Dendritic cell tracking and modulation

Abstract

In situ metabolic labelling and targeted modulation of dendritic cells has been achieved using a hydrogel system in combination with covalent capture of antigens and adjuvants, facilitating improved tumour-specific immune response.

Generation of αGal-enhanced bifunctional tumor vaccine

“…Dendritic cells (DCs) are specialized antigen presenting cells, which can effectively induce the activity of T cells. Therefore, fusion of DCs with tumor cells can activate cytotoxic T lymphocytes (CTLs) to trigger effective tumor-specific immune response 6 , 7 , 8 . The high efficiency and specificity of this CTL-mediated cytotoxicity demonstrates the possibility of developing an effective cancer vaccine 9 , 10 , 11 .…”