Dense nanoparticles exhibit enhanced vascular wall targeting over neutrally buoyant nanoparticles in human blood flow

Thompson, Alex J.; Eniola‐Adefeso, Omolola

doi:10.1016/j.actbio.2015.04.005

Cited by 30 publications

(44 citation statements)

References 64 publications

(114 reference statements)

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“…An RBC effect was observed with silica spheres as they displayed better nearwall localization in the presence of RBCs than in pure buffer, likely resulting in the observed improvement in adhesion. Titanium spheres, which have a density around four times higher than that of blood, adhered at levels higher than polystyrene, but only in conditions where gravity or centrifugal force acted in the direction of adhesion [25]. Similar to what has been observed with polystyrene microspheres [23], both silica and titanium particles exhibited reduced adhesion efficiency as the WSR increased from 100 s −1 to 1000 s −1 [25].…”

Section: The Effect Of Particle Densitysupporting

confidence: 67%

“…Titanium spheres, which have a density around four times higher than that of blood, adhered at levels higher than polystyrene, but only in conditions where gravity or centrifugal force acted in the direction of adhesion [25]. Similar to what has been observed with polystyrene microspheres [23], both silica and titanium particles exhibited reduced adhesion efficiency as the WSR increased from 100 s −1 to 1000 s −1 [25]. In a VSFC, adhesion within the recirculation region increased for silica and titanium particles compared to polystyrene in both upright and inverted chambers.…”

Section: The Effect Of Particle Densitymentioning

confidence: 99%

“…Despite the wide range of densities of vascular-targeting materials, there have been limited investigations of the effect of particle density on vascular margination and adhesion. Particle density forces are usually regarded as negligible in describing particle motion relevant to physiological blood flow [25], since the hydrodynamic forces due to flow (for microparticles) and Brownian forces (for nanoparticles) are often orders of magnitude higher than density-dependent body forces such as gravitational and centrifugal forces [87]. Recently, Thompson et al have reported the effect of material density on the margination and adhesion efficiency of particles to the vascular wall [25].…”

Section: The Effect Of Particle Densitymentioning

confidence: 99%

“…Particle density forces are usually regarded as negligible in describing particle motion relevant to physiological blood flow [25], since the hydrodynamic forces due to flow (for microparticles) and Brownian forces (for nanoparticles) are often orders of magnitude higher than density-dependent body forces such as gravitational and centrifugal forces [87]. Recently, Thompson et al have reported the effect of material density on the margination and adhesion efficiency of particles to the vascular wall [25]. The targeting of 500-nm sLe A -coated polystyrene, silica, and titanium nanospheres (densities of 1.05, 2.0, and 3.9 g ml −1 , respectively) to inflamed endothelium from human blood flow in a PPFC, an in vitro model of human vasculature, was investigated.…”

Section: The Effect Of Particle Densitymentioning

confidence: 99%

“…Recently, particles with nonspherical shapes [21,22] and micrometer sizes [15,23,24] have been increasingly recognized as better carriers for targeting CVD. Particle density has also appeared as an important factor affecting particle margination to blood vessel walls [23,25].…”

Section: Introductionmentioning

confidence: 99%

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The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

Truong

Whittaker

et al. 2017

Expert Opinion on Drug Delivery

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Introduction: Vascular-targeted drug delivery is a promising approach for the treatment of atherosclerosis, due to the vast involvement of endothelium in the initiation and growth of plaque, a characteristic of atherosclerosis. One of the major challenges in carrier design for targeting cardiovascular diseases (CVD) is that carriers must be able to navigate the circulation system and efficiently marginate to the endothelium in order to interact with the target receptors. Areas covered: This review draws on studies that have focused on the role of particle size, shape, and density (along with flow hemodynamics and hemorheology) on the localization of the particles to activated endothelial cell surfaces and vascular walls under different flow conditions, especially those relevant to atherosclerosis. Expert opinion: Generally, the size, shape, and density of a particle affect its adhesion to vascular walls synergistically, and these three factors should be considered simultaneously when designing an optimal carrier for targeting CVD. Available preliminary data should encourage more studies to be conducted to investigate the use of nano-constructs, characterized by a sub-micrometer size, a non-spherical shape, and a high material density to maximize vascular wall margination and minimize capillary entrapment, as carriers for targeting CVD. ARTICLE HISTORY

