The current chapter, entitled “Indirect restorative polymeric dental materials,” is dedicated to one class of dental materials with wide indications in dental medicine. The chapter is an overview of polymeric resin composites dedicated to indirect restauration currently used and latest avail resin composite and polymers in dentistry. This chapter includes chemical composition, indications, light-curing mechanism and physical and mechanical properties of indirect conventional and new polymeric materials. Important aspects about resin composites are related to clinical and physical properties such as light-curing, aesthetics, wear rates and biocompatibility. The accuracy and longevity of indirect composite restorations depend on choosing the right material according to clinical requirements, material’s properties, and behaviour in the oral cavity and clinical indications. The chemical composition of resin composite, curing mechanism and advantages of these materials are presented in Introduction. The second section is dedicated to structure and composition of indirect polymers, indirect resin composites, first and second generation of indirect resin composites and their indications. Section 3 describes the structure and composition of high-performance hybrid polymers, hybrid ceramic and high-performance polymers, and poly ether ketone ketone dedicated to different processing technologies.