Objective: We aimed to investigate whether the Prognos®
device might be a useful tool in the diagnosis of disorders
suspected to be due to dental amalgam fillings. Participants
and Methods: A diagnostic case-control study was performed
in 27 patients who complained about health problems
attributed to amalgam (cases), 27 healthy volunteers
with amalgam fillings (controls I), and 27 healthy amalgamfree
volunteers (controls II). All participants were tested before
and after application of 300 mg DMPS (2.3-dimercapto-
1-propanesulfonic acid) with Prognos®, a diagnostic device
for the energetic measurement of Traditional Chinese Medicine
meridians. In addition, mercury was measured in
blood, urine, and saliva, and a lymphocyte transformation
test (LTT) was performed. Results: Diagnoses derived from
the first and second Prognos® testing did not agree above
chance (Cohen’s Kappa = -0.11, 95% confidence interval
-0.33 to 0.10; p = 0.30). Agreement for secondary outcome
measures was poor, too. Prognos® measurements did not
differ between cases and controls. Correlations with measurements
in urine, blood and saliva were low. Conclusion:
In this study Prognos® could not be shown to be a useful
tool in the diagnosis of disorders suspected to be due to
dental amalgam fillings.