2020
DOI: 10.1101/2020.06.25.172452
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Dense time-course gene expression profiling of the Drosophila melanogaster innate immune response

Abstract: Immune responses need to be initiated rapidly, and maintained as needed, to prevent establishment and growth of infections. Still, immune genes differ in both initiation kinetics and shutdown dynamics. Here, we performed an RNA-seq time course on D. melanogaster with 20 time points post-LPS injection. A combination of methods, including spline fitting, cluster analysis, and Granger Causality inference, allowed detailed dissection of expression profiles and functional annotation of genes through guilt-by-associ… Show more

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References 128 publications
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