Dendrimers in combination with natural products and analogues as anti-cancer agents

Mignani, Serge; Rodrigues, João; Tomás, Helena; Zabłocka, Maria; Shi, Xiangyang; Caminade, Anne‐Marie; Majoral, Jean Pierre

doi:10.1039/c7cs00550d

Cited by 177 publications

(123 citation statements)

References 158 publications

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“…Various agents derived from natural compounds are one of the promising materials being considered to be used to reverse MDR . Biologically active natural products, which are extracted, purified, and characterized from various sources including plants, fungi, and even marine organisms, have some important properties such as low toxicity and are well‐tolerated in the human body . A detailed list of key natural product modulators, which reverse MDR by various mechanisms, is provided in Table .…”

Section: Novel Strategies Against Mdrmentioning

confidence: 99%

Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

Majidinia

Mirza-Aghazadeh-Attari

Rahimi

et al. 2020

IUBMB Life

124

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Multidrug resistance (MDR), defined as the ability of cancer cells to gain resistance to both conventional and novel chemotherapy agents, is an important barrier in treating malignancies. Initially, it was discovered that cellular pumps dependent on ATP were the cause of resistance to chemotherapy, and further studies have found that other mechanisms such as increased metabolism of drugs, decreased drug entry, and defective apoptotic pathways are involved in this process. MDR has been the focus of numerous initiatives and countless studies have been undertaken to better understand MDR and formulate strategies to overcome its effects. The current review highlights various nano‐drug delivery systems including polymeric/solid lipid/mesoporous silica/metal nanoparticles, dendrimers, liposomes, micelles, and nanostructured lipid carriers to overcome the mechanism of MDR. Nanoparticles are novel gateways to enhance the therapeutic efficacy of anticancer agents at the target site of action due to their tumor‐targeting abilities, which can limit the unwanted systemic effects of chemotherapy agents and also reduce drug resistance. Additionally, other innovative strategies including RNA interference as a biological process used to inhibit or silence specific gene expression, natural products as MDR modulators with little systemic toxic effects, which interfere with the functions of proteins involved in drug efflux, and physical approaches such as combination of conventional drug administration with thermal/ultrasound/photodynamic strategies are also highlighted.

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Section: Novel Strategies Against Mdrmentioning

confidence: 99%

Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

Majidinia

Mirza-Aghazadeh-Attari

Rahimi

et al. 2020

IUBMB Life

124

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“…Within the myriad of nanoparticles developed in nanomedicine, dendrimers, which are highly monodisperse, branched (multidirectional branches), star‐shaped macromolecules with nanometer‐scale dimensions and a carefully tailored architecture, have gained a broad range of applications, including medicinal applications (Kannan, Nance, Kannan, & Tomalia, ; Rolland, Turrin, Caminade, & Majoral, ), mainly in drug delivery (Medina & El‐Sayed, ; Mignani & Majoral, ; Mignani et al, ). The drugs can be encapsulated within the dendrimer interior or conjugated onto the dendrimer surface.…”

Section: Introductionmentioning

confidence: 99%

Metal‐based phosphorus dendrimers as novel nanotherapeutic strategies to tackle cancers: A concise overview

Chen

Mignani

Caminade

et al. 2019

WIREs Nanomed Nanobiotechnol

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Several metal‐based phosphorus dendrimers were prepared. The first series developed by us was the Cu(II) series. In this series, the most potent is the third generation‐Cu(II) showing original mechanism of action with activation of the pro‐apoptotic Bax protein. To our knowledge, it is the first example of nanoparticles displaying Bax protein activation and then cell death through apoptosis process. Interestingly, this dendritic‐Cu(II) complex showed synergistic effect with doxorubicin. Based on these interesting anti‐proliferative activities, we developed Au(III)‐conjugated phosphorus dendrimers. The most potent is the third generation‐Au(III) dendrimer which represents also a new and promising first‐in‐class anti‐proliferative agent against both solid and liquid tumor cell lines. Then, in order to analyze the influence of the metal moiety distribution of Cu(II) and Au(III) on the surface of dendrimers, mix Cu(II)–Au(III)‐conjugated phosphorus dendrimers were also prepared and tested as anti‐proliferative agents. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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“…Those locations are able to host either metallic nanoparticles (NPs) or organometallic complexes for homogeneous‐like catalytic applications . Dendrimers can also fulfill the role of encapsulating vectors in the field of nanomedicine and are intensively studied in drug delivery systems …”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25][26][27][28][29] Dendrimersc an also fulfill the role of encapsulating vectors in the field of nanomedicine and are intensively studied in drug delivery systems. [26,[30][31][32][33][34][35][36][37][38] The combination of NCs and PAMAM gives various advantages.F irst of all,d endrimers significantly increase the dispersibility of the carbonaceous material and therefore favor its handling and processability.S econdly,d endrimers facet he usual drawbacks of homogeneousc atalytic systems: theya re tedious to recover and recycle. This is especially true for small-size dendrimers.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Catalytic Applications of Multi‐Walled Carbon Nanotube–Polyamidoamine Dendrimer Hybrids

Desmecht

Steenhaut

Pennetreau

et al. 2018

Chemistry A European J

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Polyamidoamine (PAMAM) dendrimers were covalently immobilized on multi-walled carbon nanotubes (MWNT) by two "grafting to" strategies. We demonstrate the existence of non-covalent interactions between the two components but outline the superiority of our two grafting approaches, namely xanthate and click chemistry. MWNT surfaces were functionalized with activated ester and propargylic moieties prior to their reaction with PAMAM or azido-PAMAM dendrimers, respectively. The grafting of PAMAM generations 0 to 3 was evaluated with X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The versatility of our hybrids was demonstrated by post-functionalization sequences involving copper alkyne-azide cycloaddition (CuAAC). We synthesized homogeneous supported iridium complexes at the extremities of the dendrimers. In addition, our materials were used as templates for the encapsulation of Pd nanoparticles (NPs), validating our nanocomposites for catalytic applications. The palladium-based catalyst was active for carbonylative coupling over five consecutive runs without loss of activity.

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Dendrimers in combination with natural products and analogues as anti-cancer agents

Cited by 177 publications

References 158 publications

Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

Metal‐based phosphorus dendrimers as novel nanotherapeutic strategies to tackle cancers: A concise overview

Synthesis and Catalytic Applications of Multi‐Walled Carbon Nanotube–Polyamidoamine Dendrimer Hybrids

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