Dendritic cell-mediated NK cell activation is controlled by Jagged2–Notch interaction

Kijima, Mika; Yamaguchi, Takeshi; Ishifune, Chieko; Maekawa, Yoichi; Koyanagi, Akemi; Yagita, Hideo; Chiba, Shigeru; Kishihara, Kenji; Shimada, Mitsuo; Yasutomo, Koji

doi:10.1073/pnas.0709919105

Cited by 59 publications

(55 citation statements)

References 26 publications

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“…Therefore, CTL differentiation is coregulated by several transcriptional pathways. Furthermore, we found that Notch signaling contributes to DCmediated NK cell activation, which enhanced the killing activity of NK cells (9). These studies suggest that Notch signaling is crucial for exerting cytotoxic responses in immune cells.…”

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confidence: 67%

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Notch2 Signaling Is Required for Potent Antitumor Immunity In Vivo

Sugimoto

Maekawa²,

Kitamura³

et al. 2010

The Journal of Immunology

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confidence: 67%

“…We have recently demonstrated that Notch signaling controls cytotoxic responses in both CTL and NK cells (8,9). These data suggest that Notch signaling is a crucial signaling pathway required for cytotoxic responses in immune cells.…”

Section: Discussionmentioning

confidence: 99%

Notch2 Signaling Is Required for Potent Antitumor Immunity In Vivo

Sugimoto

Maekawa²,

Kitamura³

et al. 2010

The Journal of Immunology

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“…Earlier studies carried out in murine CD8 + T lymphocytes and NK cells have demonstrated the importance of Notch signaling in regulating their effector functions (22,33). Notch signaling was shown to directly regulate granzyme B expression in CD8 + cytotoxic T lymphocytes (34).…”

Section: Discussionmentioning

confidence: 99%

“…Notch signaling also contributes to dendritic cell-mediated NK cell activation, which enhanced the killing activity of NK cells. Murine NK cells exhibit enhanced cytokine expression and cytotoxic function in response to signaling from tumor cells or dendritic cells transduced with Jag2 (33).…”

Section: Discussionmentioning

confidence: 99%

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Involvement of Notch in Activation and Effector Functions of γδ T cells

Gogoi

Dar

Chiplunkar

2014

The Journal of Immunology

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Notch signaling plays a pivotal role in cell fate decision and lineage commitment of lymphocytes. Although the role of Notch in CD4+ and CD8+ αβ T cells is well documented, there are no reports on how Notch signaling regulates effector functions of γδ T cells. γδ T cells are a minor fraction in the peripheral blood but are known to play a major role in defense against pathogens and tumors. In this study, we show that Notch receptors (mRNA and protein) are expressed in peripheral γδ T cells. Inhibition of Notch signaling by γ-secretase inhibitor inhibited the proliferation and IFN-γ secretion of γδ T cells in response to stimulation with phosphoantigens and anti-CD3 mAb. In the presence of γ-secretase inhibitor, the antitumor cytolytic ability of γδ T cells was inhibited with a decreased CD107a expression. Knockdown of Notch1 and Notch2 genes in γδ T cells using small interfering RNA inhibited their antitumor cytotoxic potential. Our study describes for the first time, to our knowledge, the role of Notch as an additional signal contributing to Ag-specific effector functions of γδ T cells.

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Notch signaling regulates the development of a novel type of Thy1‐expressing dendritic cell in the thymus

Ishifune¹,

Maekawa²,

Nishida³

et al. 2011

Eur J Immunol

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Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) required for T-cell activation and are classified into several subtypes by phenotypic and functional characteristics. However, it remains unclear if distinct transcription factors control the development of each DC subpopulation. In this report, we demonstrate that Notch signaling controls the development of a novel DC subtype that expresses Thy1 (Thy1 DC development in the thymus. Our data indicate that Notch signaling controls the development of a novel type of Thy1-expressing DC in the thymus that possibly controls negative selection, and indicates that there may be highly regulated, differential transcriptional control of DC development. Furthermore, our findings suggest that Notch signaling regulates T-cell development not only by intrinsically inducing T-cell lineage-specific gene programs, but also by regulating negative selection through Thy1 1 DCs.

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Dendritic cell-mediated NK cell activation is controlled by Jagged2–Notch interaction

Cited by 59 publications

References 26 publications

Notch2 Signaling Is Required for Potent Antitumor Immunity In Vivo

Notch2 Signaling Is Required for Potent Antitumor Immunity In Vivo

Involvement of Notch in Activation and Effector Functions of γδ T cells

Notch signaling regulates the development of a novel type of Thy1‐expressing dendritic cell in the thymus

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