2022
DOI: 10.21203/rs.3.rs-2017001/v1
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Denervation Aggravates Renal Ischemia Reperfusion Injury via BMAL1-mediated Nrf2/ARE pathway

Abstract: Background Denervation is an inevitable pathological situation of renal graft. This study was to explore the change of clock gene rhythm under renal denervation (RDN) and its effect on renal function and oxidative stress during renal ischemia-reperfusion (IR) injury. Method C57/BL6 mice were randomly divided into 4 groups at daytime 7AM (zeitgeber time [ZT] 0) or at nighttime 7PM (ZT12) in respectively: Sham (S) group, RDN group, IR group and RDN+ IR (DIR) group. Renal pathological and functional changes were… Show more

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