Dendrimers in vaccine delivery: Recent progress and advances

Chowdhury, Silvia; Tóth, István; Stephenson, Rachel J.

doi:10.1016/j.biomaterials.2021.121303

Cited by 59 publications

(36 citation statements)

References 137 publications

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“…The nanometer size of dendrimer molecules comparable to that of the drug delivery systems facilitates their application in medical technologies [12]. They can form 10-500 nm nanoparticles, which well penetrate the cells and promote the immune response [13][14][15]. Such aggregates have been proposed as promising drug delivery systems due to the ability to covalently and noncovalently bind guest molecules and penetrate the bloodbrain barrier [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…H NMR (CD 3 OD, δ, ppm, J/Hz): 1 14. (s, 36H, (CH 3 ) 3 C), 1.35 (m, 16H, C(O)NHCH 2 CH 2 CH 2 CH 2 ), 1.50 (m, 8H, CH 2 CH 2 CH 2 N), 1.60 (m, 8H, C(O)NHCH 2 CH 2 CH 2 ), 2.38 (t, 16H, NCH 2 CH 2 C(O)NH, 3 J HH = 7.0), 2.41-2.50 (m, 40H, CH 2 CH 2 CH 2 N, NCH 2 CH 2 C(O)OCH 3 ), 2.55 (t, 16H, NHCH 2 CH 2 N, 3 J HH = 6.3), 2.70-2.83 (m, 48H, NCH 2 CH 2 C(O)), 3.25 (t, 16H, NHCH 2 CH 2 N, 3 J HH = 6.3), 3.33 (m, 8H, NHCH 2 CH 2 CH 2 ), 3.66 (s, 48H, OCH 3 ), 4.89 (s, 8H, OCH 2 C(O)), 7.45 (s, 8H, ArH).…”

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confidence: 99%

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PAMAM-Calix-Dendrimers: Second Generation Synthesis, Fluorescent Properties and Catecholamines Binding

et al. 2022

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A convenient method for the synthesis of the second generation of PAMAM dendrimers based on a p-tert-butylthiacalix[4]arene core in cone, partial cone and 1,3-alternate conformations was developed. Unusual fluorescence of the obtained PAMAM-calix-dendrimers has been found and explained. The binding ability of the synthesized dendrimers toward catecholamines (dopamine, L-adrenaline and L-noradrenaline) was shown by UV-Vis, fluorescence, 1D and 2D NMR spectroscopy and the binding constants (logKa 3.85–4.74) calculated. As was shown, the PAMAM-calix-dendrimers bind catecholamines by the internal cavities. All the studied hormones were most efficiently bound by the dendrimers bearing a macrocyclic core in 1,3-alternate conformation. The size of the formed supramolecular systems of dendrimer/catecholamine was established by the DLS method. A decrease in hemolytic activity of the PAMAM-calix-dendrimers with an increase in the generation number of a dendrimer was shown for the dendrimers with a core in 1,3-alternate conformation. The prospects for the use of the synthesized dendrimers with the macrocyclic core as drug delivery agents were discussed.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

PAMAM-Calix-Dendrimers: Second Generation Synthesis, Fluorescent Properties and Catecholamines Binding

et al. 2022

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“…Another polymer that has been utilized is polyamidoamine (PAMAM), which is a cationic polymer. The PAMAM dendrimer has been used to deliver intramuscular self-amplifying mRNA-based vaccination against Toxoplasma gondii, Ebola and H1N1 influenza virus [ 91 , 94 ].…”

Section: Delivery Vehiclementioning

confidence: 99%

The Delivery of mRNA Vaccines for Therapeutics

Nitika

Wei

Hui

2022

Life

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mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers. For effective vaccination, mRNA formulation, delivery method and composition of the mRNA carrier play an important role. mRNA vaccines can be delivered using lipid nanoparticles, polymers, peptides or naked mRNA. The vaccine efficacy is influenced by the appropriate delivery materials, formulation methods and selection of a proper administration route. In addition, co-delivery of several mRNAs could also be beneficial and enhance immunity against various variants of an infectious pathogen or several pathogens altogether. Here, we review the recent progress in the delivery methods, modes of delivery and patentable mRNA vaccine technologies.

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“…In addition, poly-amino acids, such as poly(γ-glutamic acid) (γ-PGA) [ 40 ], poly(ε-lysine) [ 41 ] or poly(L-arginine) [ 42 ], and polysaccharides such as chitosan, alginate or dextran [ 43 , 44 , 45 , 46 , 47 ], have also been developed. Dendrimers (usually olypropyleneimine (PPI) and polyamido amine (PAMAM) dendrimers) are also attractive platforms due to their well-defined branched structure and structural versatility that offer the possibility of encapsulating or coupling functional vaccine antigens [ 48 , 49 , 50 , 51 , 52 ]. Additionally, inorganic compounds such as gold (AuNPs), silver (AgNPs) [ 53 , 54 , 55 ], silica [ 56 ] or carbon [ 57 ] can be used for the safe, reproducible and low-cost generation of nanosized structures for enhanced antigen delivery [ 52 ].…”

Section: Nanoparticle- and Microparticle-based Vaccine Platformsmentioning

confidence: 99%

Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance

et al. 2022

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Bluetongue virus (BTV) and African horse sickness virus (AHSV) are widespread arboviruses that cause important economic losses in the livestock and equine industries, respectively. In addition to these, another arthropod-transmitted orbivirus known as epizootic hemorrhagic disease virus (EHDV) entails a major threat as there is a conducive landscape that nurtures its emergence in non-endemic countries. To date, only vaccinations with live attenuated or inactivated vaccines permit the control of these three viral diseases, although important drawbacks, e.g., low safety profile and effectiveness, and lack of DIVA (differentiation of infected from vaccinated animals) properties, constrain their usage as prophylactic measures. Moreover, a substantial number of serotypes of BTV, AHSV and EHDV have been described, with poor induction of cross-protective immune responses among serotypes. In the context of next-generation vaccine development, antigen delivery systems based on nano- or microparticles have gathered significant attention during the last few decades. A diversity of technologies, such as virus-like particles or self-assembled protein complexes, have been implemented for vaccine design against these viruses. In this work, we offer a comprehensive review of the nano- and microparticulated vaccine candidates against these three relevant orbiviruses. Additionally, we also review an innovative technology for antigen delivery based on the avian reovirus nonstructural protein muNS and we explore the prospective functionality of the nonstructural protein NS1 nanotubules as a BTV-based delivery platform.

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Dendrimers in vaccine delivery: Recent progress and advances

Cited by 59 publications

References 137 publications

PAMAM-Calix-Dendrimers: Second Generation Synthesis, Fluorescent Properties and Catecholamines Binding

PAMAM-Calix-Dendrimers: Second Generation Synthesis, Fluorescent Properties and Catecholamines Binding

The Delivery of mRNA Vaccines for Therapeutics

Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance

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