Estimating the chronological age of humans is a prevalent need in forensic practice. Comparing the accuracy of different age identification methods helps provide the most reliable method for a specific population. This study aimed to compare the accuracy of age assessments using skeletal maturation and dental mineralization in a sample of Egyptians and to assess if combining both methods yields more precise age prediction. A cross-sectional study included 176 Egyptian children and adolescents aged between 8 and 16 who underwent orthopantomograms and hand-wrist radiographs. All radiographs were scored independently for skeletal maturation using the Fishman method and dental development using the Nolla method. While Fishman and Nolla methods were valid and reliable age predictors with variable sex and age group accuracy in Egyptians, the Nolla method showed superior performance. The Nolla method slightly underestimated the chronological age, while the Fishman method slightly over-estimated it, showing median differences of -0.21 and 0.17, respectively. Correlating the estimated age using the Fishman and Nolla methods and the chronological age showed intraclass correlation coefficients of (0.854 and 0.660) and (0.973 and 0.977) for females and males, respectively (P < 0.001). The model adopting the Nolla score exhibited the highest R² (0.973 and 0.968) and the lowest Akaike information criteria (96 and 106) for females and males, respectively, which is comparable to the model adopting both Nolla scores and skeletal maturation indicators. Therefore, we recommend adopting the model incorporating only the Nolla scores for age estimation without the need for further hand and wrist radiography.