2010
DOI: 10.1016/j.jaci.2009.11.019
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Dendritic cells: Bridging innate and adaptive immunity in atopic dermatitis

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Cited by 88 publications
(73 citation statements)
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References 110 publications
(167 reference statements)
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“…These cells have increased expression of highaffinity receptor for IgE (FcεRI), which captures allergens for antigen processing and presentation to Th2 cells (38,39). TLRactivated DC determines the type of T-cell response: activation of TLR4 on DC by microbial pathogens induces Th1 response, whereas activation of TLR4 on DC in the presence of TSLP or TGF-β and IL-6 promotes Th2 or Th17 response, respectively (40). Langerhans cells isolated from healthy human skin …”
Section: Adaptive Immunity: Perpetrator Of Persistent and Chronic Infmentioning
confidence: 99%
See 1 more Smart Citation
“…These cells have increased expression of highaffinity receptor for IgE (FcεRI), which captures allergens for antigen processing and presentation to Th2 cells (38,39). TLRactivated DC determines the type of T-cell response: activation of TLR4 on DC by microbial pathogens induces Th1 response, whereas activation of TLR4 on DC in the presence of TSLP or TGF-β and IL-6 promotes Th2 or Th17 response, respectively (40). Langerhans cells isolated from healthy human skin …”
Section: Adaptive Immunity: Perpetrator Of Persistent and Chronic Infmentioning
confidence: 99%
“…Cutaneous and systemic Th2 responses may amplify and maintain AD inflammation in a positive feedback mechanism (45). The absence of T-regulatory cells, and therefore a lack of suppression of cutaneous inflammation, may further contribute to the chronicity of AD (40).…”
Section: Pathogenesis Of Atopic Dermatitismentioning
confidence: 99%
“…DCs are eliminated by apoptosis after their interaction with T cells [2,6] . DCs play a critical role by bridging the innate and adaptive immune responses [5,32] . The innate immune response is the first line of defense against foreign pathogens and tissue injuries or malignancies.…”
Section: Biology Of Dcsmentioning
confidence: 99%
“…Further investigation revealed DCs were also a link between the innate and adaptive immune systems [2,3] . DCs that were activated via endogenous or exogenous antigens progressed from immature DCs to mature DCs, which initiated the release of cytokines that activated the T cell/B cell immune responses [2,[4][5][6] . DCs have now been confirmed to be involved in many different disease conditions, such as rheumatoid arthritis, pulmonary allergic disease, rhinitis and other autoimmune diseases [7][8][9] .…”
Section: Introductionmentioning
confidence: 99%
“…Concerning allergens, it is conceivable that their facilitated access favours the sensitization process, especially for house dust mites, the protease activity of their major allergen being a further enhancing factor (13). Once entered, allergens are captured by dendritic cells (14) that activate an initially local Th2 but a later Th1 response along with a systemic Th2 response inducing the Ig isotype switching to IgE synthesis and the involvement of eosinophils (2). In this kind of response an important factor seems to be thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine expressed by barrier epithelial cells able to activate myeloid-derived dendritic cells, macrophages and mast cells (15).…”
mentioning
confidence: 99%