Dendrobium mixture ameliorates hepatic injury induced by insulin resistance in vitro and in vivo through the downregulation of AGE/RAGE/Akt signaling pathway

Zhuang, Shuting; Zhou, Xian; Yang, Xiaowen; Chang, Dennis; Chen, Tao; Sun, Yibin; Wang, Chenxiang; Zhang, Chutian; Jiang, Jichao; Chen, Yong; Lin, Xiaohui; Wang, Xiaoning; Yu, Wenzhen; Lin, Xinjun; He, Caigu; Zheng, Yanfang; Zhang, Jieping; Shi, Hong

doi:10.1016/j.heliyon.2023.e22007

Cited by 1 publication

(2 citation statements)

References 34 publications

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“…p53 is well known for its tumor suppressor role, which is associated with an increased risk of DM, obesity, metabolism, and inflammation [87,88]. YTHDF2 and m6A modification could regulate the process of autophagy [89], which may be connected to the development of DM and MAFLD [90]. Interestingly, hepatic gluconeogenesis in the liver might be regulated via the PI3K/AKT signaling pathway [90].…”

Section: Relationship Between Ythdf2 and Diabetes Mellitus Obesity Or...mentioning

confidence: 99%

“…YTHDF2 and m6A modification could regulate the process of autophagy [89], which may be connected to the development of DM and MAFLD [90]. Interestingly, hepatic gluconeogenesis in the liver might be regulated via the PI3K/AKT signaling pathway [90]. Downregulation of YTHDF2 can enhance the expression of SOCS2, which may negatively regulate the cell proliferation pathway of JAK/STAT signaling [91].…”

Section: Relationship Between Ythdf2 and Diabetes Mellitus Obesity Or...mentioning

confidence: 99%

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Circular RNAs, Noncoding RNAs, and N6-methyladenosine Involved in the Development of MAFLD

Nakashima,

Suga,

Ikeda

et al. 2024

ncRNA

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Noncoding RNAs (ncRNAs), including circular RNAs (circRNAs) and N6-methyladenosine (m6A), have been shown to play a critical role in the development of various diseases including obesity and metabolic disorder-associated fatty liver disease (MAFLD). Obesity is a chronic disease caused by excessive fat accumulation in the body, which has recently become more prevalent and is the foremost risk factor for MAFLD. Causes of obesity may involve the interaction of genetic, behavioral, and social factors. m6A RNA methylation might add a novel inspiration for understanding the development of obesity and MAFLD with post-transcriptional regulation of gene expression. In particular, circRNAs, microRNAs (miRNAs), and m6A might be implicated in the progression of MAFLD. Interestingly, m6A modification can modulate the translation, degradation, and other functions of ncRNAs. miRNAs/circRNAs can also modulate m6A modifications by affecting writers, erasers, and readers. In turn, ncRNAs could modulate the expression of m6A regulators in different ways. However, there is limited evidence on how these ncRNAs and m6A interact to affect the promotion of liver diseases. It seems that m6A can occur in DNA, RNA, and proteins that may be associated with several biological properties. This study provides a mechanistic understanding of the association of m6A modification and ncRNAs with liver diseases, especially for MAFLD. Comprehension of the association between m6A modification and ncRNAs may contribute to the development of treatment tactics for MAFLD.

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Section: Relationship Between Ythdf2 and Diabetes Mellitus Obesity Or...mentioning

confidence: 99%

Section: Relationship Between Ythdf2 and Diabetes Mellitus Obesity Or...mentioning

confidence: 99%

Circular RNAs, Noncoding RNAs, and N6-methyladenosine Involved in the Development of MAFLD

Nakashima,

Suga,

Ikeda

et al. 2024

ncRNA

View full text Add to dashboard Cite

show abstract

Dendrobium mixture ameliorates hepatic injury induced by insulin resistance in vitro and in vivo through the downregulation of AGE/RAGE/Akt signaling pathway

Cited by 1 publication

References 34 publications

Circular RNAs, Noncoding RNAs, and N6-methyladenosine Involved in the Development of MAFLD

Circular RNAs, Noncoding RNAs, and N6-methyladenosine Involved in the Development of MAFLD

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