Dengue virus life cycle: viral and host factors modulating infectivity

Rodenhuis-Zybert, Izabela A.; Wilschut, Jan; Smit, Jolanda M.

doi:10.1007/s00018-010-0357-z

Cited by 397 publications

(350 citation statements)

References 199 publications

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“…Its genome is approximately 11, 000 nucleotides, and encodes three structural proteins, including the C (core), M (membrane) and E (envelope) proteins; seven nonstructural proteins, including NS1, NS2a, NS2b, NS3, NS4a, NS4b and NS5 (Drumond et al, 2012); and short non-coding regions at both the 5′-and 3′-ends (WHO, 2009;Rodenhuis-Zybert et al, 2010). DENV can be grouped into five antigenically distinct serotypes (DENV-1, -2, -3, -4 and -5) and each of these serotypes can be sub-classified into several genotypes based on their E gene sequences.…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

Pan

et al. 2017

Virol. Sin.

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The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic inGuangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains. Additionally, 6 genotype I strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype I strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype V strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou.

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Section: Introductionmentioning

confidence: 99%

Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

Pan

et al. 2017

Virol. Sin.

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“…The resulting polyprotein is cleaved by virus and host proteases into three structural and at least seven nonstructural proteins (4,5). The capsid (C) protein functions as a structural component of the DENV virion, encapsulating the ssRNA genome of the virus (4,5).…”

mentioning

confidence: 99%

Nucleolin Interacts with the Dengue Virus Capsid Protein and Plays a Role in Formation of Infectious Virus Particles

Balinsky

Schmeisser

Ganesan

et al. 2013

J Virol

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Dengue virus (DENV), a member of the genus Flavivirus, causes a spectrum of disease in humans that can range from a mild febrile illness to potentially fatal hemorrhage or shock syndromes. Four serotypes of DENV (DENV-1, -2, -3, and -4) are transmitted by the bite of a mosquito vector and are responsible for more than 50 million infections each year. Infection with one DENV serotype does not confer lasting immunity to the others (1-3). The most severe clinical manifestations of dengue are associated with secondary infections by a heterologous DENV serotype (2). Increasing urbanization, cocirculation of multiple DENV serotypes within the same geographic area, and expansion of its insect vector contribute to the increasing importance of dengue to global health (2, 3).DENV contains a positive-sense single-stranded RNA (ssRNA) genome that is translated as a single open reading frame. The resulting polyprotein is cleaved by virus and host proteases into three structural and at least seven nonstructural proteins (4, 5). The capsid (C) protein functions as a structural component of the DENV virion, encapsulating the ssRNA genome of the virus (4, 5). The DENV C protein is composed of four alpha helices with an unstructured amino terminus and forms antiparallel homodimers.

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“…The 3400 amino acid long polyprotein encoded by ZIKV is co and posttranslationally processed by host and virus proteases that give rise to three structural proteins namely as Capsid (C), pre-Membrane (prM) and Envelope (E) and seven non-structural proteins including NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 (Rodenhuis-Zybert et al, 2010). Similar to other Flavivirus, ZIKV follows the same replication cycle.…”

Section: Zikv Genomementioning

confidence: 99%

Current Advances in Zika Virus Transmission: Urgency for Effective Therapeutics and Prevention

Raj

Kumar

Haikerwal

et al. 2017

American Journal of Infectious Diseases

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Global emergence of Zika Virus (ZIKV) with prevalent outbreaks has been reported in numerous countries of South America, Central America and the Caribbean region. According to recent World Health Organization (WHO)-ZIKV situation report, 84 countries/territories/subnational areas represented with established mosquito-borne transmission of ZIKV. As of 10 August 2017, cumulative Zika cases and congenital syndrome associated with Zika virus reported by countries and territories in the Americas, 2015 -2017 includes 217,471 confirmed cases with the Case Fatality Rate (CFR) of 0.01% and 78.08 incidence rate. ZIKV has undoubtedly become a major threat in countries endemic for other Flavivirus infection. Factors such as urbanization, global trade and travel, tropical/sub-tropical climate, prevalence of Aedes vector and poor waste management altogether are responsible for ZIKV infection in Southeast Asian countries. The occurrence of co-infection by other Flavivirus (Dengue) and ZIKV have been reported in tropical/subtropical region, implying the role of sero-cross reactivity and initiating antibody dependent enhancement of ZIKV infection. The trans-placental transmission of ZIKV in pregnant women makes the fetus more susceptible to ZIKV infection. In order to control ZIKV infection, development of robust vaccine and effective antivirals are required urgently. This review majorly discusses about ZIKV epidemiology, modes of transmission, antibody dependent enhancement and prevention and control strategies.

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Dengue virus life cycle: viral and host factors modulating infectivity

Cited by 397 publications

References 199 publications

Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

Nucleolin Interacts with the Dengue Virus Capsid Protein and Plays a Role in Formation of Infectious Virus Particles

Current Advances in Zika Virus Transmission: Urgency for Effective Therapeutics and Prevention

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