Dental assessment prior to stem cell transplant: treatment need and barriers to care

Durey, Kathryn; Patterson, Helen; Gordon, Kathryn H.

doi:10.1038/sj.bdj.2009.304

Cited by 26 publications

(34 citation statements)

References 19 publications

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“…As alterações radiográficas mais frequentes são microdontia generalizada, ausência de dentes por extrações e agenesias, transposições e supranumerários (ACIKGOZ et al, 2005;DE ARAUJO et al, 2007;TEKCICEK et al, 2007;DE ARAUJO et al, 2011;SHETTY et al, 2011 (STOOPLER et al, 2007;ISLAM et al, 2011). Na literatura investigada, as alterações estomatológicas mais frequentes nos pacientes em preparo para TCTH foram gengivite, acúmulo de biofilme, cálculo dentário, periodontite com bolsas profundas e perda significativa de osso alveolar, alto índice de cárie, redução de fluxo salivar, restaurações com infiltrações necessitando de retratamento, lesões periapicais, raízes residuais, dentes parcialmente irrompidos, mucosite, dor relacionada à articulação têmporo-mandibular, infecções oportunistas por fungos e vírus, infiltrado leucêmico gengival, petéquias, equimoses, língua saburrosa, úlceras traumáticas infectadas, erosão dental, hiperplasia ou hipertrofia gengival, alterações oclusais e na formação dos dentes após quimioterapia na infância (LUCAS et al, 1998;GRABER et al, 2001;MELKOS et al, 2003;VAUGHAN et al, 2005b;YAMAGATA et al, 2006;BRENNAN et al, 2008;DA SILVA SANTOS et al, 2008;DUREY et al, 2009;BOER et al, 2010;HONG et al, 2010;LAAKSONEN et al, 2011;PALMASON et al, 2011;GURGAN et al, 2012;HERNANDEZ-FERNANDEZ et al, 2012). A variedade de manifestações em diversos graus de intensidade é resultado do tempo variado entre o adoecimento e o momento do diagnóstico.…”

Section: Doenças Onco-hematológicasunclassified

“…BRENNAN et al, 2008;ELAD et al, 2008;DUREY et al, 2009;HAMADANI et al, 2010;DA SILVA SANTOS et al, 2011;YAMAGATA et al, 2011). (BRENNAN et al, 2008).…”

Section: O Paciente Em Preparo Para Tcthunclassified

“…( YAMAGATA et al, 2006;BRENNAN et al, 2008;GURGAN et al, 2012 , 2006;BRENNAN et al, 2008;DUREY et al, 2009;TOMBLYN et al, 2009;YAMAGATA et al, 2011;GURGAN et al, 2012 …”

Section: O Paciente Em Preparo Para Tcthunclassified

“…O preparo odontológico consiste orientação de higiene bucal e eliminação de possíveis focos de infecção e trauma pelo menos 10 dias antes do início da quimioterapia (LUCAS et al, 1998;GRABER et al, 2001;YAMAGATA et al, 2006;BRENNAN et al, 2008;DUREY et al, 2009;TOMBLYN et al, 2009;YAMAGATA et al, 2011;GURGAN et al, 2012).…”

Section: Rccunclassified

“…O uso do G-CSF reduz a incidência e a gravidade da neutropenia e neutropenia febril. (PARISI e GLICK, 2003;VAUGHAN et al, 2005b;KLOKKEVOLD e MEALEY, 2006;DUREY et al, 2009;KUMAR et al, 2010;SAUSVILLE e LONGO, 2010;YAMAGATA et al, 2011;GURGAN et al, 2012; …”

Section: Introdução 17unclassified

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Alterações estomatológicas de pacientes em preparo para transplante de células-tronco hematopoiéticas

