Dendrimers: A versatile nanocarrier for drug delivery and targeting

Sherje, Atul P.; Jadhav, Mrunal; Dravyakar, Bhushan R.; Kadam, Darshana

doi:10.1016/j.ijpharm.2018.07.030

Cited by 296 publications

(171 citation statements)

References 184 publications

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“…The terminal groups (also called functional groups or surface groups) are responsible for the interaction of the dendrimers with the external groups or molecules. Consequently, the physicochemical properties of dendrimers depend not only on the branching units, but also on the surface functional groups [25]. As the control of the physicochemical properties of these structures can be achieved during synthesis by controlling the core groups, the extent of branching, and the nature and/or number of terminal groups on the surface, dendrimers became popular in the NMs research area [26].…”

Section: Introductionmentioning

confidence: 99%

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

2019

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The European Medicines Agency (EMA) and the Current Good Manufacturing Practices (cGMP) in the United States of America, define excipient as the constituents of the pharmaceutical form other than the active ingredient, i.e., any component that is intended to furnish pharmacological activity. Although dendrimers do not have a pharmacopoeia monograph and, therefore, cannot be recognized as a pharmaceutical excipient, these nanostructures have received enormous attention from researchers. Due to their unique properties, like the nanoscale uniform size, a high degree of branching, polyvalency, aqueous solubility, internal cavities, and biocompatibility, dendrimers are ideal as active excipients, enhancing the solubility of poorly water-soluble drugs. The fact that the dendrimer’s properties are controllable during their synthesis render them promising agents for drug-delivery applications in several pharmaceutical formulations. Additionally, dendrimers can be used for reducing the drug toxicity and for the enhancement of the drug efficacy. This review aims to discuss the properties that turn dendrimers into pharmaceutical excipients and their potential applications in the pharmaceutical and biomedical fields.

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Section: Introductionmentioning

confidence: 99%

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

2019

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“…A triazole-base dendrimer contained bile acid surface groups was synthesized by "click" chemistry strategy [34]. In addition, "Janus" dendrimers and "onion peel" were obtained using this strategy [35]. Pérez-Campos et al has synthesized two different dendrimeric structures and the precursor dendron with aimed to evaluate their role in the antichagasic activity as drug carriers and as prodrugs.…”

Section: "Click" Chemistry Strategymentioning

confidence: 99%

“…The different kinds of cancer that afflict the population are the leading cause of death worldwide. Despite the significant advances in medicine, there are still many challenges to be achieved in the treatment of cancer, to name a few, namely to decrease the side effects of some drugs [97,98], drug solubility improvement [76], drug-resistant cancer cell [84], and achieve a transport and targeted release of the drug [35]. Some of these advances focus on the use of dendritic nanoparticles as vehicles for the targeted transport of drugs against various types of cancer [85].…”

Section: Dendrimer As Drug Delivery Systems To Cancer Treatmentsmentioning

confidence: 99%

Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems

Sandoval-Yáñez

Rodríguez

2020

Materials

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Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.

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“…The uniqueness of dendrimers stems from their multibranched, three-dimensional architecture, coupled with low polydispersity and great functionality (Sherje et al 2018). There are many apparent advantages to the utilisation of dendrimers as non-viral vectors for therapeutic indications, as opposed to other nanotechnologies.…”

Section: Dendrimersmentioning

confidence: 99%

The use of nanotechnology in cardiovascular disease

2018

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Cardiovascular diseases claim a number of lives globally; many of which are preventable. With the increase in diets that consist of high saturated fat, salt, and sugar, people often living sedentary lifestyles, and a rise in cases of obesity, the incidence of cardiovascular disease is increasing. These contributing factors, coupled with more advanced methods of diagnosis, have delivered statistics that clearly show that there is a rising trend in the prevalence of cardiovascular disease. Treatment for cardiovascular diseases is limited currently to oral medicines or invasive surgery. There is a huge gap in this area of medicine for novel therapeutics for improved patient outcomes. Nanotechnology may provide a solution to more effective treatment of disease, with better prognoses and a reduced side effect profile. This review will explore for potential solutions to the limited pharmacological therapies currently on the market and the future that lies ahead for the place of nanotechnology within cardiovascular medicine.

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Dendrimers: A versatile nanocarrier for drug delivery and targeting

Cited by 296 publications

References 184 publications

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems

The use of nanotechnology in cardiovascular disease

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