Dengue is still an imported disease in China: A case study in Guangzhou

Sang, Shaowei; Bin, Chen; Wu, Haixia; Yang, Zhicong; Di, Biao; Wang, Lihua; Tao, Xiaoyan; Liu, Xiaobo; Liu, Qiyong

doi:10.1016/j.meegid.2015.03.005

Cited by 90 publications

(89 citation statements)

References 51 publications

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“…Since then, it occurred in Guangdong almost every year [6,7]. The dengue cases in this province were mainly caused by imported cases from surrounding dengue endemic countries and areas [8]. …”

Section: Introductionmentioning

confidence: 99%

Community Involvement in Dengue Outbreak Control: An Integrated Rigorous Intervention Strategy

et al. 2016

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BackgroundAn explosive outbreak of dengue fever occurred in Guangdong Province, China in 2014. A community-based integrated intervention was applied to control this outbreak in the capital city Guangzhou, where dengue epidemic was mainly caused by imported cases.Methodology/Principal FindingsWe used a time series generalized additive model based on meteorological factors to assess the effectiveness of this intervention. The results showed that there was significant reduction in mosquito density following the intervention, and there was a 70.47% (95% confidence interval: 66.07%, 74.88%) reduction in the reported dengue cases compared with the predicted cases after 12 days since the beginning of the intervention, we estimated that a total of 23,302 dengue cases were prevented.ConclusionsThis study suggests that an integrated dengue intervention program has significant effects to control a dengue outbreak in areas where dengue epidemic was mainly caused by imported dengue cases.

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Section: Introductionmentioning

confidence: 99%

Community Involvement in Dengue Outbreak Control: An Integrated Rigorous Intervention Strategy

et al. 2016

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“…This sequence and sequences from a representative strain from each country that might have introduced DENV into China were chosen to construct a phylogenetic tree (Sang et al 2015). Most sequences included in the phylogenetic analysis came from Southeast Asian countries between 2003 and 2014 and have relatively high genetic nucleotide and amino acid similarity with GZ02 (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…According to epidemiological data, strains from countries that had introduced DENV into Guangdong in the past few years were chosen for genetic analysis (Sang et al 2015; Peng et al 2012). Based on the percent nucleotide and amino acid identities to GZ02, one DENV-1 strain from each of these countries was chosen for phylogenetic analysis of the complete genome (Fig.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization and phylogenetic analysis of dengue virus type 1 in Guangdong in 2014

Wang

et al. 2016

SpringerPlus

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BackgroundDengue is one of the most important emerging diseases of humans, with no preventive vaccines or antiviral cures available currently. In 2014, the Southeast Asian region experienced an unprecedented outbreak of dengue, especially in Guangdong, China.Results The nucleotide sequences of the E gene from 23 patients sera of dengue virus type 1 (DENV-1) from Guangzhou, China, were determined. One isolate that was recovered from a patient with serious liver damage was designated GZ02. The whole genome sequence of GZ02 was amplified, and confocal microscopy and plaque reduction neutralization test were performed to investigate the replication kinetics in liver L02 cells. In the study, assembly and genetic comparisons showed 11 of those E gene nucleotide sequences were absolutely accordant, and the nucleic acid sequence divergence among the other strains had no marked difference.ConclusionsPhylogenetic analysis based on the E gene indicated that the 23 new strains were closely related to strains from Malaysia or Singapore. Two different genotypes (genotype I and III) of DENV-1 were co-circulating in Guangdong, Malaysia, and Singapore from 2013 to 2014. However, no recombination event was found after 2005 between DENV strains from Guangdong and Malaysia or Singapore. GZ02 had a significant replicative advantage over DG14 and the DV1 standard strain. Importation of DENV-1 from Southeast Asian countries may have been an important contributing factor to the 2014 outbreak in Guangdong.

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“…Among the countries in Southeast Asia, the incidences of dengue fever (DF) and dengue hemorrhagic fever (DHF) in Indonesia have been the highest since 2004 (9). Various studies showed dengue cases exported from Indonesia to China, Japan, and Australia (10)(11)(12). Therefore, epidemiological studies need to be conducted in Indonesia to clarify the evolution and migration of dengue virus.…”

Section: Communicated By Masayuki Saijomentioning

confidence: 99%

Dengue Virus Type 1 Strain Isolated in Indonesia Shows a Close Phylogenetic Relation with the Strains That Caused the Autochthonous Dengue Outbreak in Japan in 2014

et al. 2016

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Dengue is still an imported disease in China: A case study in Guangzhou

Cited by 90 publications

References 51 publications

Community Involvement in Dengue Outbreak Control: An Integrated Rigorous Intervention Strategy

Community Involvement in Dengue Outbreak Control: An Integrated Rigorous Intervention Strategy

Molecular characterization and phylogenetic analysis of dengue virus type 1 in Guangdong in 2014

Dengue Virus Type 1 Strain Isolated in Indonesia Shows a Close Phylogenetic Relation with the Strains That Caused the Autochthonous Dengue Outbreak in Japan in 2014

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