Dendritic cell profiles in the inflamed colonic mucosa predict the responses to tumor necrosis factor alpha inhibitors in inflammatory bowel disease

Smrekar, Nataša; Drobne, David; Šmid, Lojze; Ferkolj, Ivan; Štabuc, Borut; Ihan, Alojz; Kopitar, Assist. Prof. Andreja Natasa

doi:10.2478/raon-2018-0045

Cited by 7 publications

(5 citation statements)

References 67 publications

(72 reference statements)

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“…Together, the reductions of Tnf messenger RNA levels and cDC proportions suggest that UVR has anti‐inflammatory effects in iBAT that are independent of UVR‐induced nitric oxide. Tumor necrosis factor activates cDCs, promoting their migration into inflamed tissue and draining lymph nodes, and subsequent capacity to secrete proinflammatory cytokines 24–26 . Importantly, DCs in adipose tissue may contribute toward obesity‐induced insulin resistance and inflammation 18 .…”

Section: Discussionmentioning

confidence: 99%

“…Tumor necrosis factor activates cDCs, promoting their migration into inflamed tissue and draining lymph nodes, and subsequent capacity to secrete proinflammatory cytokines. [24][25][26] Importantly, DCs in adipose tissue may contribute toward obesity-induced insulin resistance and inflammation. 18 Further experiments are needed to demonstrate whether there are functional links between reductions in tumor necrosis factor levels and cDCs in iBAT of mice exposed to UVR.…”

Section: Discussionmentioning

confidence: 99%

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Metabolic dysfunction induced by a high‐fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

Mincham

Panchal

Hart

et al. 2021

Immunol. Cell Biol.

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Brown adipose tissue (BAT) may be an important metabolic regulator of whole‐body glucose. While important roles have been ascribed to macrophages in regulating metabolic functions in BAT, little is known of the roles of other immune cells subsets, particularly dendritic cells (DCs). Eating a high‐fat diet may compromise the development of hematopoietic stem and progenitor cells (HSPCs)—which give rise to DCs—in bone marrow, with less known of its effects in BAT. We have previously demonstrated that ongoing exposure to low‐dose ultraviolet radiation (UVR) significantly reduced the ‘whitening’ effect of eating a high‐fat diet upon interscapular (i) BAT of mice. Here, we examined whether this observation may be linked to changes in the phenotype of HSPCs and myeloid‐derived immune cells in iBAT and bone marrow of mice using 12‐colour flow cytometry. Many HSPC subsets declined in both iBAT and bone marrow with increasing metabolic dysfunction. Conversely, with rising adiposity and metabolic dysfunction, conventional DCs (cDCs) increased in both of these tissues. When compared with a low‐fat diet, consumption of a high‐fat diet significantly reduced proportions of myeloid, common myeloid and megakaryocyte–erythrocyte progenitors in iBAT, and short‐term hematopoietic stem cells in bone marrow. In mice fed the high‐fat diet, exposure to low‐dose UVR significantly reduced proportions of cDCs in iBAT, independently of nitric oxide release from irradiated skin [blocked using the scavenger 2‐(4‐carboxyphenyl)‐4,4,5,5‐tetramethylimidazoline‐1‐oxyl‐3‐oxide potassium salt (cPTIO)], but did not significantly modify HSPC subsets in either tissue. Further studies are needed to determine whether changes in these cell populations contribute towards metabolic dysfunction .

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metabolic dysfunction induced by a high‐fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

Mincham

Panchal

Hart

et al. 2021

Immunol. Cell Biol.

