Dengue virus infection – a review of pathogenesis, vaccines, diagnosis and therapy

Kok, Boon Hui; Lim, Hui Ting; Lim, Chin Peng; Lai, Ngit Shin; Leow, Chiuan Yee; Leow, Chiuan Herng

doi:10.1016/j.virusres.2022.199018

Cited by 55 publications

(52 citation statements)

References 248 publications

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“…It is an RNA virus enclosing three types of structural proteins including capsid, envelope, and membrane, and seven non-structural (NS) proteins. 5…”

Section: Denguementioning

confidence: 99%

Review of dengue, zika and chikungunya infections in nervous system in endemic areas

Puccioni-Sohler,

Nascimento Soares,

Christo

et al. 2023

Arq Neuropsiquiatr

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Dengue, zika, and chikungunya are arboviruses of great epidemiological relevance worldwide. The emergence and re-emergence of viral infections transmitted by mosquitoes constitute a serious human public health problem. The neurological manifestations caused by these viruses have a high potential for death or sequelae. The complications that occur in the nervous system associated with arboviruses can be a challenge for diagnosis and treatment. In endemic areas, suspected cases should include acute encephalitis, myelitis, encephalomyelitis, polyradiculoneuritis, and/or other syndromes of the central or peripheral nervous system, in the absence of a known explanation. The confirmation diagnosis is based on viral (isolation or RT-PCR) or antigens detection in tissues, blood, cerebrospinal fluid, or other body fluids, increase in IgG antibody titers between paired serum samples, specific IgM antibody in cerebrospinal fluid and serological conversion to IgM between paired serum samples (non-reactive in the acute phase and reactive in the convalescent). The cerebrospinal fluid examination can demonstrate: 1. etiological agent; 2. inflammatory reaction or protein-cytological dissociation depending on the neurological condition; 3. specific IgM, 4. intrathecal synthesis of specific IgG (dengue and chikungunya); 5. exclusion of other infectious agents. The treatment of neurological complications aims to improve the symptoms, while the vaccine represents the great hope for the control and prevention of neuroinvasive arboviruses. This narrative review summarizes the updated epidemiology, general features, neuropathogenesis, and neurological manifestations associated with dengue, zika, and chikungunya infection.

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“…It is an RNA virus enclosing three types of structural proteins including capsid, envelope, and membrane, and seven non-structural (NS) proteins. 5…”

Section: Denguementioning

confidence: 99%

Review of dengue, zika and chikungunya infections in nervous system in endemic areas

Puccioni-Sohler,

Nascimento Soares,

Christo

et al. 2023

Arq Neuropsiquiatr

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“…Routine laboratory tests like complete blood count and coagulation tests are commonly used to detect and monitor for dengue‐associated complications of thrombocytopenia and coagulopathy 8 but are non‐specific. Similarly, abnormal results of serological tests like hemagglutination inhibition and plaque reduction neutralization can provide some support to corroborate dengue infection but are not diagnostic 9 . For a definitive diagnosis of dengue infection, advanced laboratory‐based techniques are required to detect the dengue virus, its viral ribonucleic acid, viral antigens, or anti‐dengue antibodies in the patient's blood 10 .…”

Section: Introductionmentioning

confidence: 99%

“…8 Other confirmatory tests use enzyme-linked immunosorbent assay methods to either detect viral antigens like the non-structural protein, NS1, or viral immunoglobin M and G antibodies in sera. Both these techniques require sophisticated equipment and skilled expertise, 9,11 are expensive, and cannot be readily deployed for high-volume real-time detection.…”

Section: Introductionmentioning

confidence: 99%

Wavelet scattering‐ and object detection‐based computer vision for identifying dengue from peripheral blood microscopy

