Dental Caries and Head and Neck Cancers

Tezal, Miné; Scannapieco, Frank A.; Wactawski‐Wende, Jean; Meurman, Jukka H.; Marshall, James R.; Rojas, Isolde G.; Stoler, Daniel L.; Genco, Robert J.

doi:10.1001/jamaoto.2013.4569

Cited by 37 publications

(21 citation statements)

References 32 publications

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“…In addition, recent findings emphasize on the relationship between dental caries and some cancers e.g. head and neck and gastric cancers as well (11)(12)(13)(14). However, as recommended by American Dental Association (ADA), regular habits of tooth brushing (≥twice a day) and flossing (≥once a day) can effectively prevent these conditions (15).…”

mentioning

confidence: 99%

Oral hygiene status in a general population of Iran, 2011: a key lifestyle marker in relation to common risk factors of non-communicable diseases

Asgari

Majidi

Koohpayehzadeh

et al. 2015

Int J Health Policy Manag

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Background: To estimate Oral Hygiene (OH) status in the Iranian population in 2011, and to determine the influence of socio-economic characteristics on OH, and its interrelation with common risk factors of Non-Communicable Diseases (NCDs). Methods: Data including a total of 12,105 individuals aged 6-70 years were obtained from the sixth round of the surveys of NCDs risk factors in Iran. OH was recorded through a structured questionnaire measuring daily frequencies of tooth brushing and dental flossing. Descriptive analyses were performed on demographic characteristics in the complex sample survey setting. We also employed weighted binary logistic regression to compute Odds Ratio (OR) as a measure of association between the response and explanatory factors. Furthermore, to construct an asset index, we utilized Principal Component Analysis (PCA). Results:The percentage with minimum recommended daily OH practices was 3.7% among men and 7.7% among women (OR= 2.3; P< 0.001). Urban citizens were more likely to have their teeth cleaned compared to rural people (OR= 2.8; P< 0.001). For both genders, a relatively better condition was observed in the 25-34 age group (male: 5.6%; female: 10.3%). In addition, OH status improved significantly by increase in both level of education (P< 0.001) and economic status (P< 0.001). There were also apparent associations between self-care practices and specific behavioral risk factors, though the correlation with dietary habits and tobacco use could be largely explained by socio-economic factors. Conclusion: OH situation in Iran calls for urgent need to assign proper interventions and strategies toward raising public awareness and reducing disparities in access to health facilities.

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confidence: 99%

Oral hygiene status in a general population of Iran, 2011: a key lifestyle marker in relation to common risk factors of non-communicable diseases

Asgari

Majidi

Koohpayehzadeh

et al. 2015

Int J Health Policy Manag

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“…34,42,43 Our study showed that both CD8+ and FoxP3+ cell densities increase in AC as compared to NL, but a larger increase in stromal FoxP3+ cell density relative to CD8+ cells is responsible for the observed reduction in the CD8+/FoxP3+ ratio. 34,42,43 Our study showed that both CD8+ and FoxP3+ cell densities increase in AC as compared to NL, but a larger increase in stromal FoxP3+ cell density relative to CD8+ cells is responsible for the observed reduction in the CD8+/FoxP3+ ratio.…”

Section: Discussionmentioning

confidence: 55%

“…The importance of the local immune microenvironment for oral and skin carcinogenesis has been widely accepted; however, evidence for the combined roles of specific immune cell subsets is lacking at preneoplastic stages. 34,42,43 Our study showed that both CD8+ and FoxP3+ cell densities increase in AC as compared to NL, but a larger increase in stromal FoxP3+ cell density relative to CD8+ cells is responsible for the observed reduction in the CD8+/FoxP3+ ratio. Furthermore, our results suggest that FoxP3+ cell density is associated with AC independent of sun exposure, smoking status, age at diagnosis, and gender, and provides for the first time an estimate of effect size for this association.…”

Section: Discussionmentioning

confidence: 55%

CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis

et al. 2016

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“…This could be attributed to the normal commensals of the oral cavity. The mechanisms which could protect the host from the cancer include antitumorigenic or antimutagenic compounds produced by the bacteria, regulation of cytokine production, production of antimicrobial substances, clearance, inhibition of growth and downregulation of fimbrial expression of Gram-negative bacteria, production of surfactants, and stabilization of low pH [15,16].…”

Section: Discussionmentioning

confidence: 99%

Effect of Tobacco Extract on Streptococcus Mutans: Possible Role in Modulating Carcinogenesis

Arun

Natarajan

Suman

et al. 2018

Asian J Pharm Clin Res

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Objective: Tobacco use in the smoking or smokeless form is the most common form of substance abuse recorded in the world. Not only does tobacco influence carcinogenesis but also modifies the oral microflora. The aim of our study was to assess the growth pattern of Streptococcus mutans under the influence of cigarette extract.Methods: Pure stock culture of S. mutans was grown in brain heart infusion broth mixed with three concentrations of aqueous cigarette extract. Quantification of the S. mutans colonies was performed in Mitis Salivarius Agar subculture. Biofilm assessment was also performed to find the adherent property of microorganisms.Statistical Analysis used: One-way ANOVA was used to compare the effect of cigarette extract on growth and biofilm formation of S. mutans. Results: There was increase in the colony counts with increasing concentration of cigarette extract (p<0.001). There was an observable trend noted in the biofilm assay.Conclusion: The colony growth is positively influenced by the cigarette additives (sugars and sweeteners), carbon dioxide environment, and biofilm modification. The altered flora with higher S. mutans may be linked with the higher salivary acetaldehyde production which promotes carcinogenesis. The flora may be protective by production of antitumorigenic or antimutagenic compounds. The balance between the carcinogenic and anticarcinogenic signals produced by tobacco and microflora influences the outcome of the disease.

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Dental Caries and Head and Neck Cancers

Abstract: There is an inverse association between HNSCC and dental caries. This study provides insights for future studies to assess potential beneficial effects of lactic acid bacteria and the associated immune response on HNSCC.

Cited by 37 publications

References 32 publications

Oral hygiene status in a general population of Iran, 2011: a key lifestyle marker in relation to common risk factors of non-communicable diseases

Oral hygiene status in a general population of Iran, 2011: a key lifestyle marker in relation to common risk factors of non-communicable diseases

CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis

Effect of Tobacco Extract on Streptococcus Mutans: Possible Role in Modulating Carcinogenesis

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