Dendritic Mesoporous Nanoparticles: Structure, Synthesis and Properties

Xu, Chun; Lei, Chang; Wang, Yue; Yu, Chengzhong

doi:10.1002/anie.202112752

Cited by 82 publications

(60 citation statements)

References 130 publications

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“…Upon removal of the volatile organic solvent, an optically transparent aqueous colloidal solution has been formed, confirming the success of the CTAB assisted NCs stabilization in water, with limited NC aggregation (Step II, Figure 2 ). The MSS growth, onto the CTAB-stabilized Cu 2−x S NCs, has been carried out following a microemulsion approach [ 54 ] using ethyl acetate as an organic solvent, that is added in a volume ratio with the aqueous solution of nearly 1:15. TEOS, the silica precursor, is first dissolved in the ethyl acetate organic phase, then gradually hydrolyzed at the oil–water interface to allow surfactant–silicate assembly in the water phase and further condenses forming the silica network.…”

Section: Resultsmentioning

confidence: 99%

NIR-Absorbing Mesoporous Silica-Coated Copper Sulphide Nanostructures for Light-to-Thermal Energy Conversion

et al. 2022

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Plasmonic nanostructures, featuring near infrared (NIR)-absorption, are rising as efficient nanosystems for in vitro photothermal (PT) studies and in vivo PT treatment of cancer diseases. Among the different materials, new plasmonic nanostructures based on Cu2−xS nanocrystals (NCs) are emerging as valuable alternatives to Au nanorods, nanostars and nanoshells, largely exploited as NIR absorbing nanoheaters. Even though Cu2−xS plasmonic properties are not linked to geometry, the role played by their size, shape and surface chemistry is expected to be fundamental for an efficient PT process. Here, Cu2−xS NCs coated with a hydrophilic mesoporous silica shell (MSS) are synthesized by solution-phase strategies, tuning the core geometry, MSS thickness and texture. Besides their loading capability, the silica shell has been widely reported to provide a more robust plasmonic core protection than organic molecular/polymeric coatings, and improved heat flow from the NC to the environment due to a reduced interfacial thermal resistance and direct electron–phonon coupling through the interface. Systematic structural and morphological analysis of the core-shell nanoparticles and an in-depth thermoplasmonic characterization by using a pump beam 808 nm laser, are carried out. The results suggest that large triangular nanoplates (NPLs) coated by a few tens of nanometers thick MSS, show good photostability under laser light irradiation and provide a temperature increase above 38 °C and a 20% PT efficiency upon short irradiation time (60 s) at 6 W/cm2 power density.

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Section: Resultsmentioning

confidence: 99%

NIR-Absorbing Mesoporous Silica-Coated Copper Sulphide Nanostructures for Light-to-Thermal Energy Conversion

et al. 2022

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“…The DMSN was chosen as the carrier for the delivery of levobupivacaine and PFP. 25 , 30 , 31 The hollow interior structure of DMSN endows these nanocarriers with high loading capacity. The carrying PFP could achieve a fast “liquid-to-gas” transformation under biomedical ultrasound irradiation, and the levobupivacaine could induce local anesthetics without apparent side effects.…”

Section: Resultsmentioning

confidence: 99%

Moderate-Intensity Ultrasound-Triggered On-Demand Analgesia Nanoplatforms for Postoperative Pain Management

Song¹,

Luan²,

Zhang³

et al. 2022

IJN

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Introduction The restricted duration is a fundamental drawback of traditional local anesthetics during postoperative pain from a single injection. Therefore, an injectable local anesthetic that produces repeatable on-demand nerve blocks would be ideal. Methods We offer ultrasound-triggered on-demand analgesia consisting of dendritic mesoporous silica nanoparticles (DMSN) carried with ultrasound-sensitive perfluoropentane (PFP) and levobupivacaine (DMSN-bupi-PFP) to achieve repeatable and customizable on-demand local anesthetics. Results The vaporization of liquid PFP was triggered by ultrasound irradiation to produce a gas environment. Subsequently, the enhanced cavitation effect could improve the release of levobupivacaine to achieve pain relief under a moderate-intensity ultrasound irradiation. DMSN-bupi-PFP demonstrated a controlled-release pattern and showed a reinforced ultrasonic sensitivity compared to levobupivacaine loaded DMSN (DMSN-bupi). The sustained release of levobupivacaine produced continuous analgesia of more than 9 hours in a model of incision pain, approximately 3 times longer than a single free levobupivacaine injection (3 hours). The external ultrasound irradiation can trigger the release of levobupivacaine repeatedly, resulting in on-demand analgesia. In addition, DMSN-bupi-PFP nanoplatforms for ultrasound-enabled analgesia showed low neurotoxicity and good biocompatibility in vitro and in vivo. Conclusion This DMSN-bupi-PFP nanoplatform can be used in pain management by providing long-lasting and on-demand pain alleviation with the help of moderate-intensity ultrasound.

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“…Porous nanomaterials (PNMs) with porous structures and high surface/pore volume have been widely used in the biomedical field [ 17 , 18 ], especially as drug carriers. PNMs possess some intrinsic advantages such as high loading capacity of biomolecules, tunable structures, abundant surface modification, and controllable release behavior of loaded molecules such as immunomodulators [ 11 , 19 , 20 ]. PNMs can enhance cancer immunotherapy through several pathways including delivering antigens and stimulating molecules into target cells/tissues, modulating immune dysfunction in the tumor microenvironment, and promoting ACT therapy efficacy (Fig.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in porous nanomaterials-based drug delivery systems for cancer immunotherapy

Huo

Wang

et al. 2022

J Nanobiotechnol

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Cancer immunotherapy is a novel therapeutic regimen because of the specificity and durability of immune modulations to treat cancers. Current cancer immunotherapy is limited by some barriers such as poor response rate, low tumor specificity and systemic toxicities. Porous nanomaterials (PNMs) possess high loading capacity and tunable porosity, receiving intense attention in cancer immunotherapy. Recently, novel PNMs based drug delivery systems have been employed in antitumor immunotherapy to enhance tissue or organ targeting and reduce immune-related adverse events. Herein, we summarize the recent progress of PNMs including inorganic, organic, and organic–inorganic hybrid ones for cancer immunotherapy. The design of PNMs and their performance in cancer immunotherapy are discussed in detail, with a focus on how those designs can address the challenges in current conventional immunotherapy. Lastly, we present future directions of PNMs for cancer immunotherapy including the challenges and research gaps, providing new insights about the design of PNMs for efficient cancer immunotherapy with better performance as powerful weapons against tumors. Finally, we discussed the relevant challenges that urgently need to be addressed in clinical practice, coupled with corresponding solutions to these problems.

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Dendritic Mesoporous Nanoparticles: Structure, Synthesis and Properties

Cited by 82 publications

References 130 publications

NIR-Absorbing Mesoporous Silica-Coated Copper Sulphide Nanostructures for Light-to-Thermal Energy Conversion

NIR-Absorbing Mesoporous Silica-Coated Copper Sulphide Nanostructures for Light-to-Thermal Energy Conversion

Moderate-Intensity Ultrasound-Triggered On-Demand Analgesia Nanoplatforms for Postoperative Pain Management

Recent advances in porous nanomaterials-based drug delivery systems for cancer immunotherapy

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