Density dependent mechanical properties and structures of a freeze dried biopharmaceutical excipient – Sucrose

Devi, Sharmila

doi:10.1016/j.ejpb.2014.06.017

Cited by 16 publications

(4 citation statements)

References 51 publications

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“…2, freeze-dried formulations with different PVP contents show alike regular closed-cell hexagonal structures with comparable cell dimensions and cell wall thicknesses. Similar hexagonal structures for the different freeze-dried excipients (pure mannitol, gelatin and maltodextrin) were reported previously by us [21] as well as by other researchers (for instance, mannitol, sucrose and trehalose structures are presented in [32,33]). Regardless of the PVP content, the internal structures of the FD cakes reflect the geometrical structure of the ice crystals forming during the freezing stage.…”

Section: Internal Structuressupporting

confidence: 86%

Application of Texture Analysis Technique in Formulation Development of Lyophilized Orally Disintegrating Tablets Containing Mannitol, Polyvinylpyrrolidone and Amino Acids

Hackl

Ermolina

2019

AAPS PharmSciTech

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Orally disintegrating tablets (ODTs) attract a great attention as this easy swallowing dosage form often improves the patient compliance. In the current work orally disintegrating tablets comprising mannitol, polyvinylpyrrolidone and an amino acid (alanine, glycine or serine) with various PVP-to-amino acid ratios were formulated. The combination of mannitol and an amino acid was aimed to use the advantages of mannitol, the matrix supporting and disintegration agent, and to reduce the total amount of sugar/polyol in tablets. Tablets were manufactured by freeze-drying and their properties (appearance, internal structure, disintegration, mechanical and texture properties, moisture uptake, shrinkage, thermal properties) were assessed. In the work great emphasis was placed on illustrating the applicability of the Texture Analysis of the freeze-dried cakes directly in vials in formulation development. The results show that appearance, the mechanical properties, disintegration and shrinkage of the freezedried ODTs depend significantly on the excipient composition with PVP playing the leading role. Partial mannitol replacement with an amino acid has a limited impact on the tablet properties. The presence of an amino acid also has no impact on the PVP-mannitol interaction. The mechanical and texture properties of freeze-dried ODTs depend non-linearly on the PVP content. The transition between the different types of textures occurs in a narrow interval of PVP concentrations regardless of the type of amino acid in a formulation. The non-linear effect of PVP on various tablet properties should be taken into account when designing ODT formulations as it can compromise the robustness of the manufacturing process.

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Section: Internal Structuressupporting

confidence: 86%

Application of Texture Analysis Technique in Formulation Development of Lyophilized Orally Disintegrating Tablets Containing Mannitol, Polyvinylpyrrolidone and Amino Acids

Hackl

Ermolina

2019

AAPS PharmSciTech

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“…It was also shown that the density of the films increases with size by more than 15%. 5 Since several physical properties of a material are density-dependent, 6,7,8 we expect that technologically important electronic and optical properties would exhibit significant variations with thickness. We test this hypothesis on films grown by ALD, which allows fabrication of amorphous oxides of excellent quality, with precise and conformal morphology 9,10,11,12 .…”

Section: Introductionmentioning

confidence: 99%

Thickness dependence of the physical properties of atomic-layer deposited Al2O3

Etinger-Geller

Zoubenko

Baskin

et al. 2019

Journal of Applied Physics

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Inspired by nature, we investigate the short-range order effect on the physical properties of amorphous materials. Amorphous Al2O3 thin films exhibit a higher proportion of their 4-coordinated Al sites close to the surface, causing variations in the average short-range order of the film. Below some thickness, the density of these films changes with size. In this work, we address the short-range order effect, through the thickness, on the electronic and optical properties of atomic layer deposited (ALD) Al2O3 thin films. Both the refractive index and the permittivity were found to vary with size. The refractive index increased with thickness, and for thick films (~50 nm) it was comparable to that of bulk amorphous Al2O3. The permittivity increased with thickness as well, but did not attain those of the bulk material. We discuss how these effects correlate with the density and short-range order. These results shed light on the size effects in thin amorphous oxides, and may guide the design of electronic and optical components and devices.

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“…However, when only surfactants are incorporated in the discs, the DPV-loaded discs have a higher density. This is a great advantage for sustained drug release, since the higher density of freeze-dried systems generally implies a smaller average pore size in the structure [44].…”

Section: Apparent Density Calculationmentioning

confidence: 99%

Mucoadhesive Vaginal Discs based on Cyclodextrin and Surfactants for the Controlled Release of Antiretroviral Drugs to Prevent the Sexual Transmission of HIV

et al. 2020

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The strategies for developing vaginal microbicides to protect women against human immunodeficiency virus (HIV) sexual transmission are constantly changing. Although the initial dosage forms required daily administration to offer effective protection, the trend then moved towards sustained-release dosage forms that require less frequency of administration in order to improve women’s compliance with the treatment. Nevertheless, another possible strategy is to design on-demand products that can be used in a coitally-dependent manner and only need to be administered immediately before intercourse to offer protection. Vaginal discs based on freeze-dried hydroxypropylmethyl cellulose gels have been developed for this purpose, containing two surfactants, i.e., sodium dodecyl sulphate and polysorbate 60, alone or in combination with 2-hydroxypropyl-β-cyclodextrin, to achieve a formulation capable of incorporating both hydrophilic and lipophilic drugs. Several studies have been carried out to evaluate how the inclusion of these substances modifies the structure of gels (viscosity and consistency studies) and the porosimetry of the freeze-dried discs (scanning electron microscopy micrographs, mechanical properties, swelling behaviour). The drug release and mucoadhesive properties of the discs have also been evaluated with a view to their clinical application. The systems combining sodium dodecyl sulphate and 2-hydroxypropyl-β-cyclodextrin were found to be adequate for the vaginal administration of both Tenofovir and Dapivirine and also offer excellent mucoadhesion to vaginal tissue; these discs could therefore be an interesting option for a coitally-dependent administration to protect women against HIV transmission.

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Density dependent mechanical properties and structures of a freeze dried biopharmaceutical excipient – Sucrose

Cited by 16 publications

References 51 publications

Application of Texture Analysis Technique in Formulation Development of Lyophilized Orally Disintegrating Tablets Containing Mannitol, Polyvinylpyrrolidone and Amino Acids

Application of Texture Analysis Technique in Formulation Development of Lyophilized Orally Disintegrating Tablets Containing Mannitol, Polyvinylpyrrolidone and Amino Acids

Thickness dependence of the physical properties of atomic-layer deposited Al2O3

Mucoadhesive Vaginal Discs based on Cyclodextrin and Surfactants for the Controlled Release of Antiretroviral Drugs to Prevent the Sexual Transmission of HIV

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