

Front. Med. Technol.

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Protein therapeutic formulations are being widely explored as multifunctional nanotherapeutics. Challenges in ensuring susceptibility and efficacy of nanoformulation still prevail owing to various interactions with biological fluids before reaching the target site. Smart polymers with the capability of masking drugs, ease of chemical modification, and multi-stimuli responsiveness can assist controlled delivery. An active moiety like therapeutic protein has started to be known as an important biological formulation with a diverse medicinal prospect. The delivery of proteins and peptides with high target specificity has however been tedious, due to their tendency to aggregate formation in different environmental conditions. Proteins due to high chemical reactivity and poor bioavailability are being researched widely in the field of nanomedicine. Clinically, multiple nano-based formulations have been explored for delivering protein with different carrier systems. A biocompatible and non-toxic polymer-based delivery system serves to tailor the polymer or drug better. Polymers not only aid delivery to the target site but are also responsible for proper stearic orientation of proteins thus protecting them from internal hindrances. Polymers have been shown to conjugate with proteins through covalent linkage rendering stability and enhancing therapeutic efficacy prominently when dealing with the systemic route. Here, we present the recent developments in polymer-protein/drug-linked systems. We aim to address questions by assessing the properties of the conjugate system and optimized delivery approaches. Since thorough characterization is the key aspect for technology to enter into the market, correlating laboratory research with commercially available formulations will also be presented in this review. By examining characteristics including morphology, surface properties, and functionalization, we will expand different hybrid applications from a biomaterial stance applied in in vivo complex biological conditions. Further, we explore understanding related to design criteria and strategies for polymer-protein smart nanomedicines with their potential prophylactic theranostic applications. Overall, we intend to highlight protein-drug delivery through multifunctional smart polymers.

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Section: Selection Of Polymermentioning

confidence: 99%

Nanohybrids as Protein-Polymer Conjugate Multimodal Therapeutics

Kiran

Khan

Neekhra

et al. 2021

Front. Med. Technol.

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“…Gene therapy based on transfection of DNA or RNA into targeted cells, has been extensively explored for cancer therapy [110]. In order to allow genes to quickly enter cells and function without being degraded, positively charged NPs are usually used as vectors to compact negatively charged genes for gene delivery to cells [111]. In principle, the transfection efficacy of high-generation PAMAM dendrimers is greater than the low-generation counter- parts, while their cytotoxicity is higher [112,113].…”

Section: Gene Deliverymentioning

confidence: 99%

Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: A concise review

Song

Shen

Rodrigues

et al. 2020

Coordination Chemistry Reviews

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“…Owing to their hydrophobic core and hydrophilic surface, dendrimers have the ability to enhance the solubility of drugs by covalent or noncovalent interaction. 21 Actually, hydrophobic drugs can be entrapped in their hydrophobic cavity, while the multivalent surface can conjugate hydrophilic drugs. 22 So far, diverse dendrimers have been designed and utilized, 23 such as poly(amidoamine) (PAMAM), 24 poly(prophylenimine), 25 and poly(L-lysine).…”

Section: ■ Introductionmentioning

confidence: 99%

Computer Simulations on a pH-Responsive Anticancer Drug Delivery System Using Zwitterion-Grafted Polyamidoamine Dendrimer Unimolecular Micelles

et al. 2021

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Unimolecular micelles have attracted wide attention in the field of drug delivery because of their thermodynamic stability and uniform size distribution. However, their drug loading/release mechanisms at the molecular level have been poorly understood. In this work, the stability and drug loading/release behaviors of unimolecular micelles formed using generation-5 polyamidoamine-graft-poly(carboxybetaine methacrylate) (PAMAM(G5)-PCBMA) were studied by dissipative particle dynamics simulations. In addition, the unimolecular micelles formed using generation-5 polyamidoamine-graft-poly(ethyleneglycol methacrylate) (PAMAM(G5)-PEGMA) were used as a comparison. The simulation results showed that PAMAM(G5)-PCBMA can spontaneously form core–shell unimolecular micelles. The PAMAM(G5) dendrimer constitutes a hydrophobic core to load the doxorubicin (DOX), while the zwitterionic PCBMA serves as a protective shell to improve the stability of the unimolecular micelle. The DOX can be encapsulated into the cavity of PAMAM(G5) at the physiological pH 7.4. The drug loading efficiency and drug loading content showed some regularities with the increase in the drug concentration. At the acidic pH 5.0, the loaded DOX can be released gradually from the hydrophobic core. The comparison of DOX-loaded morphologies between the PAMAM(G5)-PCBMA system and PAMAM(G5)-PEGMA system showed that the former has better monodisperse stability. This work could offer theoretical guidance for the design and development of promising unimolecular micelles for drug delivery.

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Dendrimer-based nanoparticles in cancer chemotherapy and gene therapy

Cited by 23 publications

References 188 publications

Nanohybrids as Protein-Polymer Conjugate Multimodal Therapeutics

Nanohybrids as Protein-Polymer Conjugate Multimodal Therapeutics

Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: A concise review

Computer Simulations on a pH-Responsive Anticancer Drug Delivery System Using Zwitterion-Grafted Polyamidoamine Dendrimer Unimolecular Micelles

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