Dsilva,

Tantri,

Sampathila

et al. 2024

Int J Imaging Syst Tech

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Dengue fever infection is a global health concern. Early disease detection is crucial for averting complications and fatality. Characteristic morphological changes in lymphocytes can be observed on a peripheral blood smear (PBS) in cases of dengue infection. In this research, we have developed automated computer vision models for dengue detection on PBS images using two approaches: wavelet scattering transform (WST)‐based feature engineering and classification and You Only Look Once (YOLO)‐based deep transfer learning for object detection. In the former, Morlet wavelet scattering features extracted from lymphocytes were used as input for five shallow classifiers for image classification. Among these, the support vector machine achieved the best results of 98.7% accuracy using 10‐fold cross‐validation. In the latter, computer vision‐enabled object detection was implemented using five YOLOv8 scaled variants. Among these, YOLOv8s and YOLOv8l attained identical best mean accuracy of 99.3% ± 1.4% across five independent experiments. Our results confirmed the feasibility and excellent diagnostic accuracy for both WST‐ and YOLOv8‐enabled computer vision approaches for diagnosing dengue infection in PBS images. This research incorporates deep machine learning along with AI technology to enhance understanding and capabilities in automated Dengue diagnosis. The significance of this research extends to the broader domain of mosquito‐borne illnesses. However, it is important to note that the findings are limited to the dataset used by the researchers.

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“…Dengue fever is the most prevalent human arthropod-borne viral infection in tropical and subtropical countries, further expanding due to climate change and urbanization [ 1 ]. Already endemic in more than 100 countries [ 2 , 3 ], this arboviral disease can cause a panel of clinical forms ranging from self-resolving flu-like illness syndromes with or without warning signs to severe dengue with plasma leakage, bleeding or organ impairment evolving to death [ 4 ]. Given the number of exposed people around the world (around 3.9 billion) and its potentially severe clinical forms, this disease poses a significant public health and economic burden in endemic areas and in Northern hemisphere countries where dengue viruses (DENV) and its Aedes spp.…”

Section: Introductionmentioning

confidence: 99%

A Six Years (2010–2016) Longitudinal Survey of the Four Serotypes of Dengue Viruses in Lao PDR

Balière

Calvez²,

Thiberge

et al. 2023

Microorganisms

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Dengue fever is the most prevalent arthropod-borne viral infection of humans in tropical and subtropical countries. Since 1979, dengue has been reported to be endemic in the Lao People’s Democratic Republic (PDR), as in many countries in Southeast Asia, with a complex circulation of the four dengue viruses’ serotypes (DENV-1 to DENV-4). By sequencing the complete envelope protein, we explored a panel of samples from five Lao Provinces (Vientiane capital, Luangprabang, Bolikhamxay, Saravane, Attapeu) to enrich knowledge about the co-circulation of DENVs in Lao PDR between 2010 and 2016. Phylogenetic analyses highlighted the specific circulation of DENV-1 genotype I, DENV-2 genotype Asian I, DENV-4 genotype I and the co-circulation of DENV-3 genotype II and III. The continuous co-circulation of the four serotypes was underlined, with genotype or cluster shifts among DENV-3 and DENV-1. These data suggested the emergence or re-emergence of DENV strains associated with epidemic events, potentially linked to the exchanges within the territory and with neighboring countries. Indeed, the increasing local or regional connections favored the dissemination of new isolates or new clusters around the country. Since 2012, the surveillance and alert system created in Vientiane capital by the Institut Pasteur du Laos appears to be a strategic tool for monitoring the circulation of the four serotypes, especially in this endemic country, and allows for improving dengue epidemiological knowledge to anticipate epidemic events better.

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Dengue virus infection – a review of pathogenesis, vaccines, diagnosis and therapy

Cited by 55 publications

References 248 publications

Review of dengue, zika and chikungunya infections in nervous system in endemic areas

Review of dengue, zika and chikungunya infections in nervous system in endemic areas

Wavelet scattering‐ and object detection‐based computer vision for identifying dengue from peripheral blood microscopy

A Six Years (2010–2016) Longitudinal Survey of the Four Serotypes of Dengue Viruses in Lao PDR

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