Araújo¹

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disponibilidade, por abrir meus olhos para uma nova e dinâmica Odontologia, me levando a questionar e aprender a desaprender conceitos e protocolos. Agradeço as oportunidades concedidas, as ocasiões em que trabalhamos juntos, os exemplos de dedicação familiar e profissional e o esmero no cuidado com os pacientes.Um verdadeiro educador, que transmite muito mais que informação científica. (61%) men and 39 (39%) women with a median age of 39 years. The most frequent underlying diseases were acute lymphoblastic leukemia (20%) and acute myeloid leukemia (19%). It was found that 45% of patients had some stomatological alterations. The most prevalent were tongue coating, petechiae, bruising and dry lips. AGRADECIMENTOSPeriodontal disease was found in 62% of patients. The most common manifestations were gingival bleeding among young patients and the more severe forms of periodontitis occurred after 35 years. The caries activity was high (DMFT=14.04), only 09 patients were caries free and 14% of patients had indication for extraction.The overall mean of OHIP-14 was very low (4.62), however there was correlation with the presence of severely compromised teeth due to caries and periodontal disease (p<0.05), indicating a significant impact on quality of life. The most impacting factors were caries activity (p<0.05), restorations with caries (p<0.05) and edentulism (p<0.05). In severe cases with indication for extraction, the impact was significant in psychological distress (p<0.05), psychological incapacity (p<0.01) and deficiency (p<0.01), the greatest degree of impairment of quality of life. We conclude that patients referred for HSCT have several stomatological alterations. Only the cases of aplastic anemia have oral manifestations of primary disease. However, the frequency of gingivitis, periodontitis, and caries activity were high, revealing shortage in dental support during the patient preparation in their hometowns. The impact of oral health problems on quality of life is weak, but in severe cases there is psychological impairment.

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Section: Doenças Onco-hematológicasunclassified

“…BRENNAN et al, 2008;ELAD et al, 2008;DUREY et al, 2009;HAMADANI et al, 2010;DA SILVA SANTOS et al, 2011;YAMAGATA et al, 2011). (BRENNAN et al, 2008).…”

Section: O Paciente Em Preparo Para Tcthunclassified

“…( YAMAGATA et al, 2006;BRENNAN et al, 2008;GURGAN et al, 2012 , 2006;BRENNAN et al, 2008;DUREY et al, 2009;TOMBLYN et al, 2009;YAMAGATA et al, 2011;GURGAN et al, 2012 …”

Section: O Paciente Em Preparo Para Tcthunclassified

Section: Rccunclassified

Section: Introdução 17unclassified

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Alterações estomatológicas de pacientes em preparo para transplante de células-tronco hematopoiéticas

Araújo¹

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Oral health of adult patients undergoing hematopoietic cell transplantation. Pre-transplant assessment and care

et al. 2017

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Hematopoietic cell transplantation (HCT) is now one of the frequent procedures used for treatment of malignant and non-malignant blood diseases, autoimmune disorders, and certain solid tumors. Despite improvements of therapeutic protocols, HCT still carries a high risk of non-relapse mortality due to early and late complications. Side effects of the therapy regimen frequently occur in the oral cavity and often significantly decrease the patients’ quality of life. The complications may result from or may be exacerbated by improper oral preparation of the patient before transplantation. Therefore, it is mandatory that all patients referred to HCT undergo thorough dental examination and receive appropriate treatment before the procedure. It is also very important to develop an individual post-transplantation oral care protocol with special concerns to oral hygiene before implementation of the conditioning. This paper presents a review of dental management methods intended for patients before HCT proposed in literature as well as recommendations based on the experience of the Department of Comprehensive Dental Care and the Department of Conservative Dentistry of Warsaw Medical University and the Warsaw Institute of Hematology and Blood Transfusion. The article pays special attention to the problem of potential foci of infection and bleeding. It also presents protocol of oral hygiene in post-transplantation period, used by patients of Warsaw Medical University and Institute of Hematology and Blood Transfusion.

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Oral complaints and dental care of haematopoietic stem cell transplant patients: a qualitative survey of patients and their dentists

Braber

Potting

Bronkhorst

et al. 2014

Support Care Cancer

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Dental assessment prior to stem cell transplant: treatment need and barriers to care

Cited by 26 publications

References 19 publications

Alterações estomatológicas de pacientes em preparo para transplante de células-tronco hematopoiéticas

Alterações estomatológicas de pacientes em preparo para transplante de células-tronco hematopoiéticas

Oral health of adult patients undergoing hematopoietic cell transplantation. Pre-transplant assessment and care

Oral complaints and dental care of haematopoietic stem cell transplant patients: a qualitative survey of patients and their dentists

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