Dendritic Cell and Cancer Therapy

Galati, Domenico; Zanotta, Serena

doi:10.3390/ijms24044253

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…DCs are the most potent and versatile professional antigen-presenting cells (APCs), that can initiate the adaptive immune response and support innate immunity [ 90 ]. DCs can be divided into plasmacytoid DCs (pDCs) and conventional DCs (cDCs) [ 91 , 92 ].…”

Section: The Interplay Between the Immune System And The Gut Microbiotamentioning

confidence: 99%

Critical role of the gut microbiota in immune responses and cancer immunotherapy

Li,

Xiong,

Liang

et al. 2024

J Hematol Oncol

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The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there has been accumulating evidence of the connections between the gut microbiota and cancer immunotherapy. Therefore, understanding the functional role of the gut microbiota in regulating immune responses to cancer immunotherapy is crucial for developing precision medicine. In this review, we extract insights from state-of-the-art research to decipher the complicated crosstalk among the gut microbiota, the systemic immune system, and immunotherapy in the context of cancer. Additionally, as the gut microbiota can account for immune-related adverse events, we discuss potential interventions to minimize these adverse effects and discuss the clinical application of five microbiota-targeted strategies that precisely increase the efficacy of cancer immunotherapy. Finally, as the gut microbiota holds promising potential as a target for precision cancer immunotherapeutics, we summarize current challenges and provide a general outlook on future directions in this field.

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Section: The Interplay Between the Immune System And The Gut Microbiotamentioning

confidence: 99%

Critical role of the gut microbiota in immune responses and cancer immunotherapy

Li,

Xiong,

Liang

et al. 2024

J Hematol Oncol

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“…Antigen presentation is enabled by immune components such as macrophages, Langerhans cells, and B-lymphocytes. In addition, a superior approach involves the use of DCs, as they induce adaptive immunity and support the innate immune response against tumors[ 170 , 171 ]. DCs-based therapy utilizes the first and second classes of major histocompatibility complex (MHC) to stimulate the patient’s immune system and counteract tumor[ 172 , 173 ].…”

Section: Novel Cancer Therapiesmentioning

confidence: 99%

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

Gromek,

Senkowska,

Płuciennik

et al. 2024

World J Methodol

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In accordance with the World Health Organization data, cancer remains at the forefront of fatal diseases. An upward trend in cancer incidence and mortality has been observed globally, emphasizing that efforts in developing detection and treatment methods should continue. The diagnostic path typically begins with learning the medical history of a patient; this is followed by basic blood tests and imaging tests to indicate where cancer may be located to schedule a needle biopsy. Prompt initiation of diagnosis is crucial since delayed cancer detection entails higher costs of treatment and hospitalization. Thus, there is a need for novel cancer detection methods such as liquid biopsy, elastography, synthetic biosensors, fluorescence imaging, and reflectance confocal microscopy. Conventional therapeutic methods, although still common in clinical practice, pose many limitations and are unsatisfactory. Nowadays, there is a dynamic advancement of clinical research and the development of more precise and effective methods such as oncolytic virotherapy, exosome-based therapy, nanotechnology, dendritic cells, chimeric antigen receptors, immune checkpoint inhibitors, natural product-based therapy, tumor-treating fields, and photodynamic therapy. The present paper compares available data on conventional and modern methods of cancer detection and therapy to facilitate an understanding of this rapidly advancing field and its future directions. As evidenced, modern methods are not without drawbacks; there is still a need to develop new detection strategies and therapeutic approaches to improve sensitivity, specificity, safety, and efficacy. Nevertheless, an appropriate route has been taken, as confirmed by the approval of some modern methods by the Food and Drug Administration.

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“…Dendritic cells (DCs) are responsible for antigen presentation in vivo and play an important role in initiating, regulating, and maintaining the immune response [ 101 , 102 ]. They recognize and internalize tumor antigens, process them intracellularly, and expose them on the cell surface as antigenic peptide major histocompatibility complex (pMHC) molecules that are presented to T lymphocytes and activate antigen-specific immunity to eliminate tumor cells [ 103 , 104 ].…”

Section: Classification Of Cmbndsmentioning

confidence: 99%

Cell Membrane Biomimetic Nano-Delivery Systems for Cancer Therapy

Xia,

Mu,

Yuan

et al. 2023

Pharmaceutics

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Nano-delivery systems have demonstrated great promise in the therapy of cancer. However, the therapeutic efficacy of conventional nanomedicines is hindered by the clearance of the blood circulation system and the physiological barriers surrounding the tumor. Inspired by the unique capabilities of cells within the body, such as immune evasion, prolonged circulation, and tumor-targeting, there has been a growing interest in developing cell membrane biomimetic nanomedicine delivery systems. Cell membrane modification on nanoparticle surfaces can prolong circulation time, activate tumor-targeting, and ultimately improve the efficacy of cancer treatment. It shows excellent development potential. This review will focus on the advancements in various cell membrane nano-drug delivery systems for cancer therapy and the obstacles encountered during clinical implementation. It is hoped that such discussions will inspire the development of cell membrane biomimetic nanomedical systems.

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Dendritic Cell and Cancer Therapy

Abstract: Dendritic cells (DCs) are acknowledged as the most potent professional antigen-presenting cells (APCs), able to induce adaptive immunity and support the innate immune response [...]

Cited by 11 publications

References 8 publications

Critical role of the gut microbiota in immune responses and cancer immunotherapy

Critical role of the gut microbiota in immune responses and cancer immunotherapy

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

Cell Membrane Biomimetic Nano-Delivery Systems for Cancer Therapy

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