Dental caries and developmental defects of enamel in individuals with chronic kidney disease: Systematic review and meta‐analysis

Limeira, Francisco Ivison Rodrigues; Yamauti, Mónica; Moreira, Allyson Nogueira; Galdino, Tuélita Marques; Magalhães, Cláudia Silami de; Abreu, Lucas Guimarães

doi:10.1111/odi.12993

Cited by 18 publications

(15 citation statements)

References 58 publications

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“…In a systematic review and meta-analysis by Limeira et al, caries prevalence in adults with CKD and in healthy controls was compared; these authors reported lower caries scores in CKD patients [32]. Similar findings of lower prevalence of caries were reported for children and adolescents with CKD in a systematic review by Andrade et al [33].…”

Section: Cariesmentioning

confidence: 76%

How oral infections can influence chronic kidney disease – a review of the literature

Pontes¹,

Chikte²

2020

AJN

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A healthy mouth is necessary for optimal health and quality of life. However, oral health is often compromised in adults with chronic kidney disease (CKD). The aim of this review was to present the scientific foundations behind the connection between oral diseases and chronic kidney disease (CKD) in adults, discuss common oral conditions and their systemic effects, investigate biological pathways through which oral infections affect the body and provide guidelines for physicians/nephrologists. Prevalence of oral disease is increased in CKD, including periodontal disease, oral mucosal lesions, edentulousness, xerostomia, gingival overgrowth in immunosuppressed patients and potentially caries. There is moderate to strong evidence to support a negative impact of oral infections in CKD, particularly periodontal disease, with systemic inflammation, bacteraemia of oral origin, endothelial function and gut dysbiosis being potential pathways for this interaction. Poor oral health can be a hidden source of infection and has been associated with increased mortality in CKD patients. Elimination of potential foci for oral infections is crucial before renal transplantation. Frequent dental monitoring is crucial for these patients and should be part of a multidisciplinary approach to manage CKD, with special attention to end-stage kidney disease.

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Section: Cariesmentioning

confidence: 76%

How oral infections can influence chronic kidney disease – a review of the literature

Pontes¹,

Chikte²

2020

AJN

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“…Without appropriate treatment, children with cystinosis can develop kidney failure. The pathophysiological alterations associated with kidney failure and its treatment can affect the development and the mineralization of teeth, such as enamel hypoplasia and has been associated with the production of poorly formed enamel as a result of ameloblast disruption …”

Section: Introductionmentioning

confidence: 99%

“…The pathophysiological alterations associated with kidney failure and its treatment can affect the development and the mineralization of teeth, such as enamel hypoplasia and has been associated with the production of poorly formed enamel as a result of ameloblast disruption. 17 This paper describes oral alterations in two renal transplant patients with NC and highlighting the rehabilitation dental treatment used in one of them.…”

Section: Introductionmentioning

confidence: 99%

Oral alterations in patients with cystinosis

Tuma

Ordóñez-Aguilera

Rodriguez

et al. 2019

Special Care in Dentistry

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Cystinosis is a rare autosomal recessive lysosomal storage disorder, which leads to abnormal accumulation of cysteine in various organs, including progressive dysfunction of kidneys. The most severe and frequent form, affecting ∼95% of patients, is termed infantile nephropathic cystinosis (NC) (OMIM 219800). We have reported oral findings in two patients with NC and described esthetic and functional rehabilitation in one of them. The first case describes a 16‐year‐old male patient, who was diagnosed with NC when he was 1‐year‐old. The patient exhibited generalized enamel hypoplasia, grade 1 drug‐induced gingival overgrowth, caries lesion in molar tooth and supernumerary tooth (ie, distomolar). The second case describes a 14‐year‐old male patient diagnosed with NC at 3 years old. Clinical examination revealed generalized enamel hypoplasia and grade 1 drug‐induced gingival overgrowth. Radiographic examination showed supernumerary tooth (mesiodens). The treatment included gingivoplasty and restoration with direct composite resin. The severity of hypoplasia highlights the importance of a dental rehabilitation treatment, as proposed here. Direct restoration with composite resin allowed harmony, function, and esthetics to be restored, in addition to being a rapid and low‐cost technique.

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“…Cinco estudos mostraram que indivíduos com IRC tinham uma prevalência significativamente maior de defeitos de esmalte do que indivíduos saudáveis. O autor concluiu que indivíduos com IRC apresentam menores pontuações de lesão de cárie dentária e maior prevalência de defeitos de esmalte em comparação com indivíduos saudáveis (Limeira et al, 2018). Costa et al (2017), as crianças que tiveram sucesso no TR mostram mudanças na composição salivar para a normalidade, portanto pode ter um risco maior de desenvolver cáries dentárias.…”

Section: Doença Cárieunclassified

Alterações bucais em crianças e adolescentes transplantados renais

Tuma¹

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Tuma MM. Oral Changes in renal transplanted children and adolescents [dissertation]. São Paulo: Faculdade de Odontologia da USP; 2018. Versão Original. Renal transplanted children and adolescents need dental care on a routine basis as there are oral changes related to some underlying diseases as well as to the transplantation itself and immunosuppressive therapy. The objective of the present study is to know and identify the oral health of these patients in order to seek possible relationships with the underlying disease which led to kidney transplantation, transplantation time and adopted immunosuppressive approach. Anamnesis and clinical examination were conducted to evaluate the presence of caries lesions (DMFT/dmf-t indexes), enamel defects (modified DDE index), periodontal condition (modified IPC index) and presence of soft tissue changes. This is an observational, cross-sectional study performed between August 2017 and June 2018 in which renal transplant recipients aged 2-17 years old were followed up at the São Paulo Hospital of Kidney in Brazil. A total of 120 participants were included, with 63 (52.5%) being males with mean age 12.78±3.9 years old. Unknown causes of renal failure involved the majority of the cases, that is, 28 (23.3%), whereas posterior urethral valve (PUV) involved 14 cases (11.7%). Gingival bleeding was observed in 115 (95.8%) participants, dental calculus in 69 (57.5%), caries experience in 51 (42.5%), enamel defects in 49 (40.8%), drug-related gingival hyperplasia (DRGH) in 20 (16.7%), xerostomia in 15 (12.5%) and soft tissue lesions in 5 (4.2%), such as ulcers, geographic tongue and oral wart lesions. The majority of the participants (55%) needed some dental treatment. The use of amlodipine and anticonvulsants has been associated with the presence of DRGH, whereas the immunosuppressant everolimus associated with ulceration (p < 0.05). We have concluded that periodontal disease and caries lesions were the most frequent oral conditions, leading to significant need for dental treatment in the population studied. Most of the oral changes observed were related to the underlying disease (i.e. renal failure), especially enamel defects. Oral opportunistic infections were rarely observed and drug treatment was associated with the presence of ulceration (use of everolimus) and DRGH (use of amlodipine and anticonvulsivants).

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Dental caries and developmental defects of enamel in individuals with chronic kidney disease: Systematic review and meta‐analysis

Cited by 18 publications

References 58 publications

How oral infections can influence chronic kidney disease – a review of the literature

How oral infections can influence chronic kidney disease – a review of the literature

Oral alterations in patients with cystinosis

Alterações bucais em crianças e adolescentes transplantados renais

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