Dendrimer−Silver Complexes and Nanocomposites as Antimicrobial Agents

Abstract

Silver complexes of poly(amidoamine) (PAMAM) dendrimers as well as different {silver−PAMAM} dendrimer nanocomposite solutions have been tested in vitro against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli bacteria, using the standard agar overlay method. Both PAMAM silver salts and nanocomposites displayed considerable antimicrobial activity without the loss of solubility and activity, even in the presence of sulfate or chloride ions.

Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

“…They have been recognized as excellent antimicrobial agents because of their effective biocide ability and nontoxicity to human cells [2][3][4][5][6]. According to Bonde et al [7] the activity of standard antibiotics was significantly increased in the presence of silver nanoparticles and that can be used effectively against antibiotic-resistant pathogens.…”

Dendrimers as Antibacterial Agents

“…Shielding of the positive charges of the protonated amino groups on the exterior of the dendrimer by the PEG or lauroyl chains is likely the reason for reduced cytotoxicity . Due to their excellent biocompatibility, PEG-modified PAMAM dendrimers have been used as carriers of imaging agents and pharmaceuticals, including antimicrobial agents such as penicillin V and silver (Aymonier et al, 2002;Balogh et al, 2001;Bielinska et al, 1996;Svenson & Tomalia, 2005;Yang & Lopina, 2003). Fig.…”

Self-Organization and Morphological Characteristics of the Selenium Containing Nanostructures on the Base of Strong Polyacids

“…In connection with development of biological nanotechnology the above mentioned particles represent interest as active ingredients of medicines [2,3] as well as transport systems and adsorption matrixes for bioactive substances [4].…”