View full text Add to dashboard Cite

show abstract

“…Together, the reductions of Tnf mRNA levels and cDC proportions suggest that UVR has anti-inflammatory effects in iBAT that are independent of UVRinduced nitric oxide. TNF activates cDCs, promoting their migration into inflamed tissue and draining lymph nodes, and subsequent capacity to secrete pro-inflammatory cytokines [24][25][26] . Importantly, DCs in adipose tissue may contribute towards obesity-induced insulin resistance and inflammation 18 .…”

Section: Discussionmentioning

confidence: 99%

Metabolic dysfunction induced by high-fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

Mincham¹,

Panchal²,

Hart³

et al. 2021

Preprint

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Brown adipose tissue (BAT) may be an important metabolic regulator of whole-body glucose. While important roles have been ascribed to macrophages in regulating metabolic functions in BAT, little known is known of the roles of other immune cells subsets, particularly dendritic cells (DCs). Eating a high fat diet may compromise the development of hematopoietic stem and progenitor cells (HSPC), which give rise to DCs, in bone marrow, with less known of its effects in BAT. We have previously demonstrated that ongoing exposure to low-dose ultraviolet radiation (UVR) significantly reduced the whitening effect of eating a high-fat diet upon interscapular (i)BAT of mice. Here, we examined whether this observation may be linked to changes in the phenotype of HSPC and myeloid-derived immune cells in iBAT and bone marrow of mice using 12-colour flow cytometry. Many HSPC subsets declined in both iBAT and bone marrow with increasing metabolic dysfunction. Conversely, with rising adiposity and metabolic dysfunction, conventional (c)DCs increased in both of these tissues. When compared to low-fat diet, consumption of high-fat diet significantly reduced proportions of myeloid, common myeloid and megakaryocyte-erythrocyte progenitors in iBAT, and short-term hematopoietic stem cells in bone marrow. In mice fed a high-fat diet, exposure to low-dose UVR significantly reduced proportions of cDCs in iBAT, independently of nitric oxide release from irradiated skin (blocked using the scavenger, cPTIO), but did not significantly modify HSPC subsets in either tissue. Further studies are needed to determine whether changes in these cell populations contribute towards metabolic dysfunction.

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“…Specifically, betalactam antibiotics have demonstrated to alter DC maturation in allergic patients via MAPK and NF-kB signaling pathways ( 167 ). IBD is also promoted by DC migration and maturation, so the targeting of DCs with betalactam antibiotics may improve clinical outcomes in the disease ( 115 , 116 , 168 ). Probiotics have also been successfully proposed to modulate the gut microbiota in IBD ( 169 ).…”

Section: Therapeutic Approaches To Inhibit Dcs In Ibdmentioning

confidence: 99%

Dendritic cells: the yin and yang in disease progression

Jiménez-Cortegana,

Palomares,

Alba

et al. 2024

Front. Immunol.

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Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. DCs have been historically considered as the most effective and potent cell population to capture, process and present antigens to activate naïve T cells and originate favorable immune responses in many diseases, such as cancer. However, in the last decades, it has been observed that DCs not only promote beneficial responses, but also drive the initiation and progression of some pathologies, including inflammatory bowel disease (IBD). In line with those notions, different therapeutic approaches have been tested to enhance or impair the concentration and role of the different DC subsets. The blockade of inhibitory pathways to promote DCs or DC-based vaccines have been successfully assessed in cancer, whereas the targeting of DCs to inhibit their functionality has proved to be favorable in IBD. In this review, we (a) described the general role of DCs, (b) explained the DC subsets and their role in immunogenicity, (c) analyzed the role of DCs in cancer and therapeutic approaches to promote immunogenic DCs and (d) analyzed the role of DCs in IBD and therapeutic approaches to reduced DC-induced inflammation. Therefore, we aimed to highlight the “yin-yang” role of DCs to improve the understand of this type of cells in disease progression.

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Dendritic cell profiles in the inflamed colonic mucosa predict the responses to tumor necrosis factor alpha inhibitors in inflammatory bowel disease

Cited by 7 publications

References 67 publications

Metabolic dysfunction induced by a high‐fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

Metabolic dysfunction induced by a high‐fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

Metabolic dysfunction induced by high-fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

Dendritic cells: the yin and yang in disease progression

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