Dendritic Cells: Immune Response in Infectious Diseases and Autoimmunity

Sesti-Costa, Renata; Moraes‐Vieira, Pedro M.; Cervantes-Barragán, Luisa

doi:10.1155/2020/2948525

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…A key mechanism that protects tissue against prolonged immune reactions or immune reactions to self-antigens, is the active suppression of effector T cell functions by regulatory T cells (Treg) ( Figure 1 ) [ 45 ]. In conditions associated with tissue damage or hypoxia, there can be a non-resolving inflammation and/or auto-immune reactions, by redirecting the immune reaction towards the dominance of the Th1/Th17 effector pathway ( Figure 1 ) [ 46 ].…”

Section: Leukocyte Counts and Ratios As Markers Of Inflammation In Cardiovascular Diseasementioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio as a Cardiovascular Risk Marker May Be Less Efficient in Women Than in Men

et al. 2021

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Cardiovascular disease (CVD) is the leading cause of death in women, although traditionally, it has been considered as a male dominated disease. Chronic inflammation plays a crucial role in the development of insulin resistance, diabetes type 2 and CVD. Since studies on women were scarce, in order to improve diagnosis and treatment of CVD, there is a need to improve understanding of the role of inflammation in the development of CVD in women. The neutrophil-to-lymphocyte ratio (NLR) is an inexpensive and widely available marker of inflammation, and has been studied in cardio-metabolic disorders. There is a paucity of data on sex specific differences in the lifetime course of NLR. Men and women differ to each other in sex hormones and characteristics of immune reaction and the expression of CVD. These factors can determine NLR values and their variations along the life course. In particular, menopause in women is a period associated with profound physiological and hormonal changes, and is coincidental with aging. An emergence of CV risk factors with aging, and age-related changes in the immune system, are factors that are associated with an increase in prevalence of CVD in both sexes. The aim of this review is to comprehend the available evidence on this issue, and to discuss sex specific differences in the lifetime course of NLR in the light of immune and inflammation mechanisms.

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Section: Leukocyte Counts and Ratios As Markers Of Inflammation In Cardiovascular Diseasementioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio as a Cardiovascular Risk Marker May Be Less Efficient in Women Than in Men

et al. 2021

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“…Finally, DCs present captured antigens to antigen-specific T and B cells to induce adaptive immune responses. [19][20][21] In the steady state, they maintain peripheral immune tolerance, possibly via initiating anergy of T cells or T regulatory cells (Tregs) through the presentation of self-antigen. [22][23][24] Commonly, DCs are grouped into several DC subsets according to the differences in morphological, phenotypic and functional specificity both in humans and mice.…”

Section: Roles Of Dendritic Cells In Immunity and Hbv Controlmentioning

confidence: 99%

“…Here, they mature gradually with upregulation of CD80 and CD86, adhesins, and major histocompatibility complex (MHC) class I and II as well under appropriate signals. Finally, DCs present captured antigens to antigen‐specific T and B cells to induce adaptive immune responses 19–21 . In the steady state, they maintain peripheral immune tolerance, possibly via initiating anergy of T cells or T regulatory cells (Tregs) through the presentation of self‐antigen 22–24 .…”

Section: Introductionmentioning

confidence: 99%

Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection

2023

Clinical and Translational Dis

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Dendritic cells (DCs) play a crucial role in initiating the adaptive immune response that could determine the outcome of Hepatitis B virus infection. The efficacy of DC-based immunotherapy may be improved via several strategies including treatment of interleukin-12, pDC-derived interferon (IFN)-α, monophosphoryl lipid A and IFN-γ, uric acid as well as blockade of B7 homolog 1. Besides, DCs with an engineered expression of HBV S-ecdCD40L, or pulsed with M1:HBcAg conjugates or transfection of recombinant plasmid pEGFP-N1-C (472-507)-ecdCD40L also showed improved efficacy.

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“…The sophisticated ontogeny of DCs enables them to maintain tolerance in the presence of foreign and self-antigens or to initiate an inflammatory response ( 4 – 6 ). Striking the right balance to antigen response puts DCs in a critical pathway for disease management ( 7 , 8 ). An insufficient immune response to an antigen can suppress downstream cell differentiation leading to an increased risk of infection and malignancy ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery

et al. 2023

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Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique ability to mediate inflammatory responses of the immune system. Given the critical role of DCs in shaping immunity, they present an attractive avenue as a therapeutic target to program the immune system and reverse immune disease disorders. To ensure appropriate immune response, DCs utilize intricate and complex molecular and cellular interactions that converge into a seamless phenotype. Computational models open novel frontiers in research by integrating large-scale interaction to interrogate the influence of complex biological behavior across scales. The ability to model large biological networks will likely pave the way to understanding any complex system in more approachable ways. We developed a logical and predictive model of DC function that integrates the heterogeneity of DCs population, APC function, and cell-cell interaction, spanning molecular to population levels. Our logical model consists of 281 components that connect environmental stimuli with various layers of the cell compartments, including the plasma membrane, cytoplasm, and nucleus to represent the dynamic processes within and outside the DC, such as signaling pathways and cell-cell interactions. We also provided three sample use cases to apply the model in the context of studying cell dynamics and disease environments. First, we characterized the DC response to Sars-CoV-2 and influenza co-infection by in-silico experiments and analyzed the activity level of 107 molecules that play a role in this co-infection. The second example presents simulations to predict the crosstalk between DCs and T cells in a cancer microenvironment. Finally, for the third example, we used the Kyoto Encyclopedia of Genes and Genomes enrichment analysis against the model’s components to identify 45 diseases and 24 molecular pathways that the DC model can address. This study presents a resource to decode the complex dynamics underlying DC-derived APC communication and provides a platform for researchers to perform in-silico experiments on human DC for vaccine design, drug discovery, and immunotherapies.

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Dendritic Cells: Immune Response in Infectious Diseases and Autoimmunity

Cited by 9 publications

References 10 publications

Neutrophil-to-Lymphocyte Ratio as a Cardiovascular Risk Marker May Be Less Efficient in Women Than in Men

Neutrophil-to-Lymphocyte Ratio as a Cardiovascular Risk Marker May Be Less Efficient in Women Than in Men

Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection

A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery

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