2008
DOI: 10.2217/17460913.3.3.279
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Dendritic Cells in Plasmodium Infection

Abstract: Infection with Plasmodium parasites (malaria) contributes greatly to morbidity and mortality in affected areas. Interaction of the protozoan with the immune system has a critical role in the pathogenesis of the disease, but may also hold a key to containing parasite numbers through specific immune responses, which vaccine development aims to harness. A central player in the generation of such immune responses is the dendritic cell. However, Plasmodium parasites appear to have profound activating and suppressin… Show more

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Cited by 9 publications
(6 citation statements)
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“…In addition, higher numbers of circulating BDCA-3 + mDCs have been detected in the blood of severely infected children combined with reduced immunostimulatory ability. This indicates that malaria may impair mDC functionality and suggests that the BDCA-3 + DC subset may play a crucial role in the immune response against the parasite in humans [16], [17].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, higher numbers of circulating BDCA-3 + mDCs have been detected in the blood of severely infected children combined with reduced immunostimulatory ability. This indicates that malaria may impair mDC functionality and suggests that the BDCA-3 + DC subset may play a crucial role in the immune response against the parasite in humans [16], [17].…”
Section: Introductionmentioning
confidence: 99%
“…The few studies directly investigating the impact of malaria on human DC function have yielded conflicting results. A recent balanced review attempts to resolves these apparent contradictions concluding that disparate findings could be explained by low‐dose immune induction vs. high‐dose immune suppression (89). The authors suggest the dose‐dependent DC response sequentially varies during the course of an individual infection from early, low‐dose responsiveness to late, high‐dose nonresponsiveness.…”
Section: A Pivotal Role For Innate Immunitymentioning
confidence: 99%
“…The activated DC and signals induced by cytokines together regulate Th1/Th2 development (9). In malaria, DC are the major early responders that produce pro-inflammatory cytokines, leading to NK and T cell activation and IFN-γ production (10)(11)(12). IFN-γ contributes to parasitemia control by priming phagocytes for clearance of parasites (13).…”
Section: Introductionmentioning
confidence: 99%