Dengue virus infection in travellers returning to Berlin, Germany: clinical, laboratory, and diagnostic aspects

Teichmann, Dieter; Göbels, K; Niedrig, Matthias; Grobusch, Martin P.

doi:10.1016/j.actatropica.2003.11.004

Cited by 20 publications

(17 citation statements)

References 23 publications

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“…Many thousands of dengue fever cases are in the tropics and subtropics over the world each year, with fever (approximately 5 days), intense headache, retrobulbar pain, myalgia, arthralgia, stiff neck, and rash. Sometimes, severe dengue hemorrhagic fever (petechial hemorrhages in the skin and internal organs) occurs with shock syndrome and is often fatal (Solomon and Mallewa 2001;Teichmann et al 2004).…”

Section: Dengue Virus (Flavivirus Flaviviridae)mentioning

confidence: 99%

“…Several tens of human cases are introduced each year from tropical regions, as reported by many European countries (Teichmann et al 2004). However, Dengue-1 and Dengue-2 viruses caused a huge outbreak in Greece in 1927-1928(Theiler et al 1960Theiler and Downs 1973); 650,000 persons out of 704,000 inhabitants of Athens and Pireus contracted the disease between August and September 1928, and 1,061 died of dengue hemorrhagic fever (Papaevangelou and Halstead 1977;Halstead and Papaevangelou 1980).…”

Section: Dengue Virus (Flavivirus Flaviviridae)mentioning

confidence: 99%

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Mosquito-borne viruses in Europe

2008

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The number of mosquito-borne viruses ('moboviruses') occurring in Europe since the twentieth century now stands at ten; they belong to three families-Togaviridae (Sindbis, Chikungunya), Flaviviridae (West Nile, Usutu, Dengue), and Bunyaviridae (Batai, Tahyna, Snowshoe hare, Inkoo, Lednice). Several of them play a definite role in human or animal pathology (Sindbis, Chikungunya, Dengue, West Nile, Tahyna). Mobovirus outbreaks are strictly determined by the presence and/or import of particular competent vectors of the disease. Ecological variables affect moboviruses considerably; the main factors are population density of mosquito vectors and their vertebrate hosts, intense summer precipitations or floods, summer temperatures and drought, and presence of appropriate habitats, e.g., wetlands, small water pools, or intravillan sewage systems. A surveillance for moboviruses and the diseases they cause in Europe is recommendable, because the cases may often pass unnoticed or misdiagnosed not only in free-living vertebrates but also in domestic animals and even in humans.

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Section: Dengue Virus (Flavivirus Flaviviridae)mentioning

confidence: 99%

Section: Dengue Virus (Flavivirus Flaviviridae)mentioning

confidence: 99%

Mosquito-borne viruses in Europe

2008

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“…Although it can be temporarily incapacitating and accompanied by minor bleedings, travel-associated DF is usually a benign condition. Some travellers, however, may develop severe complications such as encephalitis [4], meningitis [5], cranial neuropathies [6 Á8], various ophthalmological manifestations [9], pancreatitis [5], or dengue heamorrhagic fever (DHF) [1,10 Á12], a potentially life-threatening condition characterized by acute plasma leakage, pronounced thrombocytopenia and bleedings. Fatalities are rare but were reported in a Bangladeshi male residing in the United Kingdom who developed DHF and hepatic failure after visiting his country of origin [11], in a British student infected in India in 1997 (P. Chiodini, personal communication), and in a 28-y-old US female who developed DHF after a holiday trip to Mexico in 2005 [12].…”

Section: Introductionmentioning

confidence: 99%

Fatal subarachnoidal haemorrhage in a Norwegian traveller with dengue virus infection

Jensenius

Berild

Ormaasen

et al. 2007

Scandinavian Journal of Infectious Diseases

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We present a Norwegian female in her thirties who acquired dengue fever caused by dengue virus serotype 2 while travelling to Mexico. When hospitalised 3 days after symptom onset, the patient had severe headache, fever, rash and a positive tourniquet test, but did not fulfil the criteria of dengue haemorrhagic fever (DHF). Five days later she developed a fatal subarachnoidal haemorrhage. A post-mortem examination failed to reveal any intracranial arterial aneurysm. Our case was consistent with so called 'dengue fever with haemorrhages', a recently described entity that mainly affects adults and may cause severe bleedings also in the absence of DHF.

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“…Human infections caused by these seven flaviviruses are diagnosed predominantly by serological methods; mainly by IgM Capture ELISAs [Schoub and Blackburn, 2000]. Due to the slow development of specific antibodies, and the high serological cross-reactivity among the flaviviruses, molecular diagnostics are in many cases more suitable [Sa-ngasang et al, 2003;Teichmann et al, 2004]. The molecular methods used to date have mainly been based on RT-PCR that target conserved regions of the RNA genome [Lindenbach and Rice, 2001].…”

mentioning

confidence: 99%

DNA microarray technique for detection and identification of seven flaviviruses pathogenic for man

et al. 2005

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A flavivirus microarray was developed for detection and identification of yellow fever (YF), West Nile, Japanese encephalitis (JE), and the dengue 1-4 viruses, which are causing severe human disease all over the world. The microarray was based on 500-nucleotide probe fragments from five different parts of the seven viral genomes. A low-stringent amplification method targeting the corresponding regions of the viral genomic RNA was developed and combined with hybridization to the microarray for detection and identification. For distinction of the generated virus-specific fluorescence-patterns a fitting analysis procedure was adapted. The method was verified as functional for all seven flaviviruses and the strategy for the amplification, combined with the long probes, provided a high tolerance for smaller genetic variability, most suitable for these rapidly changing RNA viruses. A potentially high detection and identification capacity was proven on diverged strains of West Nile and dengue viruses. The lower limit for detection was equivalent, or better, when compared to routinely used RT-PCR methods. The performance of the method was verified on human patient samples containing dengue viruses, or normal human serum spiked with YF or JE viruses. The results demonstrated the ability of the flavivirus microarray to screen simultaneously a sample for several viruses in parallel, in combination with a good lower limit of detection.

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Dengue virus infection in travellers returning to Berlin, Germany: clinical, laboratory, and diagnostic aspects

Cited by 20 publications

References 23 publications

Mosquito-borne viruses in Europe

Mosquito-borne viruses in Europe

Fatal subarachnoidal haemorrhage in a Norwegian traveller with dengue virus infection

DNA microarray technique for detection and identification of seven flaviviruses pathogenic for man

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