Dendrimers as Novel Polymeric Material: A Review on Its Synthesis, Characterization and Their Applications

Nasibullah, Malik; Hassan, F.; Ahmad, Naseem; Khan, A. R.; Rahman, Masihur

doi:10.1166/asfo.2013.1040

Cited by 6 publications

(3 citation statements)

References 72 publications

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“…The first completely characterized repetitively branched and polyfuctional molecule was generated by Vogtle et al in 1978 from a protocol based on cycles of nucleophile amine addition to electron-poor cyanoalkene, followed by reduction of the cyano groups which in turn yields new amine moieties for further reactions (Buhleier, Wehner and Vögtle, 1978). Several other contributions like Vogtle's, particularly those form the research groups of Newkome, Denkwalter and Tomalia (Denkewalter, Kolc and Lukasavage, 1982;Newkome, Yao, Baker and Gupta, 1985;Tomalia et al, 1985) build upon experiments setting out some fundamental principles of molecular organisation pioneered by P.J Flory in the middle of the twentieth century (Flory, 1942) Extensive research into the possible applications of dendrimers in diverse areas within the biological and medical fields is currently ongoing (Caron et al, 2010;Mintzer and Grinstaff, 2011;Nasibullah, Hassan, Ahmad, Khan and Rahman, 2013;Noriega-Luna et al, 2014). Some properties of dendrimers including their nanoscopic size and uniformity, flexible molecular structure and presence of multiple peripheral functional groups to facilitate conjugate formation with a wide range of drug molecules make dendrimers highly suited for targeted delivery of drugs (Kesharwani, Jain and Jain, 2014), and hence the rigorous investigations into their potential as drug delivery systems, especially in the area of cancer pharmacotherapy and delivery of macromolecules (Brannon-Peppas and Blanchette, 2012;Cheng, Zhao, Li and Xu, 2011;Lim and Simanek, 2012;Parhi et al, 2012;Parveen, Misra and Sahoo, 2012).…”

Section: Dendrimers For Microbicidesmentioning

confidence: 99%

“…Extensive research into the possible applications of dendrimers in diverse areas within the biological and medical fields is currently ongoing (Caron et al 2010, Mintzer and Grinstaff 2011, Nasibullah et al 2013, Noriega-Luna et al 2014. Some properties of dendrimers including their nanoscopic size and uniformity, flexible molecular structure and presence of multiple peripheral functional groups to facilitate conjugate formation with a wide range of drug molecules make dendrimers highly suited for targeted delivery of drugs (Kesharwani et al 2014), and hence the rigorous investigations into their potential as drug delivery systems, especially in the area of cancer pharmacotherapy and delivery of macromolecules (Cheng et al 2011, Brannon-Peppas and Blanchette 2012, Lim and Simanek, 2012, Parhi et al 2012, Parveen et al 2012.…”

Section: Modulating Drug Releasementioning

confidence: 99%

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Application of nanotechnology for the development of microbicides

et al. 2016

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The vaginal route is increasingly being considered for both local and systemic delivery of drugs, especially those unsuitable for oral administration. One of the opportunities offered by this route but yet to be fully utilised is the administration of microbicides. Microbicides have an unprecedented potential for mitigating the global burden from HIV infection as heterosexual contact accounts for most of the new infections occurring in sub-Saharan Africa, the region with the highest prevalent rates. Decades of efforts and massive investment of resources into developing an ideal microbicide have resulted in disappointing outcomes, as attested by several clinical trials assessing the suitability of those formulated so far. The highly complex and multi-level biochemical interactions that must occur among the virus, host cells and the drug for transmission to be halted means that a less sophisticated approach to formulating a microbicide e.g. conventional gels, etc may have to give way for a different formulation approach. Nanotechnology has been identified to offer prospects for fabricating structures with high capability of disrupting HIV transmission. In this review, predominant challenges seen in microbicide development have been highlighted and possible ways of surmounting them suggested. Furthermore, formulations utilising some of these highly promising nanostructures such as liposomes, nanofibres and nanoparticles have been discussed. A perspective on how a tripartite collaboration among governments and their agencies, the pharmaceutical industry and academic scientists to facilitate the development of an ideal microbicide in a timely manner has also been briefly deliberated.

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