Deneysel Hipertansiyon Oluşturulan Sıçanlarda Rosuvastatinin Böbrek Üzerine Koruyucu Etkileri

Abstract

Hypertension is responsible for approximately 30% of patients who reach end-stage renal disease. Caspase-3 is an important protein in the apoptosis of renal tubular epithelial cells. The presence of fibrillin-1(FBN1) microfibrils in the structure of the kidney glomerulus causes changes in FBN1 levels in the hypertensive kidney. Statin therapy is known to reduce the risk of developing kidney disease. In this study, the changes in caspase-3 and FBN1 in the kidney tissue of rats with hypertension using N-Nitro-L-Arginine Methyl Ester (L-NAME) were investigated along with how rosuvastatin affected the changes caused by hypertension on these proteins.
 To induce hypertension, rats were given L-NAME for 7 weeks. After the second week, rosuvastatin was given by oral gavage for 5 weeks. Blood pressure values were evaluated on days 0, 14, 28, 42. At the end of the experiment, all rats were sacrificed and caspase-3 and FBN1 levels were evaluated.
 Blood pressures were found to be higher in the hypertension group on the 14th, 28th, and 42nd days (p