Densification Behavior and Mechanical Properties of Biomimetic Apatite Nanocrystals

Eskandari, A.; Aminzare, M.; Hassani, Hamid; Barounian, H.; Hesaraki, Saeed; Sadrnezhaad, S.K.

doi:10.2174/157341311797483646

Cited by 12 publications

(3 citation statements)

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“…It has the advantages of simplicity, reproducibility, low cost, and ease of producing (even in bulk quantities) of nanostructured materials [9,10]. The outstanding biological potentials of nanostructured biomaterials, which have not been observed in the conventional polycrystalline coarse grained materials, have been reported by previous studies [11][12][13].…”

Section: Introductionmentioning

confidence: 93%

Effect of Cu2+ ion on Biological Performance of Nanostructured Fluorapatite Doped with Copper

2017

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Abstract. Nanostructured copper-doped uorapatite (Cu x .Ca (10 x) .(PO 4 ) 6 .F 2 ) having crystallite sizes of 19, 29, and 34 nm at x = 0:9, 0.4, and 0.0, respectively, was synthesized by planetary ball milling of CaO, P2O5, CaF2, and CuO powders. Speci cations of the products were determined by Fourier-transform infrared spectroscopy, eld emission scanning electron microscopy, transmission electron microscopy, and X-ray di raction analyses. In-vitro studies and Mossman's Tetrazole Test (MTT) assays were also conducted by incubating Cu x .Ca (10 x) .(PO 4 ) 6 .F 2 powder into Kokubo's Simulated Body Fluid (SBF) and against BT-20 cell, respectively, to determine bioactivity and biocompatibility of the materials. Antibacterial e ects on Staphylococcus aureus were assessed by the disc di usion test method. Measurements showed that the rate of formation of uorapatite was lowered by Cu content. Besides, in-vitro experiments showed the same SBF interacted apatite precipitation for all samples. In contrast, MTT assays revealed di erent behavior for pure uorapatite and apatite with x = 0:9 Cu against BT-20 cell after 24 h of incubation. This highlights the increase of uorapatite cytotoxicity when Cu ion is present in the apatite structure. Copper-doped uorapatite was, however, desirably antibacterial. This stemmed from copper ions interactions with the bacterial metabolism which resulted in enzymes neutralization and copper-doped uorapatite antibacterial behavior.

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Section: Introductionmentioning

confidence: 93%

Effect of Cu2+ ion on Biological Performance of Nanostructured Fluorapatite Doped with Copper

2017

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“…For example, HA bioceramics can be pressurelessly sintered up to the theoretical density at 1000–1200 °C. Processing at even higher temperatures usually lead to exaggerated grain growth and decomposition because HA becomes unstable at temperatures exceeding ~1300 °C [6,131,132,133,134,135,136,281,282,283,284]. The decomposition temperature of HA bioceramics is a function of the partial pressure of water vapor.…”

Section: Bioceramics Of Calcium Orthophosphatesmentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

232

153

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Various types of grafts have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A bit later, such synthetic biomaterials were called bioceramics. In principle, bioceramics can be prepared from diverse materials but this review is limited to calcium orthophosphate-based formulations only, which possess the specific advantages due to the chemical similarity to mammalian bones and teeth. During the past 40 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the calcium orthophosphate-based implants remain biologically stable once incorporated into the skeletal structure or whether they were resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed and such formulations became an integrated part of the tissue engineering approach. Now calcium orthophosphate scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous and harbor different biomolecules and/or cells. Therefore, current biomedical applications of calcium orthophosphate bioceramics include bone augmentations, artificial bone grafts, maxillofacial reconstruction, spinal fusion, periodontal disease repairs and bone fillers after tumor surgery. Perspective future applications comprise drug delivery and tissue engineering purposes because calcium orthophosphates appear to be promising carriers of growth factors, bioactive peptides and various types of cells.

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“…Solid-state pressureless sintering is the simplest procedure. For example, HA bioceramics can be pressurelessly sintered up to the theoretical density at 1000-1200 • C. Processing at even higher temperatures usually lead to exaggerated grain growth and decomposition because HA becomes unstable at temperatures exceeding ~1300 • C [6,[113][114][115][116][117][279][280][281]. The decomposition temperature of HA bioceramics is a function of the partial pressure of water vapor.…”

Section: Sintering and Firingmentioning

confidence: 99%

Calcium Orthophosphate (CaPO4)-Based Bioceramics: Preparation, Properties, and Applications

Dorozhkin¹

2022

Coatings

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Various types of materials have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A short time later, such synthetic biomaterials were called bioceramics. Bioceramics can be prepared from diverse inorganic substances, but this review is limited to calcium orthophosphate (CaPO4)-based formulations only, due to its chemical similarity to mammalian bones and teeth. During the past 50 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the CaPO4-based implants would remain biologically stable once incorporated into the skeletal structure or whether they would be resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed, and such formulations became an integrated part of the tissue engineering approach. Now, CaPO4-based scaffolds are designed to induce bone formation and vascularization. These scaffolds are usually porous and harbor various biomolecules and/or cells. Therefore, current biomedical applications of CaPO4-based bioceramics include artificial bone grafts, bone augmentations, maxillofacial reconstruction, spinal fusion, and periodontal disease repairs, as well as bone fillers after tumor surgery. Prospective future applications comprise drug delivery and tissue engineering purposes because CaPO4 appear to be promising carriers of growth factors, bioactive peptides, and various types of cells.

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Densification Behavior and Mechanical Properties of Biomimetic Apatite Nanocrystals

Cited by 12 publications

References 0 publications

Effect of Cu2+ ion on Biological Performance of Nanostructured Fluorapatite Doped with Copper

Effect of Cu2+ ion on Biological Performance of Nanostructured Fluorapatite Doped with Copper

Calcium Orthophosphate-Based Bioceramics

Calcium Orthophosphate (CaPO4)-Based Bioceramics: Preparation, Properties, and Applications

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