Dengue and dengue haemorrhagic fever: Indian perspective

Chaturvedi, U. C.; Nagar, Rachna

doi:10.1007/s12038-008-0062-3

Cited by 88 publications

(79 citation statements)

References 61 publications

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“…1 Dengue an emerging disease has an endemicity in 31 states and union territories of India. [2][3][4] In 2017, Tamil Nadu has reported 14.5% of the national burden of dengue cases.…”

Section: Introductionmentioning

confidence: 99%

A cross sectional study on knowledge, attitude and practice of dengue fever among high school students in Villupuram municipality of Villupuram

Singaravel¹,

Kandaswamy²

2018

Int J Community Med Public Health

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Background: School-based education is an important way of transfer of knowledge and practices of dengue from classrooms to homes which helps to maintain clean environment for source reduction of dengue. Thus, this study was conducted with the main purpose of examining the knowledge, attitude and practices of dengue fever among school children in Villupuram. Methods: The study area was at high school students of Villupuram municipality from November 2017 to December 2017. The sample size is calculated from Dimbulagedara et al study where the prevalence was 47.2%. Considering Confidence level of 95%, relative precision of 7% the sample size derived was 216. Multistage sampling was used. The required information obtained by means of validated questionnaire. Results: Majority were of 14 years. More than 75% had a good knowledge on breeding source of infection, 50% were not aware that trashes were a breeding source with a significant p value of <0.05 between age and knowledge. The major source of knowledge was the school. More than half of them were of attitudes that they are not at risk of dengue. 59.7% of the respondents felt they were scared if they were to be infected. Removal of water stagnation (80.1%) was the commonly practiced preventive measures. Conclusions: School students had adequate basic knowledge regarding dengue. There were some misconceptions regarding to dengue. Personal protection and trash removal was least practiced which can be made successful by behaviour change, communication.

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“…1 Dengue an emerging disease has an endemicity in 31 states and union territories of India. [2][3][4] In 2017, Tamil Nadu has reported 14.5% of the national burden of dengue cases.…”

Section: Introductionmentioning

confidence: 99%

A cross sectional study on knowledge, attitude and practice of dengue fever among high school students in Villupuram municipality of Villupuram

Singaravel¹,

Kandaswamy²

2018

Int J Community Med Public Health

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“…5 Over the last few decades, epidemiology of dengue has rapidly changed which has led to a dramatic expansion in India. 6 In South East Asia (SEA) there is a substantial economic and disease burden caused by dengue. When compared to Japanese encephalitis, upper respiratory tract infections and hepatitis B, the burden of dengue is 17 times higher.…”

Section: Introductionmentioning

confidence: 99%

Trend of morbidity and mortality of dengue in Tamil Nadu and Puducherry, South India

Sahanaa

Mishra

Bazroy

2017

Int J Community Med Public Health

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Background: Globally, dengue infection is a mosquito borne viral disease accounts for nearly 50 million cases per year. South East Asia (SEA), Western Pacific, Africa, Eastern Mediterranean and Latin America are all endemic for frequent outbreaks of dengue fever. The burden of dengue is 17 times higher in SEA countries as compared to Japanese encephalitis, upper respiratory tract infections and Hepatitis B. Thus a study was planned to assess the trend of morbidity and mortality of dengue for the period of five years from 2012 to 2016 in Puducherry and Tamil Nadu (TN), South India. Methods: The data were sourced from National Health Profile 2017, WHO vector borne disease fact sheets and official website of National Vector Borne Disease Control Program. Analysis of secondary data was done and results were tabulated. Graphs were plotted to study the trend of the disease. Results: There is a fall in the morbidity of Dengue cases whereas increase in the mortality over the period of five years (2012-2016) in Puducherry. In TN, there is a decrease in trend of morbidity over the past five years and mortality since 2015. However, there is a rising trend of disease in India. Conclusions: Considering the above facts there is no doubt that dengue is a public health problem in Puducherry and Tamil Nadu, which needs urgent action to reduce the burden of dengue.

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“…Dengue fever is a mosquito-transmitted viral disease that is currently spreading rapidly as the consequence of globalization, unplanned and unregulated urban development, improper water storage, unsatisfactory sanitary conditions and global warming (Chaturvedi and Nagar 2008). Aedes aegypti mosquitoes, which transmit dengue virus to people, also transmit the Zika virus that has spread to 52 countries and territories according to the World Health Organization (www.who.int).…”

Section: Introductionmentioning

confidence: 99%

Production of dengue virus envelope protein domain III-based antigens in tobacco chloroplasts using inducible and constitutive expression systems

et al. 2016

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Dengue fever is a disease in many parts of the tropics and subtropics and about half the world's population is at risk of infection according to the World Health Organization. Dengue is caused by any of the four related dengue virus serotypes DEN-1, -2, -3 and -4, which are transmitted to people by Aedes aegypti mosquitoes. Currently there is only one vaccine (Dengvaxia Ò ) available (limited to a few countries) on the market since 2015 after half a century's intensive efforts. Affordable and accessible vaccines against dengue are hence still urgently needed. The dengue envelop protein domain III (EDIII), which is capable of eliciting serotype-specific neutralizing antibodies, has become the focus for subunit vaccine development. To contribute to the development of an accessible and affordable dengue vaccine, in the current study we have used plant-based vaccine production systems to generate a dengue subunit vaccine candidate in tobacco. Chloroplast genome engineering was applied to express serotypespecific recombinant EDIII proteins in tobacco chloroplasts using both constitutive and ethanol-inducible expression systems. Expression of a tetravalent antigen fusion construct combining EDIII polypeptides from all four serotypes was also attempted. Transplastomic EDIIIexpressing tobacco lines were obtained and homoplasmy was verified by Southern blot analysis. Northern blot analyses showed expression of EDIII antigen-encoding genes. EDIII protein accumulation levels varied for the different recombinant EDIII proteins and the different expression systems, and reached between 0.8 and 1.6 % of total cellular protein. Our study demonstrates the suitability of the chloroplast compartment as a production site for an EDIII-based vaccine candidate against dengue fever and presents a Gateway Ò plastid transformation vector for inducible transgene expression.

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Dengue and dengue haemorrhagic fever: Indian perspective

Cited by 88 publications

References 61 publications

A cross sectional study on knowledge, attitude and practice of dengue fever among high school students in Villupuram municipality of Villupuram

A cross sectional study on knowledge, attitude and practice of dengue fever among high school students in Villupuram municipality of Villupuram

Trend of morbidity and mortality of dengue in Tamil Nadu and Puducherry, South India

Production of dengue virus envelope protein domain III-based antigens in tobacco chloroplasts using inducible and constitutive expression systems

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