For several decades, the Journal of Public Policy & Marketing has stimulated and led debates with far-reaching implications for consumer well-being, global relationships and, ultimately, human survival. The challenges we face have not disappeared but intensified. Today, we must respond to climate change, manage a global pandemic, and address disparities and inequities that threaten our planet in ways we are yet to comprehend fully. However, the JPP&M community remains well-placed to inform responses to these crises. This article draws together perspectives on new and long-standing questions and challenges, as we highlight the increasing urgency of addressing inequities and embedding sustainability at the heart of policy-making. Yet, while progress addressing these complex questions often has been slow, we also identify compelling opportunities. Sound policies and good marketing and consumption practices in response to health crises, environmental degradation, injustice, automation, violence and war; the transformational benefits following Constructive Engagement offer hope that, even when faced with unprecedented challenges, human resilience and ingenuity can create meaningful responses. As we address chronic and novel problems, we are confident JPP&M’s community of researchers, policy makers, and advocates will continue to bring innovation, insight, and rigor, and play a leading role in discovering solutions, locally and globally.