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Section: The Effect Of Particle Densitysupporting

confidence: 67%

Section: The Effect Of Particle Densitymentioning

confidence: 99%

Section: The Effect Of Particle Densitymentioning

confidence: 99%

Section: The Effect Of Particle Densitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

Truong

Whittaker

et al. 2017

Expert Opinion on Drug Delivery

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A chemical engineering perspective of nanoparticle‐based targeted drug delivery: A unit process approach

Anselmo

Mitragotri

2016

AIChE Journal

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Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density

Tang

Peng

et al. 2016

Angewandte Chemie

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Identifying key factors that govern in vivo behaviors of nanomaterials is critical to future clinical translation of nanomedicines. Shadowed by size-, shape-and surface-chemistry effects, the impact of particle core density on clearance and tumor targeting of inorganic nanoparticles (NPs) remains largely unknown. By utilizing a class of ultrasmall metal NPs with the same size and surface chemistry but different densities as model, we found that both renal clearance and passive tumor targeting of the NPs are strongly correlated with their densities: with the decrease of particle density, renal-clearance efficiency exponentially increased in the early elimination phase but passive tumor targeting was linearly decreased. Through systematic investigation on their pharmacokinetics, biodistribution and kidney filtration, we found that lower density NPs more easily distribute in the body and have shorter retention in highly permeable organs such as kidneys than the higher ones. These density-dependent in vivo behaviors are likely due to the fact that high-density AuNPs marginated to the blood vessel walls more quickly than low-density NPs; as a result, they circulated slowly in the laminar blood flow than the low-density ones. These new findings highlight the importance of particle density in tailoring of in vivo behaviors of engineering NPs and might open up a new pathway for designing nanomedicines with desired functionalities together with other key factors.Unraveling key factors that are involved in nano-bio interactions in vivo is fundamental importance of translating nanomedicines into the clinics. [1] In the past decades, size, shape and surface chemistry of inorganic NPs have found to significantly affect their in vivo behaviors. [2] For example, Chan et al. found that gold nanoparticles (AuNPs) with different sizes show distinct tumor uptakes and penetration depths. [3] Among the AuNPs with sizes ranging from 20 to 100 nm, the small 20 nm AuNPs exhibited the lower accumulation but larger penetration depth in the tumor than others. Xia et al. investigated shape-effect on in vivo behaviors of gold nanostructures and found that nanospheres have longer blood circulation and higher tumor uptake over other shaped Au nanostructures. [4] Moreover, various surface chemistries have been widely used to manipulate in vivo behaviors of nanomedicines. [5] * jiezheng@utdallas.edu. On an even smaller size scale, however, whether density can still significantly affect in vivo behaviors of inorganic NPs with different compositions is not clear even though they exhibited distinct clearance efficiency and tumor targeting. [7] For instance, Choi et al. systematically investigated renal clearance of cysteine coated CdSe/ZnS quantum dots (QDs) and found that almost all the 4.36 nm QDs can be renally cleared within 24 h after intravenous injection. [8] Similar to these QDs, silica NPs also exhibited very high renal clearance efficiencies: about 70 percent of injected dose (%ID) of silica NPs was excreted in urine at 24 h post...

show abstract

Dense nanoparticles exhibit enhanced vascular wall targeting over neutrally buoyant nanoparticles in human blood flow

Cited by 30 publications

References 64 publications

The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

A chemical engineering perspective of nanoparticle‐based targeted drug delivery: A unit process approach

Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density

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