Dengue Typhoid Co-infection: a New Threat

Siddiqui, Mahmudur Rahman; Islam, Quazi Tarikul; Islam, Mohammad Shahidul

doi:10.3329/akmmcj.v10i1.43670

Cited by 1 publication

(2 citation statements)

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“…Body aches, myalgias, altered bowel patterns, and sore throat are common in both dengue fever and typhoid fever. Similar laboratory findings and physical signs in typhoid fever and dengue fever, including rash, mild splenomegaly, relative bradycardia, and neutropenia make differentiation almost impossible [ 16 ]. Other febrile illnesses should be considered, especially when the clinical course of a patient differs from the natural disease course or when a patient is unresponsive to standard treatment.…”

Section: Discussionmentioning

confidence: 99%

“…A case of dengue and typhoid co-infection in India was reported, but results of a sensitivity test were not provided [12]. In two patients with dengue fever, culture-proven Salmonella typhi was found to be sensitive to fluoroquinolones [13,14], and in four other patients, Salmonella typhi was found to be sensitive to cephalosporins [14][15][16][17]. The clinical condition of all the patients improved after treatment with fluoroquinolone and/or oral or parenteral cephalosporin.…”

Section: Table 2: Blood Culture and Sensitivity Reportmentioning

confidence: 99%

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Co-infection With Dengue Virus and Extensively Drug-Resistant Salmonella typhi

Amin¹,

Noor²,

Rahim³

et al. 2021

Cureus

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In South Asia, infectious diseases are associated with significant morbidity and mortality. Malaria, typhoid, and dengue are the most common infectious diseases, and patients may be co-infected with these diseases, resulting in diagnostic and treatment dilemmas. Dengue is caused by the Arboviridae family of viruses and is transmitted by Aedes aegypti . Dengue virus has four serotypes and the symptoms of dengue fever mimic those of other infectious diseases such as malaria, chikungunya, Zika virus disease, influenza A, enteric fever, and coronavirus disease 2019, which are also prevalent in areas of frequent dengue fever outbreak. Dengue fever is characterized by fever, severe myalgia, retro-orbital pain, skin rashes, and bone pain, which is why dengue fever is also referred to as breakbone fever. Patients with secondary dengue virus infection more commonly present with abdominal pain when compared with those with primary dengue virus infection. Salmonella typhi causes enteric fever, which is a human infection with no animal reservoir, but the symptoms of enteric fever closely resemble those of dengue fever. Concurrent infections with multiple organisms are especially difficult to diagnose. In this report, we present the case of a 15-year-old boy from Peshawar, Pakistan, who was co-infected with the dengue virus and extensively drug-resistant Salmonella typhi . To the best of our knowledge, this is the first reported case of co-infection with dengue virus and extensively drug-resistant Salmonella typhi.

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Section: Discussionmentioning

confidence: 99%