Dendritic cells in rejection and acceptance of solid organ allografts

Aj, Demetris; Murase, Noriko; Jj, Fung; Starzl, TE

doi:10.1016/b978-012455851-9/50071-7

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2007

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“…They are crucial instigators of posttransplantation rejection, migrating as “passenger leukocytes” from a donor allograft into recipient lymph nodes where they stimulate naïve T cells to attack foreign tissue 3 . There is also some evidence that recipient DC present alloantigen to host T cells, but the relative contribution of this process to acute rejection remains undefined 4 . Classic investigations have mostly tracked the migration of donor leukocytes (DL) (and not specifically donor DC) during the acute phase of rejection 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Postallograft Donor and Recipient Dendritic Cell Trafficking in the Rat Larynx

et al. 2007

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The paradigm of donor DC efflux and recipient DC influx has been confirmed in a rat laryngeal transplant model, and the allograft-specific timing of these events has been elucidated. Similarities in total DC migration between allografts and isografts suggest that this phenomenon may not be driven entirely by major histocompatibility mismatch. Further understanding of trafficking may help with the goal of manipulating DC to induce allograft tolerance in the absence of generalized immunosuppression.

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Section: Introductionmentioning

confidence: 99%