Dendritic branching features of Golgi-impregnated neurons from the “ventral” medial amygdala subnuclei of adult male and female rats

Dall'Oglio, Aline; Gehlen, Günther; Achaval, Matilde; Rasia‐Filho, Alberto A.

doi:10.1016/j.neulet.2008.05.025

Cited by 27 publications

(20 citation statements)

References 22 publications

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“…Based on cytoarchitectual, hodological, and functional criteria, the MeA was divided into the anterodorsal (MeAD), the anteroventral (MeAV), the MePD, and the posteroventral (MePV) subnuclei (Newman, 1999;Petrovich et al, 2001;de Olmos et al, 2004;Dall'Oglio et al, 2008). Taste and visceral sensory information can reach the MeA coming from the pontine parabrachial nucleus (Berthoud, 2002;Knapska et al, 2007).…”

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confidence: 99%

Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Rosa¹,

Goularte²,

Trindade³

et al. 2011

The Anatomical Record

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Previous studies have involved the ''posterodorsal'' amygdaloid area with the control of food intake and the development of obesity in rats. Within this wide region, the posterodorsal medial amygdala (MePD) has connections with specific hypothalamic nuclei that increase feeding behavior and modulate energy balance. Glutamate is the major brain excitatory neurotransmitter, remarkably enhances centrally mediated food consumption, and is abundantly found in the MePD. Here, it was studied the effects of saline (0.3 lL) and glutamate (45 nM or 45 mM/0.3 lL) directly microinjected in the MePD of adult male rats on the consumption of a three-choice (high-carbohydrate, high-protein, or high-lipid) macronutrient selective diet. The rat adaptation to the experimental procedures and its body weight gain were continuously evaluated. Control data for all groups and results following microinjections were obtained after a fasting protocol. Feeding behavior was evaluated during the subsequent 2-hr period of free access to the selective diets. Both doses of glutamate microinjected in the MePD did not lead to a higher percentage of animals consuming any of the different diets (P > 0.05), although glutamate 45 mM induced a higher consumption of the high-carbohydrate diet when compared with presurgery control values (P < 0.01). Interestingly, present data indicate that glutamate in the male MePD induces only a subtle modification in the feeding behavior and suggest that large electrolytic lesions of the ''posterodorsal'' amygdaloid region might have affected other regions to alter drastically meal size consumption in rats. Anat Rec, 294:1226Rec, 294: -1232Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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confidence: 99%

Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Rosa¹,

Goularte²,

Trindade³

et al. 2011

The Anatomical Record

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“…When mapping the neuronal activation induced by pheromonal detection, we used the nomenclature proposed by Paxinos and Watson [30] and by de Olmos et al [10]. The BAOT nucleus is a small column of small, loosely packed cells closely associated with the accessory olfactory tract [10].…”

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confidence: 99%

“…The BAOT nucleus is a small column of small, loosely packed cells closely associated with the accessory olfactory tract [10].…”

Section: Nomenclaturementioning

confidence: 99%

“…A neuroanatomical theory of this structure has been proposed by de Olmos et al [10], known as the extended amygdala. On the basis of experimental anatomical data, this brain area was divided into two parallel rings termed medial (MEXA) and central extended amygdala.…”

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confidence: 99%

“…The MEXA is made up of the medial amygdaloid nucleus (MeA) and the medial division of the bed nucleus of the stria terminalis (BSTM) [10]. It participates in the processing of pheromonal signals concerned with the control and modulation of neuroendocrine, appetitive, reproductive, and emotional behaviors [20].…”

Section: Introductionmentioning

confidence: 99%

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Detection of conspecific pheromones elicits fos expression in GABA and calcium-binding cells of the rat vomeronasal system–medial extended amygdala

2010

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The olfactory accessory system is specialized in the detection of pheromones, being an afferent to medial extended amygdala. In spite of the fact that numerous phenotypes are found in these structures, in the current literature, there are no detailed descriptions about the phenotype of neurons in the vomeronasal system-medial extended amygdala after their activation by pheromonal stimuli. Using immunohistochemistry for fos and dual immunohistochemistry for fos and phenotypes, here we show that females have a greater number of activated neurons by the pheromonal stimulus. Likewise, a great colocalization of fos with GABA, calretinin, and calbindin was observed in the vomeronasal system-medial extended amygdala. These data suggest that in amygdaloid areas, neuronal excitability is controlled by GABAergic neurons that contain different calcium-binding proteins, indicating the important role of inhibitory control on the incoming sensory pheromonal and olfactory inputs controlled and processed by the vomeronasal system.

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Cellular components of the human medial amygdaloid nucleus

Dall'Oglio

Xavier

Hilbig³

et al. 2012

J of Comparative Neurology

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The medial nucleus (Me) is a superficial component of the amygdaloid complex. Here we assessed the density and morphology of the neurons and glial cells, the glial fibrillary acidic protein (GFAP) immunoreactivity, and the ultrastructure of the synaptic sites in the human Me. The optical fractionator method was applied. The Me presented an estimated mean neuronal density of 1.53 × 10⁵ neurons/mm³ (greater in the left hemisphere), more glia (72% of all cells) than neurons, and a nonneuronal:neuronal ratio of 2.7. Golgi-impregnated neurons had round or ovoid, fusiform, angular, and polygonal cell bodies (10-30 μm in diameter). The length of the dendrites varied, and pleomorphic spines were found in sparsely spiny or densely spiny cells (1.5-5.2 spines/dendritic μm). The axons in the Me neuropil were fine or coarsely beaded, and fibers showed simple or notably complex collateral terminations. The protoplasmic astrocytes were either isolated or formed small clusters and showed GFAP-immunoreactive cell bodies and multiple branches. Furthermore, we identified both asymmetrical (with various small, clear, round, electron-lucent vesicles and, occasionally, large, dense-core vesicles) and symmetrical (with small, flattened vesicles) axodendritic contacts, also including multisynaptic spines. The astrocytes surround and may compose tripartite or tetrapartite synapses, the latter including the extracellular matrix between the pre- and the postsynaptic elements. Interestingly, the terminal axons exhibited a glomerular-like structure with various asymmetrical contacts. These new morphological data on the cellular population and synaptic complexity of the human Me can contribute to our knowledge of its role in health and pathological conditions.

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Dendritic branching features of Golgi-impregnated neurons from the “ventral” medial amygdala subnuclei of adult male and female rats

Cited by 27 publications

References 22 publications

Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Detection of conspecific pheromones elicits fos expression in GABA and calcium-binding cells of the rat vomeronasal system–medial extended amygdala

Cellular components of the human medial amygdaloid nucleus

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