Dendritic Cells in the Pathogenesis of Sarcoidosis

Genome-wide association analysis reveals 12q13.3–q14.1 as new risk locus for sarcoidosis

“…In addition, it has recently been shown that OS9 interacts with the cytoplasmic tail of the dendritic cell-specific transmembrane protein during toll-like receptor-induced maturation of dendritic cells suggesting a role for OS9 in myeloid differentiation and cell fusion [52]. Dendritic cells have been discussed as important mediators of sarcoidosis immunology [53] and have been widely investigated with regards to various aspects of sarcoidosis [53][54][55][56].…”

Dendritic cell recruitment and activation in autoimmunity

“…During EAE, the T-DC interaction in the brain requires CCR4, which regulates GM-CSF and IL-23 production by DCs [224], thus promoting Th1 and Th17 effector functions [225,226]. Several observations demonstrate that sarcoidosis can be considered an autoimmune disease promoted by self-antigen priming of Th1 effectors by cDCs [227]. Bronchoalveolar fluid from sarcoidosis patients was enriched with cDCs showing immature phenotype and producing high levels of IL-12 and IL-18 responsible for Th1-mediated pathogenesis [228,229].…”

“…and NK cells at sites of epithelial damage, raising the question whether pDCs may cooperate with professional cytotoxic cells in inducing keratinocyte killing [227,228] (Fig. 2).…”

Lung Diseases - Selected State of the Art Reviews

“…These granulomas are compact, organized collections of macrophages and epithelioid cells, surrounded by and infiltrated with T lymphocytes, but the pathological processes that result in granulomatous inflammation are largely unknown. The accumulation in the lung of apparently oligoclonal IFN-producing T helper cells in sarcoidosis indicated an antigen-driven Th1 response (Rosen 2007;Zaba et al 2010). Also because IL-17A has been implicated in the formation of a mycobacterial infection-induced granuloma in the lung (Curtis and Way …”