Dendronized heparin−doxorubicin conjugate based nanoparticle as pH-responsive drug delivery system for cancer therapy

She, Wenchuan; Li, Ning; Luo, Kui; Guo, Chuanbin; Wang, Gang; Geng, Yanyan; Gu, Zhongwei

doi:10.1016/j.biomaterials.2012.12.017

Cited by 249 publications

(157 citation statements)

References 67 publications

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“…Other conjugates have been designed as delivery systems for anticancer drugs, such as Doxorubicin [133]. An orally active 6-O-desulfated Nadroparin conjugate with deoxycholate (6ODS-LHbD) was found to inhibit angiogenesis and bone destructive arthritis in experimental models [134].…”

Section: Heparin Conjugates and Orally Delivery Systemsmentioning

confidence: 99%

Old and new applications of non-anticoagulant heparin

Cassinelli

Naggi

2016

International Journal of Cardiology

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Section: Heparin Conjugates and Orally Delivery Systemsmentioning

confidence: 99%

Old and new applications of non-anticoagulant heparin

Cassinelli

Naggi

2016

International Journal of Cardiology

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“…This delivery system demonstrated pH-dependent release of its cargo and showed potent cytotoxic effects against folate receptor-positive cancer cells. In other studies, dendronized heparin drug conjugates have been used for cancer therapy (52). Dendrimers are branched polymers that form tree-like nanoscaled structures.…”

Section: Nanoparticle Platforms: Emerging Translational Nanodrug Delimentioning

confidence: 99%

“…When complexed with heparin, the nanoparticle displayed pH sensitivity imparting controlled delivery of doxorubicin at acidic pH ranges in a mouse breast tumor model. The dendronized heparin-conjugated nanoparticle displayed potent anti-angiogenic and strong anti-tumorigenic activity (52).…”

Section: Nanoparticle Platforms: Emerging Translational Nanodrug Delimentioning

confidence: 99%

Nanodrug Delivery Systems: A Promising Technology for Detection, Diagnosis, and Treatment of Cancer

et al. 2014

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Abstract. Nanotechnology has enabled the development of novel therapeutic and diagnostic strategies, such as advances in targeted drug delivery systems, versatile molecular imaging modalities, stimulus responsive components for fabrication, and potential theranostic agents in cancer therapy. Nanoparticle modifications such as conjugation with polyethylene glycol have been used to increase the duration of nanoparticles in blood circulation and reduce renal clearance rates. Such modifications to nanoparticle fabrication are the initial steps toward clinical translation of nanoparticles. Additionally, the development of targeted drug delivery systems has substantially contributed to the therapeutic efficacy of anti-cancer drugs and cancer gene therapies compared with nontargeted conventional delivery systems. Although multifunctional nanoparticles offer numerous advantages, their complex nature imparts challenges in reproducibility and concerns of toxicity. A thorough understanding of the biological behavior of nanoparticle systems is strongly warranted prior to testing such systems in a clinical setting. Translation of novel nanodrug delivery systems from the bench to the bedside will require a collective approach. The present review focuses on recent research efforts citing relevant examples of advanced nanodrug delivery and imaging systems developed for cancer therapy. Additionally, this review highlights the newest technologies such as microfluidics and biomimetics that can aid in the development and speedy translation of nanodrug delivery systems to the clinic.

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“…She et al [9] prepared dendronized heparin conjugated with DOX through acid-labile hydrazone linkages using the reaction scheme shown in Figure 12. Azide-functionalized heparin, 26, was synthesized in PBS in the presence of EDC hydrochloride and N-hydroxysulfosuccinimide (sulfo-NHS).…”

Section: Heparin-doxorubicin Conjugates With Acid-labile Hydrazone LImentioning

confidence: 99%

“…Negatively charged species would be "less filterable" because of the negative charge of the glomerular membrane. Some charge-reversible and pH-responsive polysaccharides [7][8][9] discussed in this review can be used to achieve both these functionalities.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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Self-assembling polysaccharide nanostructures have moved to the forefront of many fields due to their wide range of functional properties and unique advantages, including biocompatability and stimulus responsiveness. In particular, the field of controlled release, which involves influencing the location, concentration, and efficacy of active pharmaceutical ingredients (APIs), diagnostics, nutrients, or other bioactive compounds, has benefited from polysaccharide biomaterials. Nanostructure formation, stimulus responsiveness, and controlledrelease performance can be engineered through facile chemical functionalization and noncovalent intermolecular interactions. This review discusses polysaccharide nanoparticles, designed for targeted and time-controlled delivery of emerging APIs, with improved in vivo retention, stability, solubility, and permeability characteristics. Topics covered include nanoparticles of cyclodextrin and cyclodextrin-containing polymers, hydrophobically modified polysaccharides, polysaccharide nanoparticles that respond to pH, temperature, or light stimulus, polysaccharide prodrug complexes, polysaccharide complexes with lipids and proteins, and other polysaccharide polyelectrolyte complexes.

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Dendronized heparin−doxorubicin conjugate based nanoparticle as pH-responsive drug delivery system for cancer therapy

Cited by 249 publications

References 67 publications

Old and new applications of non-anticoagulant heparin

Old and new applications of non-anticoagulant heparin

Nanodrug Delivery Systems: A Promising Technology for Detection, Diagnosis, and Treatment of Cancer

Self-assembled polysaccharide nanostructures for controlled-release applications

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