Dendrimer-magnetic nanoparticles as multiple stimuli responsive and enzymatic drug delivery vehicle

Chandra, Sudeshna; Noronha, Glen; Dietrich, Sascha; Lang, Heinrich; Bahadur, D.

doi:10.1016/j.jmmm.2014.10.096

Cited by 29 publications

(9 citation statements)

References 20 publications

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“…In this regard, graphene-based magnetic nanomaterials, developed as multifunctional nanocarriers, are able to have a dramatic impact in medicine and in the treatment of cancer. However, the majority of the magnetic drug nanocarriers reported in the literature revealed a low saturation magnetization (M s ) profile [2,11,13,16,17], limiting the utility of these magnetic nanocomposites for magnetic hyperthermia. Also the possible aggregation and precipitation of graphene-based materials in the presence of electrolyte solutions, such as the body fluids [18], is an issue that needs to be addressed.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

Rodrigues

Baldi

Doumett

et al. 2018

Materials Science and Engineering: C

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The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of 91% (w/w, representing 910 μg mg −1) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2.1-2.7 nHm 2 kg −1), and (iii) a dual pH and thermal stimuli-responsive drug controlled release (46% at acidic tumour pH vs 7% at physiological pH) under AC magnetic field, in just 30 min. Additionally, GYSMNP@PF127 presents optimal hydrodynamic diameter (D H = 180 nm) with negative surface charge, high haemocompatibility for blood stream applications and tumour cellular uptake of drug nanocarriers. Due to its physicochemical, magnetic and biocompatibility properties, the developed graphene-based magnetic nanocarrier shows high promise as dual exogenous (AC field)/endogenous (pH) stimuli-responsive actuators for targeted thermo-chemotherapy, combining magnetic hyperthermia and controlled drug release triggered by the abnormal tumour environment. The presented strategy and findings can represent a new way to design and develop highly stable added-value graphene-based nanostructures for the combined treatment of cancer.

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Section: Introductionmentioning

confidence: 99%

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

Rodrigues

Baldi

Doumett

et al. 2018

Materials Science and Engineering: C

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“…Over the past decades, several nano-sized DDSs have been developed and applied by targeted drug delivery to cancer cells, such as liposomes, [4][5][6][7] polymeric micelles, [8][9][10][11] dendrimers, [12][13][14][15][16] carbon nanotubes, [17][18][19][20][21][22] inorganic nanoparticles, [23][24][25][26] and silica-based materials. [27][28][29][30][31] Among them, mesoporous silica nanoparticles (MSNs) have attracted much attention due to their unique physiochemical properties, such as large specific surface area and pore volume, controllable particle size, remarkable stability and biocompatibility, and high drug-loading capacity.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

203

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“…The bioconjugation is made feasible through viable chemical functionalization of magnetic Magnetochemistry 2019, 5, 64 2 of 21 materials to link desired molecular probes for analyte detection in sensors. Chemical and bio sensors constitute one common theme of involving magnetic particle applications [1,[3][4][5][6][7][8][9], and other equally important areas include biomedical imaging [10][11][12][13][14][15][16][17], food science [18][19][20], drug delivery [21][22][23], disease treatment [24,25], nanomedicine [26], diagnostics [27][28][29][30][31][32], catalysis [33][34][35][36][37][38][39][40], separation and purification [41,42], health [43], and environmental applications [44][45][46][47]. Thus, a plethora of studies have been reviewed for the unusually b...…”

Section: Introductionmentioning

confidence: 99%

Magnetic Particle Bioconjugates: A Versatile Sensor Approach

Krishnan

Goud

2019

Magnetochemistry

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: Nanomaterial biosensors have revolutionized the entire scientific, technology, biomedical, materials science, and engineering fields. Among all nanomaterials, magnetic nanoparticles, microparticles, and beads are unique in offering facile conjugation of biorecognition probes for selective capturing of any desired analytes from complex real sample matrices (e.g., biofluids such as whole blood, serum, urine and saliva, tissues, food, and environmental samples). In addition, rapid separation of the particle-captured analytes by the simple use of a magnet for subsequent detection on a sensor unit makes the magnetic particle sensor approach very attractive. The easy magnetic isolation feature of target analytes is not possible with other inorganic particles, both metallic (e.g., gold) and non-metallic (e.g., silica), which require difficult centrifugation and separation steps. Magnetic particle biosensors have thus enabled ultra-low detection with ultra-high sensitivity that has traditionally been achieved only by radioactive assays and other tedious optical sources. Moreover, when traditional approaches failed to selectively detect low-concentration analytes in complex matrices (e.g., colorimetric, electrochemistry, and optical methods), magnetic particle-incorporated sensing strategies enabled sample concentration into a defined microvolume of large surface area particles for a straightforward detection. The objective of this article is to highlight the ever-growing applications of magnetic materials for the detection of analytes present in various real sample matrices. The central idea of this paper was to show the versatility and advantages of using magnetic particles for a variety of sample matrices and analyte types and the adaptability of different transducers with the magnetic particle approaches.

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Dendrimer-magnetic nanoparticles as multiple stimuli responsive and enzymatic drug delivery vehicle

Cited by 29 publications

References 20 publications

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Magnetic Particle Bioconjugates: A Versatile Sensor Approach

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