Dendrimers and hyperbranched structures for biomedical applications

Pedziwiatr-Werbicka, Elzbieta; Miłowska, Katarzyna; Dzmitruk, Volha; Йонов, Максим; Shcharbin, Dzmitry; Bryszewska, Maria

doi:10.1016/j.eurpolymj.2019.07.013

Cited by 116 publications

(63 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The term "polyamidoamine dendrimers" (PAMAM) is classically intended to refer to dendrimers comprised of (i) a core (earliest core: an ethylenediamine core), (ii) branches made up of amide groups emanating from a branching point that forms the walls of cavities, and (iii) amine functional groups on the periphery (Figure 1b). Concurrently, there is a large selection of PAMAM dendrimers with disparate surface groups [40]. PAMAM dendrimers, one of the most fully studied dendrimers, possess internal cavities and peripheral functional groups, which can be further modified to encapsulate agents or other cargos for biomedical applications.…”

Section: Pamam Dendrimersmentioning

confidence: 99%

Dendrimer-Based Drug Delivery Systems for Brain Targeting

2019

View full text Add to dashboard Cite

Human neuroscience has made remarkable progress in understanding basic aspects of functional organization; it is a renowned fact that the blood–brain barrier (BBB) impedes the permeation and access of most drugs to central nervous system (CNS) and that many neurological diseases remain undertreated. Therefore, a number of nanocarriers have been designed over the past few decades to deliver drugs to the brain. Among these nanomaterials, dendrimers have procured an enormous attention from scholars because of their nanoscale uniform size, ease of multi-functionalization, and available internal cavities. As hyper-branched 3D macromolecules, dendrimers can be maneuvered to transport diverse therapeutic agents, incorporating small molecules, peptides, and genes; diminishing their cytotoxicity; and improving their efficacy. Herein, the present review will give exhaustive details of extensive researches in the field of dendrimer-based vehicles to deliver drugs through the BBB in a secure and effectual manner. It is also a souvenir in commemorating Donald A. Tomalia on his 80th birthday.

show abstract

Section: Pamam Dendrimersmentioning

confidence: 99%

Dendrimer-Based Drug Delivery Systems for Brain Targeting

2019

View full text Add to dashboard Cite

show abstract

“…Since their discovery, the well-defined architecture of dendrimers has promoted their use thanks to their highly multifunctional skeleton, which not only allows for the concentration of a high number of units of interest in the same structure but also permits fragments of a different nature to be introduced, combining both properties. Therefore, the introduction of different types of fragment enables change in the physicochemical properties of the dendritic structure, yielding molecules with relevance in diverse fields such as catalysis [1], material science [2] or biomedicine [3].…”

Section: Introductionmentioning

confidence: 99%

New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

et al. 2020

View full text Add to dashboard Cite

The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of 19F magnetic resonance imaging (19F-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by 19F-MRI.

show abstract

“…Dendrimers are a relatively new class of polymer material and have been studied extensively over recent years for their use in biomedicine [1][2][3] or to design sensor systems. [4,5] They are nanosized compounds with a well defined chemical structure and monodispersed three-dimensional globular forms, characterized by their combining of the properties of low-and high-molecular-weight compounds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral properties and antimicrobial activity of a new cationic water‐soluble pH‐dependent poly(propylene imine) dendrimer modified with 1,8‐naphthalimides

et al. 2020

View full text Add to dashboard Cite

A three‐step synthesis was implemented to prepare a quaternary ammonium functionalized blue fluorescent poly(propylene imine) dendrimer modified with pyridinium salt of 4‐acylamino‐1,8‐naphthalimide. The new cationic dendrimer absorbs in the ultraviolet light region and emits blue fluorescence. Its spectral characteristics in organic solvents and in an aqueous solution were studied. The influence of pH on the fluorescence intensity of the dendrimer was established with regard to its use as a pH sensor. The effect of hydroxyl ions on the absorption and fluorescence spectra in dry N,N‐dimethylformamide was also investigated. The antimicrobial activity of the dendrimer was assessed against model pathogenic microorganisms in agar, liquid medium, and after its deposition on cotton fabric.

show abstract

Dendrimers and hyperbranched structures for biomedical applications

Cited by 116 publications

References 168 publications

Dendrimer-Based Drug Delivery Systems for Brain Targeting

Dendrimer-Based Drug Delivery Systems for Brain Targeting

New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

Synthesis, spectral properties and antimicrobial activity of a new cationic water‐soluble pH‐dependent poly(propylene imine) dendrimer modified with 1,8‐naphthalimides

Contact Info

Product

Resources

About