Dendritic Cells Promote the Spread of Human T-Cell Leukemia Virus Type 1 via Bidirectional Interactions with CD4+ T Cells

Shimauchi, Takatoshi; Caucheteux, Stephan M.; Finsterbusch, Katja; Turpin, Jocelyn; Blanchet, Fabien P.; Ladell, Kristin; Triantafilou, Kathy; Czubala, Magdalena; Tatsuno, Kazuki; Easter, T; Ahmed, Zahra; Bayliss, Rebecca; Hakobyan, Svetlana; Price, David A.; Tokura, Y.; Piguet, Vincent

doi:10.1016/j.jid.2018.06.188

Cited by 10 publications

(9 citation statements)

References 38 publications

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“…However, it is worth noting that, in some case, i.e. when HTLV-1 accumulated at MDDCs surface without internalization and thus without productive infection, viral transfer and productive T-cells infection was efficient [58].…”

Section: Infection Of Myeloid Cells By Htlv-1mentioning

confidence: 99%

HTLV-1 infection of myeloid cells: from transmission to immune alterations

Rocamonde¹,

Carcone²,

Mahieux³

et al. 2019

Retrovirology

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Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), was the first human retrovirus to be discovered. T-cells, which represent the main reservoir for HTLV-1, have been the main focus of studies aimed at understanding viral transmission and disease progression. However, other cell types such as myeloid cells are also target of HTLV-1 infection and display functional alterations as a consequence. In this work, we review the current investigations that shed light on infection, transmission and functional alterations subsequent to HTLV-1 infection of the different myeloid cells types, and we highlight the lack of knowledge in this regard.

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Section: Infection Of Myeloid Cells By Htlv-1mentioning

confidence: 99%

HTLV-1 infection of myeloid cells: from transmission to immune alterations

Rocamonde¹,

Carcone²,

Mahieux³

et al. 2019

Retrovirology

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“…As for HSV-1, SFVs use HS as an attachment factor [ 30 , 31 ]. Among retroviruses, membrane protrusions of murine leukemia viruses (MLV), HTLV-1 and HIV-1 have been described: some are open ended, allowing the transfer of viral material without exposure to the extracellular surface while others are closed ended and Env-receptor interaction is required for cell-to-cell infection [ 74 – 78 ]. In addition, viruses can move along such protrusions while being fully exposed to neutralizing antibodies.…”

Section: Discussionmentioning

confidence: 99%

Plasma antibodies from humans infected with zoonotic simian foamy virus do not inhibit cell-to-cell transmission of the virus despite binding to the surface of infected cells

et al. 2022

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Zoonotic simian foamy viruses (SFV) establish lifelong infection in their human hosts. Despite repeated transmission of SFV from nonhuman primates to humans, neither transmission between human hosts nor severe clinical manifestations have been reported. We aim to study the immune responses elicited by chronic infection with this retrovirus and previously reported that SFV-infected individuals generate potent neutralizing antibodies that block cell infection by viral particles. Here, we assessed whether human plasma antibodies block SFV cell-to-cell transmission and present the first description of cell-to-cell spreading of zoonotic gorilla SFV. We set-up a microtitration assay to quantify the ability of plasma samples from 20 Central African individuals infected with gorilla SFV and 9 uninfected controls to block cell-associated transmission of zoonotic gorilla SFV strains. We used flow-based cell cytometry and fluorescence microscopy to study envelope protein (Env) localization and the capacity of plasma antibodies to bind to infected cells. We visualized the cell-to-cell spread of SFV by real-time live imaging of a GFP-expressing prototype foamy virus (CI-PFV) strain. None of the samples neutralized cell-associated SFV infection, despite the inhibition of cell-free virus. We detected gorilla SFV Env in the perinuclear region, cytoplasmic vesicles and at the cell surface. We found that plasma antibodies bind to Env located at the surface of cells infected with primary gorilla SFV strains. Extracellular labeling of SFV proteins by human plasma samples showed patchy staining at the base of the cell and dense continuous staining at the cell apex, as well as staining in the intercellular connections that formed when previously connected cells separated from each other. In conclusion, SFV-specific antibodies from infected humans do not block cell-to-cell transmission, at least in vitro, despite their capacity to bind to the surface of infected cells. Trial registration: Clinical trial registration: www.clinicaltrials.gov, https://clinicaltrials.gov/ct2/show/NCT03225794/.

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“…However, Tanaka et al found that the cellular susceptibility to HTLV-1 infection did not correlate with the expression of GLUT1, HS, or NRP-1 alone [56]. Cell-to-cell transmission of HTLV-1 can occur frequently after interactions between DCs and T cells, as well as between T cells [46,57]. Because DCs, monocytes, macrophages, and B cells express these receptors, they can also be infected with each other in individuals with HTLV-1 [44,58].…”

Section: Cell-to-cell Transmissionmentioning

confidence: 99%

Mother-to-Child Transmission of Human T-Cell Leukemia Virus Type 1: Mechanisms and Nutritional Strategies for Prevention

Itabashi

Miyazawa

2021

Cancers

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Approximately 95% of mother-to-child transmission (MTCT) of human T-cell leukemia virus type-1 (HTLV-1) is derived from prolonged breastfeeding, which is a major cause of adult T-cell leukemia (ATL). Exclusive formula feeding (ExFF) is therefore generally used to prevent MTCT. A recent cohort study revealed that 55% of pregnant carriers chose short-term breastfeeding for ≤ 3 months in Japan. Our meta-analysis showed that there was no significant increase in the risk of MTCT when breastfeeding was carried out for ≤ 3 months compared with ExFF (pooled relative risk (RR), 0.72; 95% confidence interval (CI), 0.30–1.77), but there was an almost threefold increase in risk when breastfeeding was carried out for up to 6 months (pooled RR, 2.91; 95% CI, 1.69–5.03). Thus, short-term breastfeeding for ≤ 3 months may be useful in preventing MTCT. Breastmilk is the best nutritional source for infants, and any approach to minimizing MTCT by avoiding or limiting breastfeeding must be balanced against the impact on the child’s health and mother–child bonding. To minimize the need for nutritional interventions, it is necessary to identify factors that predispose children born to carrier mothers to MTCT and thereby predict MTCT development with a high degree of accuracy.

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Dendritic Cells Promote the Spread of Human T-Cell Leukemia Virus Type 1 via Bidirectional Interactions with CD4+ T Cells

Cited by 10 publications

References 38 publications

HTLV-1 infection of myeloid cells: from transmission to immune alterations

HTLV-1 infection of myeloid cells: from transmission to immune alterations

Plasma antibodies from humans infected with zoonotic simian foamy virus do not inhibit cell-to-cell transmission of the virus despite binding to the surface of infected cells

Mother-to-Child Transmission of Human T-Cell Leukemia Virus Type 1: Mechanisms and Nutritional Strategies for Prevention

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