Dendrimer-based strategies for cancer therapy: Recent advances and future perspectives

Xiong, Zhijuan; Shen, Mingwu; Shi, Xiangyang

doi:10.1007/s40843-018-9271-4

Cited by 57 publications

(32 citation statements)

References 141 publications

(217 reference statements)

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“…Dendrimers, in particular, poly(amidoamine) (PAMAM) dendrimers are a class of branched, monodispersed, and synthetic macromolecules with both internal cavity and periphery functional groups [ 17 ]. The unique structural features of dendrimers allow the entrapment of inorganic nanoparticles (NPs) within their interiors and covalent conjugation of targeting ligands, drugs and bioactive ingredients for various drug delivery and imaging purposes [ [18] , [19] , [20] , [21] , [22] , [23] ]. It is advantageous to combine dendrimers with CDs for nanomedicinal applications.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrug-resistant tumors using multifunctional dendrimer/carbon dot nanohybrids

Lin

Fan

et al. 2021

Bioactive Materials

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Development of innovative nanomedicine enabling enhanced theranostics of multidrug-resistant (MDR) tumors remains to be challenging. Herein, we report the development of a newly designed multifunctional yellow-fluorescent carbon dot (y-CD)/dendrimer nanohybrids as a platform for ultrasound (US)-enhanced fluorescence imaging and chemotherapy of MDR tumors. Generation 5 (G5) poly(amidoamine) dendrimers covalently modified with efflux inhibitor of d -α-tocopheryl polyethylene glycol 1000 succinate (G5-TPGS) were complexed with one-step hydrothermally synthesized y-CDs via electrostatic interaction. The formed G5-TPGS@y-CDs complexes were then physically loaded with anticancer drug doxorubicin (DOX) to generate (G5-TPGS@y-CDs)-DOX complexes. The developed nanohybrids display a high drug loading efficiency (40.7%), strong y-CD-induced fluorescence emission, and tumor microenvironment pH-preferred DOX release profile. Attributing to the DOX/TPGS dual drug design, the (G5-TPGS@y-CDs)-DOX complexes can overcome the multidrug resistance (MDR) of cancer cells and effectively inhibit the growth of cancer cells and tumors. Furthermore, the introduction of US-targeted microbubble destruction technology was proven to render the complexes with enhanced intracellular uptake and anticancer efficacy in vitro and improved chemotherapeutic efficacy and fluorescence imaging of tumors in vivo due to the produced sonoporation effect. The developed multifunctional dendrimer/CD nanohybrids may represent an advanced design of nanomedicine for US-enhanced theranostics of different types of MDR tumors.

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Section: Introductionmentioning

confidence: 99%

Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrug-resistant tumors using multifunctional dendrimer/carbon dot nanohybrids

Lin

Fan

et al. 2021

Bioactive Materials

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“…This facilitation of AuNPs by PPI dendrimers led to mitochondrial rupture, triggering apoptosis. 191 PAMAM dendrimers are significantly used as a platform for the delivery of genomic materials and drugs. 192 PAMAM-based G(5)-D-Ac-TPP dendrimers have been designed for mitochondria targeting in drug delivery.…”

Section: Dendrimersmentioning

confidence: 99%

Novel Strategies for Disrupting Cancer-Cell Functions with Mitochondria-Targeted Antitumor Drug–Loaded Nanoformulations

Allemailem

Almatroudi

Alsahli

et al. 2021

IJN

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Any variation in normal cellular function results in mitochondrial dysregulation that occurs in several diseases, including cancer. Such processes as oxidative stress, metabolism, signaling, and biogenesis play significant roles in cancer initiation and progression. Due to their central role in cellular metabolism, mitochondria are favorable therapeutic targets for the prevention and treatment of conditions like neurodegenerative diseases, diabetes, and cancer. Subcellular mitochondria-specific theranostic nanoformulations for simultaneous targeting, drug delivery, and imaging of these organelles are of immense interest in cancer therapy. It is a challenging task to cross multiple barriers to target mitochondria in diseased cells. To overcome these multiple barriers, several mitochondriotropic nanoformulations have been engineered for the transportation of mitochondria-specific drugs. These nanoformulations include liposomes, dendrimers, carbon nanotubes, polymeric nanoparticles (NPs), and inorganic NPs. These nanoformulations are made mitochondriotropic by conjugating them with moieties like dequalinium, Mito-Porter, triphenylphosphonium, and Mitochondria-penetrating peptides. Most of these nanoformulations are meticulously tailored to control their size, charge, shape, mitochondriotropic drug loading, and specific cell-membrane interactions. Recently, some novel mitochondria-selective antitumor compounds known as mitocans have shown high toxicity against cancer cells. These selective compounds form vicious oxidative stress and reactive oxygen species cycles within cancer cells and ultimately push them to cell death. Nanoformulations approved by the FDA and EMA for clinical applications in cancer patients include Doxil, NK105, and Abraxane. The novel use of these NPs still faces tremendous challenges and an immense amount of research is needed to understand the proper mechanisms of cancer progression and control by these NPs. Here in this review, we summarize current advancements and novel strategies of delivering different anticancer therapeutic agents to mitochondria with the help of various nanoformulations.

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“…Prophyrin dendrimers play a vital role in photodynamic therapy and nano devices due to their unique property of transferring their excitation energy on commotion by light, for instance see: Ethirajan et al (2011), Jeong et al (2012), andO'Connor et al (2009). Different structures and shapes of dendrimers are very useful in the study of transfection, chemotherapy, and gene therapy, for detailed studies see: Bielinska et al (1999), Jain et al (2010), Lakshminarayanan et al (2013), Xiong et al (2018), and Yang et al (2015). Authors of these papers explore bio-distribution and toxicity of dendrimers (and polymers) with dependency on their structures.…”

Section: Introductionmentioning

confidence: 99%

Forgotten coindex of some non-toxic dendrimers structure used in targeted drug delivery

Ali

Bibi

Kiran

2021

Main Group Metal Chemistry

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In recent past, porphyrin-based dendrimers have gained great attraction due to their usefulness in nano devices and photo-dynamic therapy. New technologies based upon nano-materials or dendrimers have potential to overcome the problems due to conventional drug delivery, like toxicity, poor solubility and poor release pattern of drugs. The chemical and physical properties of these highly branched nanometer sized dendrimers depend on their structure. In chemical network theory, various topological indices are used to predict chemical properties of molecules(dendrimers). Among many useful topological descriptors forgotten coindex is relatively less explored but is found very useful in material engineering, pharmaceutical and chemical industries. In this article, we consider some special dendrimers, like poly(propyl) ether imine, porphyrin, and zinc-porphyrin, and nanostars like D 1[k] and D 2[k] and compute forgotten coindex for these important structures.

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Dendrimer-based strategies for cancer therapy: Recent advances and future perspectives

Cited by 57 publications

References 141 publications

Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrug-resistant tumors using multifunctional dendrimer/carbon dot nanohybrids

Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrug-resistant tumors using multifunctional dendrimer/carbon dot nanohybrids

Novel Strategies for Disrupting Cancer-Cell Functions with Mitochondria-Targeted Antitumor Drug–Loaded Nanoformulations

Forgotten coindex of some non-toxic dendrimers structure used in targeted drug delivery

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