Dengue haemorrhagic fever outbreak in Karachi, Pakistan, 1994

Chan, Yee Cheun; Salahuddin, Naseem; Khan, Jehangir; Tan, Hwee Cheng; Seah, C.L.K.; Li, J.; Chow, Vincent T. K.

doi:10.1016/0035-9203(95)90412-3

Cited by 104 publications

(90 citation statements)

References 4 publications

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“…Sometimes all four dengue viruses are circulating simultaneously in areas where about 2/3 rd of the world's population lives and are infested with dengue vectors, mostly Aedes aegypti (12). At least seven dengue epidemics have been reported from Pakistan in last 20 years (13,14,15,16,17,18,19).…”

Section: Introductionmentioning

confidence: 99%

Dengue Virus Serotype 2 (DEN-2): the Causative Agent of 2011-Dengue Epidemic in Pakistan

Idrees¹,

Hussain²,

Rehman³

et al. 2012

Am. J. Biomed. Sci.

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Introduction: Dengue virus (DENV) is an arthropod-borne virus that belonged to the Flaviviridae viral family. Four known serotypes DEN-1 through DEN-4 do exist and circulate in diverse geographical regions of the world causing epidemics. The management of dengue patients, and especially dengue hemorrhagic fever (DHF)/Dengue shock syndrome (DSS) cases, has been a challenge in Pakistan now days. Method: We have carried out a comprehensive study of the current outbreaks of dengue virus infection on molecular level with the aim to find out the common serotype/s of DENV responsible for this outbreak using PCR, real-time PCR and nucleotide sequencing targeting the C-prM gene junction. For this purpose total 1129 serum samples received between from start of August till end of November 2011 from all the major hospitals of Lahore, Punjab at Division of Molecular Virology, National Centre of Excellence in Molecular Biology (CEMB) University of the Punjab Lahore were utilized for the DENV diagnosis and serotypes/genotypes analysis. Results: Male female ratio of the suspected dengue patients was 2.4:1. Their mean age were 31.14 + 16.03 (SD) years ranging from 9 months to 90 years. Out of these 1129 serum samples, total 930 (82.37%) were found infected with DENV. Out of the 930 DENV RNA positive samples, 893 (96.02%) had DEN-2 Am. J. Biomed. Sci. 2012, 4(4), 307-315; doi: 10.5099/aj120400307 © 2012 by NWPII. All rights reserved. 308 and 37 (3.97%) sample had concurrent infection with serotypes 2 and 3. Conclusion: Based on the results of this study we conclude that DEN-2 is the responsible genotype for the current dengue epidemic that started from the beginning of year 2011 and is continuing till now. The additional serotype detected in the current study was serotype 3 that remained in very low frequency in Pakistan for last several decades.

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Section: Introductionmentioning

confidence: 99%

Dengue Virus Serotype 2 (DEN-2): the Causative Agent of 2011-Dengue Epidemic in Pakistan

Idrees¹,

Hussain²,

Rehman³

et al. 2012

Am. J. Biomed. Sci.

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show abstract

“…albopictus) which is an increasingly important disease vector [3] has spread with the urbanization and poor sanitation, thus resulting in its increase [4] . In Pakistan, an outbreak of dengue hemorrhagic fever was first reported in Karachi in 1994 [5] and 11 024 confirmed cases of dengue fever including 40 deaths were reported in 2010. Now in 2011 again dengue outbreak occurs in Punjab with 100 confirmed cases daily reported [6] .…”

Section: Introductionmentioning

confidence: 99%

Isolation and efficacy of entomopathogenic fungus (Metarhizium anisopliae) for the control of Aedes albopictus Skuse larvae: suspected dengue vector in Pakistan

Bilal

Hassan

Khan

2012

Asian Pacific Journal of Tropical Biomedicine

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“…DHF began occurring in various parts of India in 1988 [21]. Pakistan reported cases of DHF in Karachi in 1994 [22].…”

Section: Recent History Of Dengue In Asiamentioning

confidence: 99%

Vigilance to Limit the Bidirectional Introduction and Co-circulation of Virus Serotypes Aims to Reduce Risk of Severe Dengue Disease in North East India

Barnett¹,

Taylor‐Robinson²

2016

J Emerg Infect Dis

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Dengue haemorrhagic fever outbreak in Karachi, Pakistan, 1994

Cited by 104 publications

References 4 publications

Dengue Virus Serotype 2 (DEN-2): the Causative Agent of 2011-Dengue Epidemic in Pakistan

Dengue Virus Serotype 2 (DEN-2): the Causative Agent of 2011-Dengue Epidemic in Pakistan

Isolation and efficacy of entomopathogenic fungus (Metarhizium anisopliae) for the control of Aedes albopictus Skuse larvae: suspected dengue vector in Pakistan

Vigilance to Limit the Bidirectional Introduction and Co-circulation of Virus Serotypes Aims to Reduce Risk of Severe Dengue Disease in North East India

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