Dental Abnormalities in Pituitary Dwarfism: A Case Report and Review of the Literature

Ferrante, Franco; Blasi, S; Crippa, Rolando; Angiero, Francesca

doi:10.1155/2017/5849173

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Hence, we thought that pituitary dwarfism has increased mortality compared to the normal population in surgery. Franco et al demonstrated that pituitary dwarfism there may be various anomalies of the dental apparatus, from the morphological profile and in terms of development (7). Patients with dwarfism due to various reasons need to be more cautious during anesthesia, and for patients with pituitary dwarfism, most people have a proportionately smaller airway without anatomic abnormalities (3,8).…”

Section: Discussionmentioning

confidence: 99%

Prostate biopsy free system for laparoscopic radical prostatectomy in a pituitary dwarfism: a case report

et al. 2020

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Prostate biopsy is the gold standard for the diagnosis of prostate cancer. However, not all patients are suitable for prostate biopsy. For example, some patients have anal stenosis, some patients are too old to withstand the pain caused by puncture, patients who are unwilling to undergo prostate biopsy.We found that there was currently no literature report on a specific solution to this problem. This is the first report of a laparoscopic radical prostatectomy (LRP) in a pituitary dwarfism who didn't have a prostate biopsy before LRP due to anal stenosis. And this report added a new method to diagnose prostate cancer. We present a case of a 61-year-old pituitary dwarfism who had a prostate specific antigen (PSA) of 32.13 ng/mL by physical examination and didn't perform prostate biopsy due to anal stenosis. Preoperative prostate MRI suggests a low-signal mass on the left side of the prostate and 68 Ga PSMA-11 PET/CT demonstrated that Abnormally high PSMA and CHO uptake on the left side of the prostate. Therefore, combined with the patient's PSA, MRI and 68 Ga PSMA-11 PET/CT, our clinical diagnosis was prostate cancer. Surgery was difficult due to narrow pelvic space, but achievable through LRP. Histological analysis revealed multifocal prostate cancer, with negative surgical margins and no extraprostatic extension. Postoperative patient had no serious complications and was discharged. Based on this case, For the first time, we proposed to make full use of the results of clinical tests and imaging examinations for the diagnosis and treatment of diseases without prostate biopsy.

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Section: Discussionmentioning

confidence: 99%

Prostate biopsy free system for laparoscopic radical prostatectomy in a pituitary dwarfism: a case report

et al. 2020

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“…The mutant protein misfolds and exerts a dominant negative effect through disruption of the trafficking and stability of wild-type GH1 (19,20), resulting in pituitary dwarfism. Orofacial anomalies are common in growth hormone deficiencies and include underdevelopment of the maxilla and mandible, delays in tooth eruption, and tooth agenesis or malposition (21,22). FTSJ3 has not been previously described as having a role in canine body size, although genome-wide studies have associated the locus with various height-( 23) and weight-related phenotypes in other species, including humans (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Variants in FtsJ RNA 2′-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs

Abrams

Hawks

Evans

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Domesticated dogs show unparalleled diversity in body size across breeds, but within breeds variation is limited by selective breeding. Many heritable diseases of dogs are found among breeds of similar sizes, suggesting that as in humans, alleles governing growth have pleiotropic effects. Here, we conducted independent genome-wide association studies in the small Shetland Sheepdog breed and discovered a locus on chromosome 9 that is associated with a dental abnormality called maxillary canine-tooth mesioversion (MCM) (P = 1.53 × 10−7) as well as two body size traits: height (P = 1.67 × 10−5) and weight (P = 1.16 × 10−7). Using whole-genome resequencing data, we identified variants in two proximal genes: FTSJ3, encoding an RNA methyltransferase, and GH1, encoding growth hormone. A substitution in FTSJ3 and a splice donor insertion in GH1 are strongly associated with MCM and reduced body size in Shetland Sheepdogs. We demonstrated in vitro that the GH1 variant leads to exon 3 skipping, predicting a mutant protein known to cause human pituitary dwarfism. Statistical modeling, however, indicates that the FTSJ3 variant is the stronger predictor of MCM and that each derived allele reduces body size by about 1 inch and 5 pounds. In a survey of 224 breeds, both FTSJ3 and GH1 variants are frequent among very small “toy” breeds and absent from larger breeds. Our findings indicate that a chromosome 9 locus harboring tightly linked variants in FTSJ3 and GH1 reduces growth in the Shetland Sheepdog and toy breed dogs and confers risk for MCM through vertical pleiotropy.

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“…The possibly causes of dwarfism are the insufficient of growth hormone and genetic complication. Persons with pituitary dwarfism caused by deficient growth hormone and persons with achondroplasia caused by gene mutation that induce abnormalities dental formation such as abnormal tooth size and shape, crowded and impaction teeth with high risk of dental carries and periodontitis (Ferrante, Blasi, Crippa, & Angiero, 2017).…”

Section: The Persons With Physical Disabilitiesmentioning

confidence: 99%

Effectiveness?of?a?personally-tailored?oral?care?program?on?improving?periodontal?status?among?Thai?persons?with?physical?disabilities?in?Pathum Thani?province,?Thailand

Sermsuti-anuwat

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The purpose of this study was to develop and evaluate the Personally-Tailored Oral Care Program on improving periodontal status among Thai persons with physical disabilities. This quasi-experimental study was conducted at Independent Living Center, a community club for persons with disabilities in Pathum Thani province, Thailand from February to May 2018. Total of 80 members who registered in Ladlumkaeo district (control) and Thanyaburi district (intervention), Pathum Thani Province were included (each group comprising 40 participants). Data were analyzed by using Chi-square test, t-test and repeated measures analysis of variance. The results, there were strongly significant difference in bleeding on probing (BOP), plaque index (PI) and oral health behavior knowledge mean score (p<0.001) and there was a significant difference in oral health literacy (p =?0.027) between the intervention and control group at the 12-week follow-up. Substantially significant differences in BOP, PI, OHB and OHL mean score were found within the intervention group after they received the Personally-Tailored Oral Care Program (p< 0.001). The Personally-Tailored Oral Care Program was effective for improving periodontal condition and generated oral health behavior knowledge and oral health literacy among Thai persons with physical disabilities.?

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Dental Abnormalities in Pituitary Dwarfism: A Case Report and Review of the Literature

Cited by 4 publications

References 12 publications

Prostate biopsy free system for laparoscopic radical prostatectomy in a pituitary dwarfism: a case report

Prostate biopsy free system for laparoscopic radical prostatectomy in a pituitary dwarfism: a case report

Variants in FtsJ RNA 2′-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs

Effectiveness?of?a?personally-tailored?oral?care?program?on?improving?periodontal?status?among?Thai?persons?with?physical?disabilities?in?Pathum Thani?province,?Thailand

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