Density and maturation of rodlet cells in brain tissue of fathead minnows (Pimephales promelas) exposed to trematode cercariae

Matisz, Chelsea E.; Goater, Cameron P.; Bray, D. F.

doi:10.1016/j.ijpara.2009.08.013

Cited by 41 publications

(43 citation statements)

References 22 publications

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“…Desmin is localized in all muscle types (striated muscle, cardiac muscle, and smooth muscle), whereas the microfilament protein SMA plays a role in the differentiation and structural support of smooth muscle cells and only found in smooth muscle cells [Matisz et al, 2010]. Telocytes express desmin in Soay ram seminal vesicles [Abd-Elhafeez et al, 2017].…”

Section: Discussionmentioning

confidence: 99%

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Abd‐Elhafeez

Soliman

2016

Cells Tissues Organs

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Telocytes are a special type of interstitial cells characterized by distinctive cellular extensions with alternating thin segments (podomers) and dilations (podoms). Telocytes establish contact with various cells and structures, but their role in the regulation of the function of many cell types is still obscure. The aim of the current study was to investigate the morphology, histochemistry, and immunohistochemistry of telocytes, and their distribution, organization, and morphometric measurements in different layers of the adult bovine uterine tube. Telocytes showed positive immunostaining for CD117, S-100 protein, vimentin, desmin, α-smooth muscle actin, tubulin, laminin, estrogen receptor-α, and progesterone receptor. They were organized in different types of sheaths: subepithelial, inner/outer perimuscular, and intramuscular sheaths. Telocytes were scattered in the lamina propria, in the muscular layer, and the serosa. According to their size, they were grouped into different types of telocytes: small, large, and giant telocytes. Small telocytes were the most common type and located in all layers; large telocytes were observed in the epithelium, lamina propria, and inner/outer perimuscular and intramuscular sheaths, and giant telocytes were found in the external layer of the outer perimuscular sheath. Telocytes were connected by thin and thick telopodes (fenestrated membranes). Fenestrated membranes enabled connections between telocytes along the entire muscular wall of the uterine tube. Telocytes established an extensive biological network of different types of cells and structures, including epithelial, muscular, and mast cells, blood vessels, glomus, and nerve fibers. We hypothesize that telocytes help to organize the functional coordination between different types of cells in the uterine tube.

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Section: Discussionmentioning

confidence: 99%

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Abd‐Elhafeez

Soliman

2016

Cells Tissues Organs

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“…Teleost fish possess rodlet cells, so named for the rod-shaped structures present within each cell, whose primary function appears to be to respond to tissue injury, especially in the cases of parasitic infection (Dezfuli et al, 2007;Matisz et al, 2010;Schmachtenberg, 2007). Brain-encysting metacercariae evoke a strong response by rodlet cells in freshwater minnows, where rodlet cells surround the offending worm and increase in density as more damage is incurred by developing metacercariae (Matisz et al, 2010).…”

Section: Immune Systemmentioning

confidence: 99%

“…Brain-encysting metacercariae evoke a strong response by rodlet cells in freshwater minnows, where rodlet cells surround the offending worm and increase in density as more damage is incurred by developing metacercariae (Matisz et al, 2010). Rodlet cells are not found in the brains of uninfected conspecifics (Dezfuli et al, 2007).…”

Section: Immune Systemmentioning

confidence: 99%

“…Rodlet cells are not found in the brains of uninfected conspecifics (Dezfuli et al, 2007). Rodlet cells are thought to be a part of a larger inflammatory response that includes increased vascularization and a proliferation of fibroblasts to the site of injury (Matisz et al, 2010). The latter is intriguing when considering that brain-encysting E. californiensis metacercariae express three types of fibroblast growth factors on the surface of their cysts (Shaw et al, 2009).…”

Section: Immune Systemmentioning

confidence: 99%

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Comparing mechanisms of host manipulation across host and parasite taxa

Lafferty

Shaw

2013

Journal of Experimental Biology

169

167

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SummaryParasites affect host behavior in several ways. They can alter activity, microhabitats or both. For trophically transmitted parasites (the focus of our study), decreased activity might impair the ability of hosts to respond to final-host predators, and increased activity and altered microhabitat choice might increase contact rates between hosts and final-host predators. In an analysis of trophically transmitted parasites, more parasite groups altered activity than altered microhabitat choice. Parasites that infected vertebrates were more likely to impair the hostʼs reaction to predators, whereas parasites that infected invertebrates were more likely to increase the hostʼs contact with predators. The site of infection might affect how parasites manipulate their hosts. For instance, parasites in the central nervous system seem particularly suited to manipulating host behavior. Manipulative parasites commonly occupy the body cavity, muscles and central nervous systems of their hosts. Acanthocephalans in the data set differed from other taxa in that they occurred exclusively in the body cavity of invertebrates. In addition, they were more likely to alter microhabitat choice than activity. Parasites in the body cavity (across parasite types) were more likely to be associated with increased host contact with predators. Parasites can manipulate the host through energetic drain, but most parasites use more sophisticated means. For instance, parasites target four physiological systems that shape behavior in both invertebrates and vertebrates: neural, endocrine, neuromodulatory and immunomodulatory. The interconnections between these systems make it difficult to isolate specific mechanisms of host behavioral manipulation.

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“…The most widely accepted reason is the lack of advanced immunological responses in these tissues, which helps the parasite to evade the host's chemical and cellular immune defences and also aids in the metacercariae remaining unencapsulated and free-moving (Bell and Hopkins 1956;Koornneef et al 1981;Barber and Crompton 1997;Dezfuli et al 2007;Sitjà-Bobadilla 2008). Free-moving metacercariae may, however, occasionally migrate to the eye blood capillaries where slight inflammation does occur and results in encapsulation and these structures may become lodged within the eye capillaries (Shariff et al 1980;Matisz et al 2010). Grobbelaar et al (2014) originally presented results on the prevalence and intensity of infection from all of the fish populations collected in the Okavango and Orange-Vaal River Systems and elaborated on ecological factors that could influence the life history of these diplostomids.…”

mentioning

confidence: 99%

Pathology of eyes and brain of fish infected with diplostomids, southern Africa

Grobbelaar

et al. 2015

African Zoology

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Density and maturation of rodlet cells in brain tissue of fathead minnows (Pimephales promelas) exposed to trematode cercariae

Cited by 41 publications

References 22 publications

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Comparing mechanisms of host manipulation across host and parasite taxa

Pathology of eyes and brain of fish infected with diplostomids, southern Africa

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