Density and ultrasonic velocity of undersaturated and supersaturated solutions of fluoranthene in trichloroethylene, and study of their metastable zone width

Marciniak, Bernard

doi:10.1016/s0022-0248(01)02088-7

Cited by 57 publications

(62 citation statements)

References 17 publications

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“…Its measure is the maximum undercooling expressed as the difference between saturation temperature and the temperature at which precipitation begins. 12 To determine the MSZW, the transparent saturated solution was heated to a temperature that was 208C higher than its equilibrium saturation temperature, T o . This overheated solution was then cooled down according to various temperature profiles of each run according to the L9 design (Fig.…”

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confidence: 99%

Study on the metastable zone width of ketoprofen

Lu¹,

Ching²

2006

Chirality

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With increasing awareness for the need of pure enantiomer drugs, strong emphasis has been focused on the research of chiral drug separation. Compared with other separation methods, crystallization is a simple and economical method, and the metastable zone width (MSZW) is a very important factor for the entire crystallization process. In this paper, the effects of the metastable zones of (R,S)- and (S)-ketoprofen and a 0.94 mole fraction of (S)-ketoprofen in order to enhance the MSZW were studied. Four main factors were studied, namely, temperature, cooling rate, stirring rate, and volume ratio of mixed solvent (water/ethanol). Through the L9 fractional experiment design, it was observed that all samples' MSZWs would increase with an increase in cooling rate and decrease with an increase in the ethanol volume ratio and temperature. The ethanol ratio may have the strongest effect on the process and can greatly enhance the metastable zone, and the other three factors influence the MSZW only slightly. In conclusion, the these four factors for enhancing MSZW have been optimized: water-to-ethanol volume ratio, 1:0.6; temperature, 20 degrees C; stirring rate, 700 rpm; and cooling rate, 12.0 degrees C/h. All of these results will be helpful for the following chiral separation of ketoprofen by crystallization.

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confidence: 99%

Study on the metastable zone width of ketoprofen

Lu¹,

Ching²

2006

Chirality

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“…In the case of industrial crystallizers as a general rule, the level of supersaturation is maintained at about half the metastable zone (Marciniak, 2002).…”

Section: Metastable Zone Widthmentioning

confidence: 99%

Real-Time Analysis to Evaluate Crystallization Processes

Silva¹,

Silva²,

Sena³

2012

Crystallization - Science and Technology

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“…The accurate determination of induction period measured for various supersaturation ratios at constant temperature depends on the sensitive detection of nucleus. Many measurement technique have been used to detect the first event of nucleation, such as naked eye [8,9], particle counter [10,11], turbidity meter [12][13][14], FT-IR spectrometer [15], ultrasound sensor [16] and electrical conductivity [17]. The interfacial tension has been calculated using the experimentally determined values of the induction period.…”

Section: Introductionmentioning

confidence: 99%