Sonodynamic therapy (SDT), which involves the activation
of sonosensitizers
to generate cytotoxic reactive oxygen species under ultrasound irradiation,
is a promising noninvasive modality for cancer treatment. However,
the clinical translational application of SDT is impeded by the lack
of efficient sonosensitizers, the inefficient accumulation of sonosensitizers
at tumor sites, and the complicated immunosuppressive tumor microenvironment.
Herein, we developed a facilely synthesized multifunctional porous
organic polymer nanosonosensitizer (mHM@HMME) for enhanced SDT. Specifically,
mHM@HMME nanosonosensitizers were prepared by incorporating chemotherapeutic
mitoxantrone into the one-step synthesis process of disulfide bond
containing porous organic polymers, followed by loading with organic
sonosensitizer (HMME) and camouflaging with a cancer cell membrane.
Due to the cancer cell membrane camouflage, this multifunctional mHM@HMME
nanosonosensitizer showed prolonged blood circulation and tumor targeting
aggregation. Under ultrasound irradiation, the mHM@HMME nanosonosensitizer
exhibited a satisfactory SDT performance both in vitro and in vivo.
Moreover, the potent SDT combined with glutathione-responsive drug
release in tumor cells induced robust immunogenic cell death to enhance
the antitumor effect of SDT in turn. Overall, this facilely synthesized
multifunctional mHM@HMME nanosonosensitizer shows great potential
application in enhanced SDT.