Dengue virus infection: a major cause of acute hepatic failure in Thai children

Poovorawan, Yong; Hutagalung, Yanee; Chongsrisawat, Voranush; Boudville, Irving Charles; Bock, Hans L.

doi:10.1179/146532806x90565

Cited by 66 publications

(54 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[8][9][10][11][12][13][14][15][16][17][18] The liver enzymes were elevated in 45.4% of the cases similar to other studies 36.4%-96%. Commonest abdominal USG finding was gall bladder edema in 90.8% (156/174) of the cases.…”

Section: Discussionsupporting

confidence: 72%

“…8 In recent studies from India and Thailand, dengue infection was the most important cause of acute hepatic failure in children contributing to 18.5% and 34.3% of the cases respectively. 15,16 Hence early recognition and prompt initiation of appropriate supportive treatment can decrease the morbidity and mortality. Most of the data reported on abnormal liver functions in dengue are retrospective.…”

Section: Introductionmentioning

confidence: 99%

“…9,11,14,18 The incidence of hepatic dysfunction is more in dengue shock syndrome and Dengue hemorrhagic fever. 6,[8][9][10][11][12][13][14][15][16][17] Aminotransferase levels are useful in predicting the occurrence of hepatic dysfunction and spontaneous bleeding. 8 In recent studies from India and Thailand, dengue infection was the most important cause of acute hepatic failure in children contributing to 18.5% and 34.3% of the cases respectively.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Study of hepatic dysfunction of dengue fever in children

Selvan

Saravanan

Murthy

et al. 2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Dengue is a major international health concern that is prevalent in tropical and sub-tropical countries. It is estimated that worldwide nearly 2.5 billion people continue to live at risk of contracting the infection while 50 million cases and 24,000 deaths tend to occur in 100 endemic countries. Hepatic dysfunction is common in dengue fever and the degree of liver dysfunction in children varies from mild injury with to severe injury.Methods: Prospective and descriptive study was conducted on all the laboratory confirmed cases of dengue fever in children admitted at SIMS and RC over a period of 1 year from Dec 2015 to Nov 2016 both clinically and biochemically.Results: This study reveals, the prevalence of hepatic dysfunction in 30.6% (174/568) of the cases. Among the gender and age, majority of the hepatic dysfunction were seen in males 55.7% (97/174) and in the age group of 10-18 years 44.2% (77/174). Based on the severity, majority of hepatic dysfunction was seen in severe dengue cases 59.2% (103/174). Among clinical findings, most common symptom was jaundice 27.5% (48/174) and commonest sign was hepatomegaly 39.6% (69/174). The commonest liver function test altered was AST level in 45.4% (79/174) of the cases. Commonest abdominal USG finding was gall bladder edema in 90.8% (156/174) of the cases. The mortality was nil in this study.Conclusions: This study concludes prevalence of hepatic dysfunction was seen 30.6%, most of them seen in severe dengue 59.2% of the cases suggesting any febrile child with hepatic dysfunction, dengue infection should be suspected.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Study of hepatic dysfunction of dengue fever in children

Selvan

Saravanan

Murthy

et al. 2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…In a study by Kumar et al (4), dengue infection was responsible for 18.5% of acute hepatic failure of children in India. However, Poovorawan et al reported that 34.3% of their cases pediatric dengue infections were the major cause of acute hepatic failure in Thai children (9). Jaundice in dengue fever has been associated with fulminant hepatic failure and by itself is a poor prognostic factor (10).…”

Section: Discussionmentioning

confidence: 99%

Dengue Hepatitis: A Case Report

Kalenahalli

Priyadarshini

Manjunath

et al. 2015

Arch Clin Infect Dis

View full text Add to dashboard Cite

“…9 In contrast to these adult studies, it is noteworthy that in dengue endemic countries, dengue may be an important cause of acute liver failure in children. 10,11 The mechanism of liver involvement in dengue infection is not clear and may explain a direct injury to liver cells or an immunological response. 12 AST is expressed in the heart, skeletal muscle, red blood cells, kidneys, brain and liver, while ALT is secreted primarily by the liver cells.…”

Section: Discussionmentioning

confidence: 99%