Dendrobium officinale Kimura et Migo attenuates diabetic cardiomyopathy through inhibiting oxidative stress, inflammation and fibrosis in streptozotocin-induced mice

Zhang, Zhihao; Zhang, Duoduo; Dou, Mengmeng; Li, Zhubo; Zhang, Jie; Zhao, Xiaoyan

doi:10.1016/j.biopha.2016.10.074

Cited by 63 publications

(41 citation statements)

References 29 publications

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“…In the present study, our results showed that, compared with normal control rats, several weeks of hyperglycemia lead to alterations of diabetic myocardial biochemical indicators (CK and LDH). In line with this, Zhang et al [17] have shown that, serum levels of CK and LDH are significantly increased in streptozotocin-induced diabetic mouse models at 8 weeks. Moreover, Hou et al [18] have also found that, streptozotocin and high-fat diet-induced diabetic cardiomyopathy are accompanied with significantly elevated CK-MB and LDH levels in rats at 16 weeks.…”

Section: Discussionmentioning

confidence: 63%

Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy

Zeng

Xiao

et al. 2017

Lipids Health Dis

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BackgroundThe role of 1,25-dihydroxyvitamin D3 (vitamin D) in the apoptosis of diabetic cardiomyopathy (DCM) is unclear. This study is to investigate the effects of vitamin D on the pathological changes in rats with DCM.MethodsRats were randomly divided into the control, model, and treatment groups. DCM model was established by the high-fat and -sugar diet. Plasma glucose, body weight, heart weight, heart weight index, and serum levels of lactate dehydrogenase (LDH) and creatine kinase (CK) were determined. Heart tissue morphology was detected with histochemical staining. Expression levels of Fas and FasL were detected with RT-PCR and immunohistochemistry.ResultsCompared with the control group, the body weights and heart weights were significantly declined, while the plasma glucose levels and heart weight indexes were significantly elevated, in the model group (P < 0.05). However, vitamin D significantly reversed the pathological changes in DCM rats (P < 0.05). Moreover, the serum levels of LDH and CK were significantly increased in the models, which were significantly decreased by vitamin D (P < 0.05). HE staining showed that, vitamin D significantly alleviated the histological changes of myocardial cells in DCM rats. In addition, the mRNA and protein expression levels of Fas and FasL were significantly elevated in the models (P < 0.05), which were significantly declined by vitamin D (P < 0.05).ConclusionVitamin D could alleviate pathological changes, reduce Fas/FasL expression, and attenuate myocardial cell apoptosis in DCM rats, which might be used as a potential effective therapy for the disease.

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Section: Discussionmentioning

confidence: 63%

Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy

Zeng

Xiao

et al. 2017

Lipids Health Dis

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“…The effects of DOE on DCM were evident. However, the severe cardiac remodeling, such as hypertrophy and fibrosis, during the 8-week period of DM [50] , needs to be further confirmed in future studies.…”

Section: Magnolia Plant Extracts (Bl153 or 4-o-methylhonokiol)mentioning

confidence: 93%

“…Dendrobium officinale Extract (DOE): was shown to elevate the antioxidant SOD and decrease the production of malondialdehyde (MDA), the accumulation of lipid, and the expression of the fibrotic factors TGF-β, collagen-1, and fibronectin, as well as the inflammatory factors NF-κB, tumor necrosis factor alpha, and interleukin-1 beta, in the hearts of STZ induced diabetic mice [50] . DOE at 300 mg/kg also had a significant inhibitory impact on hyperglycemia and cardiac hypertrophy [50] . The effects of DOE on DCM were evident.…”

Section: Magnolia Plant Extracts (Bl153 or 4-o-methylhonokiol)mentioning

confidence: 99%

The Use of Natural Products in the Management of Diabetes: The Current Trends

Ogunmiluyi

2020

J. Drug Delivery Ther.

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Natural products have played and continue to play a great role in the management of different diseases. Natural products are usually believed to be safer, cheaper, easily available and sometimes more efficacious than purely synthetic drugs. Diabetes mellitus is a major health problem in the world. There is no cure for diabetes. With the increase in a number of newer drugs for diabetes, there is the possibility of a wide range of side effects that vary from one drug to another. It is, therefore, essential to practice effective methods of the treatment and management of diabetes. Hence, the need to explore antidiabetic drugs of natural origin with minimal side effects is highly essential. This review provides a scientific perspective on the usage and research of natural traditional remedies in the management of diabetes. The aim of the present review is to provide a comprehensive and concise overview of the previously reported clinical trials of antioxidative natural products in the management of diabetes. Keywords: Diabetes, Natural products, Hyperglycemia, Diabetic complications,

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“…Dendrobium officinale is one of the most valuable herbal plants and has been used for centuries as a herbal medicine in China and many other countries of South Asia [4]. In medicinal practice, it is used to nourish yin and enhance the production of body fluid, as well as to provide beneficial effects to the stomach and liver, moisten the lung, modulate the body's immune functions, and so on [5].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and Antioxidant Properties of the Degradations of Polysaccharides from Dendrobium officinale and Their Suitable Molecular Weight Range on Inducing HeLa Cell Apoptosis

Zhang

Luo

Wei

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Different molecular weight polysaccharides of Dendrobium officinale (DOPs) have gradually attracted attention because of their broad biological activities. They, however, remain poorly defined whether their antitumor activity is associated with molecular weight. In this study, the physicochemical, antioxidant, and antitumor properties of DOPs, including the crude polysaccharide (DOP) and its six degradation fractions (DOP1–DOP6) extracted from Dendrobium officinale, were determined. Consequently, DOPs were mainly composed of different ratios of mannose and glucose as follows: 5.15 : 1, 4.62 : 1, 4.19 : 1, 4.46 : 1, 4.32 : 1, 4.29 : 1, and 4.23 : 1, and their molecular weights were significantly different ranging from 652.29 kDa to 11.10 kDa. With the concentration increase of DOPs, the scavenging capacity against OH and DPPH free radicals increased. The antitumor ability of DOPs was different that DOP1–DOP5 (Mw: 176.29 kDa–28.48 kDa) exhibited the best antiproliferation activity than DOP (Mw: 652.29 kDa) and DOP6 (Mw: 11.10 kDa) in HeLa cells rather than PC9, A549, and HepG2 cells. Moreover, it is worth mentioning that DOP1 and DOP5 showed stronger capability on inducing apoptosis of HeLa cells than DOP and DOP6 via the mitochondrial pathway by upregulating the ratio of the Bax/Bal-2 mRNA expression. The results demonstrated that DOPs can be used as the potential natural antioxidant and antitumor products in pharmaceutical industries, and the molecular weight is a crucial influential factor of their antitumor activity that 28.48 kDa–176.29 kDa is a suitable range we may refer to.

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Dendrobium officinale Kimura et Migo attenuates diabetic cardiomyopathy through inhibiting oxidative stress, inflammation and fibrosis in streptozotocin-induced mice

Cited by 63 publications

References 29 publications

Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy

Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy

The Use of Natural Products in the Management of Diabetes: The Current Trends

Physicochemical and Antioxidant Properties of the Degradations of Polysaccharides from Dendrobium officinale and Their Suitable Molecular Weight Range on Inducing HeLa Cell Apoptosis

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